Engineering Saccharomyces cerevisiae for co-utilization of D-galacturonic acid and D-glucose from citrus peel waste

Pectin-rich biomasses, such as citrus peel and sugar beet pulp, hold promise as inexpensive feedstocks for microbial fermentations as enzymatic hydrolysis of their component polysaccharides can be accomplished inexpensively to yield high concentrations of fermentable sugars and D-galacturonic acid (...

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Published inNature communications Vol. 9; no. 1; pp. 5059 - 10
Main Authors Protzko, Ryan J, Latimer, Luke N, Martinho, Ze, de Reus, Elise, Seibert, Tanja, Benz, J Philipp, Dueber, John E
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 29.11.2018
Nature Publishing Group UK
Nature Portfolio
Subjects
Aspergillus niger - metabolism
Baking yeast
BASIC BIOLOGICAL SCIENCES
Citrus - metabolism
D-Galacturonic acid
Engineering
Fermentation - genetics
Fermentation - physiology
Glucose
Glucose - metabolism
Hexose
Hexuronic Acids - metabolism
Hydrolysates
Microorganisms
Oranges
Organic chemistry
Pectin
Polysaccharides
Pulp
Saccharides
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Sugar
Utilization
Yeast
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Abstract Pectin-rich biomasses, such as citrus peel and sugar beet pulp, hold promise as inexpensive feedstocks for microbial fermentations as enzymatic hydrolysis of their component polysaccharides can be accomplished inexpensively to yield high concentrations of fermentable sugars and D-galacturonic acid (D-galUA). In this study, we tackle a number of challenges associated with engineering a microbial strain to convert pectin-rich hydrolysates into commodity and specialty chemicals. First, we engineer D-galUA utilization into yeast, Saccharomyces cerevisiae. Second, we identify that the mechanism of D-galUA uptake into yeast is mediated by hexose transporters and that consumption of D-galUA is inhibited by D-glucose. Third, we enable co-utilization of D-galUA and D-glucose by identifying and expressing a heterologous transporter, GatA, from Aspergillus niger. Last, we demonstrate the use of this transporter for production of the platform chemical, meso-galactaric acid, directly from industrial Navel orange peel waste.
AbstractList Abstract Pectin-rich biomasses, such as citrus peel and sugar beet pulp, hold promise as inexpensive feedstocks for microbial fermentations as enzymatic hydrolysis of their component polysaccharides can be accomplished inexpensively to yield high concentrations of fermentable sugars and d -galacturonic acid ( d -galUA). In this study, we tackle a number of challenges associated with engineering a microbial strain to convert pectin-rich hydrolysates into commodity and specialty chemicals. First, we engineer d -galUA utilization into yeast, Saccharomyces cerevisiae . Second, we identify that the mechanism of d -galUA uptake into yeast is mediated by hexose transporters and that consumption of d -galUA is inhibited by d -glucose. Third, we enable co-utilization of d -galUA and d -glucose by identifying and expressing a heterologous transporter, GatA, from Aspergillus niger . Last, we demonstrate the use of this transporter for production of the platform chemical, meso -galactaric acid, directly from industrial Navel orange peel waste.
Pectin-rich agricultural byproducts are ideal feedstocks for biobased chemicals production. Here, the authors engineer the yeast, S. cerevisiae, in several steps to co-utilize d-galacturonic acid and d-glucose and demonstrate the potential of producing meso-galactaric acid from industrial orange peel.
Pectin-rich biomasses, such as citrus peel and sugar beet pulp, hold promise as inexpensive feedstocks for microbial fermentations as enzymatic hydrolysis of their component polysaccharides can be accomplished inexpensively to yield high concentrations of fermentable sugars and d-galacturonic acid (d-galUA). In this study, we tackle a number of challenges associated with engineering a microbial strain to convert pectin-rich hydrolysates into commodity and specialty chemicals. First, we engineer d-galUA utilization into yeast, Saccharomyces cerevisiae. Second, we identify that the mechanism of d-galUA uptake into yeast is mediated by hexose transporters and that consumption of d-galUA is inhibited by d-glucose. Third, we enable co-utilization of d-galUA and d-glucose by identifying and expressing a heterologous transporter, GatA, from Aspergillus niger. Last, we demonstrate the use of this transporter for production of the platform chemical, meso-galactaric acid, directly from industrial Navel orange peel waste.
Pectin-rich biomasses, such as citrus peel and sugar beet pulp, hold promise as inexpensive feedstocks for microbial fermentations as enzymatic hydrolysis of their component polysaccharides can be accomplished inexpensively to yield high concentrations of fermentable sugars and d -galacturonic acid ( d -galUA). In this study, we tackle a number of challenges associated with engineering a microbial strain to convert pectin-rich hydrolysates into commodity and specialty chemicals. First, we engineer d -galUA utilization into yeast, Saccharomyces cerevisiae . Second, we identify that the mechanism of d -galUA uptake into yeast is mediated by hexose transporters and that consumption of d -galUA is inhibited by d -glucose. Third, we enable co-utilization of d -galUA and d -glucose by identifying and expressing a heterologous transporter, GatA, from Aspergillus niger . Last, we demonstrate the use of this transporter for production of the platform chemical, meso -galactaric acid, directly from industrial Navel orange peel waste. Pectin-rich agricultural byproducts are ideal feedstocks for biobased chemicals production. Here, the authors engineer the yeast, S. cerevisiae , in several steps to co-utilize d -galacturonic acid and d -glucose and demonstrate the potential of producing meso -galactaric acid from industrial orange peel.
ArticleNumber 5059
Author Seibert, Tanja
Benz, J Philipp
Protzko, Ryan J
de Reus, Elise
Latimer, Luke N
Martinho, Ze
Dueber, John E
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  organization: Biological Systems & Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA. jdueber@berkeley.edu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30498222$$D View this record in MEDLINE/PubMed
https://www.osti.gov/servlets/purl/1571943$$D View this record in Osti.gov
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SSID ssj0000391844
Score 2.5476363
Snippet Pectin-rich biomasses, such as citrus peel and sugar beet pulp, hold promise as inexpensive feedstocks for microbial fermentations as enzymatic hydrolysis of...
Abstract Pectin-rich biomasses, such as citrus peel and sugar beet pulp, hold promise as inexpensive feedstocks for microbial fermentations as enzymatic...
Pectin-rich agricultural byproducts are ideal feedstocks for biobased chemicals production. Here, the authors engineer the yeast, S. cerevisiae, in several...
SourceID doaj
pubmedcentral
osti
proquest
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 5059
SubjectTerms Aspergillus niger - metabolism
Baking yeast
BASIC BIOLOGICAL SCIENCES
Citrus - metabolism
D-Galacturonic acid
Engineering
Fermentation - genetics
Fermentation - physiology
Glucose
Glucose - metabolism
Hexose
Hexuronic Acids - metabolism
Hydrolysates
Microorganisms
Oranges
Organic chemistry
Pectin
Polysaccharides
Pulp
Saccharides
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Sugar
Utilization
Yeast
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Title Engineering Saccharomyces cerevisiae for co-utilization of D-galacturonic acid and D-glucose from citrus peel waste
URI https://www.ncbi.nlm.nih.gov/pubmed/30498222
https://www.proquest.com/docview/2139592268/abstract/
https://search.proquest.com/docview/2141040737
https://www.osti.gov/servlets/purl/1571943
https://pubmed.ncbi.nlm.nih.gov/PMC6265301
https://doaj.org/article/a646d264ae744c1a83be4e4b6f0408e5
Volume 9
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