Association of single nucleotide polymorphisms in interferon signaling pathway genes and interferon-stimulated genes with the response to interferon therapy for chronic hepatitis C
Interferon signaling pathway genes (IPGs) and interferon-stimulated genes (ISGs) are associated with the host response to hepatitis C virus (HCV) infection. We studied single nucleotide polymorphisms (SNPs) in IPGs and ISGs for their associations with response to pegylated interferon α-2a (Peg-IFN-α...
Saved in:
| Published in | Journal of hepatology Vol. 49; no. 2; pp. 184 - 191 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford
Elsevier B.V
01.08.2008
Elsevier |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Interferon signaling pathway genes (IPGs) and interferon-stimulated genes (ISGs) are associated with the host response to hepatitis C virus (HCV) infection. We studied single nucleotide polymorphisms (SNPs) in IPGs and ISGs for their associations with response to pegylated interferon α-2a (Peg-IFN-α) plus ribavirin therapy in HCV genotype-1 infected patients.
A two-stage study design was used. First, out of 118 SNPs selected, 91 SNPs from 5 IPGs and 12 ISGs were genotyped in a cohort of 374 treatment-naı¨ve HCV patients and assessed for association with sustained virologic response (SVR). Next, 14 potentially functional SNPs from the
OASL gene were studied in this cohort.
Three
OASL SNPs (rs3213545 and rs1169279 from stage I, and rs2859398 from stage II), were significantly associated with SVR [rs3213545:
p
=
0.03, RR
=
1.27 (1.03–1.58); rs1169279:
p
=
0.02, RR
=
1.32 (1.05–1.65)
p
=
0.02; rs2859398:
p
=
0.02, RR
=
1.29 (1.04–1.61)] after adjusting for other covariates. Further analysis showed that these three SNPs independently associated with SVR. Additionally, a similar trend towards the associations of these three SNPs with SVR was observed in a smaller, independent HCV cohort consisting of subjects from a number of clinical practice settings.
Our study suggests that
OASL variants are involved in the host response to IFN-based therapy in HCV patients. |
|---|---|
| AbstractList | Interferon signaling pathway genes (IPGs) and interferon-stimulated genes (ISGs) are associated with the host response to hepatitis C virus (HCV) infection. We studied single nucleotide polymorphisms (SNPs) in IPGs and ISGs for their associations with response to pegylated interferon α-2a (Peg-IFN-α) plus ribavirin therapy in HCV genotype-1 infected patients.
A two-stage study design was used. First, out of 118 SNPs selected, 91 SNPs from 5 IPGs and 12 ISGs were genotyped in a cohort of 374 treatment-naı¨ve HCV patients and assessed for association with sustained virologic response (SVR). Next, 14 potentially functional SNPs from the
OASL gene were studied in this cohort.
Three
OASL SNPs (rs3213545 and rs1169279 from stage I, and rs2859398 from stage II), were significantly associated with SVR [rs3213545:
p
=
0.03, RR
=
1.27 (1.03–1.58); rs1169279:
p
=
0.02, RR
=
1.32 (1.05–1.65)
p
=
0.02; rs2859398:
p
=
0.02, RR
=
1.29 (1.04–1.61)] after adjusting for other covariates. Further analysis showed that these three SNPs independently associated with SVR. Additionally, a similar trend towards the associations of these three SNPs with SVR was observed in a smaller, independent HCV cohort consisting of subjects from a number of clinical practice settings.
Our study suggests that
OASL variants are involved in the host response to IFN-based therapy in HCV patients. Interferon signaling pathway genes (IPGs) and interferon-stimulated genes (ISGs) are associated with the host response to hepatitis C virus (HCV) infection. We studied single nucleotide polymorphisms (SNPs) in IPGs and ISGs for their associations with response to pegylated interferon alpha-2a (Peg-IFN-alpha) plus ribavirin therapy in HCV genotype-1 infected patients.BACKGROUND/AIMSInterferon signaling pathway genes (IPGs) and interferon-stimulated genes (ISGs) are associated with the host response to hepatitis C virus (HCV) infection. We studied single nucleotide polymorphisms (SNPs) in IPGs and ISGs for their associations with response to pegylated interferon alpha-2a (Peg-IFN-alpha) plus ribavirin therapy in HCV genotype-1 infected patients.A two-stage study design was used. First, out of 118 SNPs selected, 91 SNPs from 5 IPGs and 12 ISGs were genotyped in a cohort of 374 treatment-naïve HCV patients and assessed for association with sustained virologic response (SVR). Next, 14 potentially functional SNPs from the OASL gene were studied in this cohort.METHODSA two-stage study design was used. First, out of 118 SNPs selected, 91 SNPs from 5 IPGs and 12 ISGs were genotyped in a cohort of 374 treatment-naïve HCV patients and assessed for association with sustained virologic response (SVR). Next, 14 potentially functional SNPs from the OASL gene were studied in this cohort.Three OASL SNPs (rs3213545 and rs1169279 from stage I, and rs2859398 from stage II), were significantly associated with SVR [rs3213545: p=0.03, RR=1.27 (1.03-1.58); rs1169279: p=0.02, RR=1.32 (1.05-1.65) p=0.02; rs2859398: p=0.02, RR=1.29 (1.04-1.61)] after adjusting for other covariates. Further analysis showed that these three SNPs independently associated with SVR. Additionally, a similar trend towards the associations of these three SNPs with SVR was observed in a smaller, independent HCV cohort consisting of subjects from a number of clinical practice settings.RESULTSThree OASL SNPs (rs3213545 and rs1169279 from stage I, and rs2859398 from stage II), were significantly associated with SVR [rs3213545: p=0.03, RR=1.27 (1.03-1.58); rs1169279: p=0.02, RR=1.32 (1.05-1.65) p=0.02; rs2859398: p=0.02, RR=1.29 (1.04-1.61)] after adjusting for other covariates. Further analysis showed that these three SNPs independently associated with SVR. Additionally, a similar trend towards the associations of these three SNPs with SVR was observed in a smaller, independent HCV cohort consisting of subjects from a number of clinical practice settings.Our study suggests that OASL variants are involved in the host response to IFN-based therapy in HCV patients.CONCLUSIONSOur study suggests that OASL variants are involved in the host response to IFN-based therapy in HCV patients. Background/Aims Interferon signaling pathway genes (IPGs) and interferon-stimulated genes (ISGs) are associated with the host response to hepatitis C virus (HCV) infection. We studied single nucleotide polymorphisms (SNPs) in IPGs and ISGs for their associations with response to pegylated interferon α-2a (Peg-IFN-α) plus ribavirin therapy in HCV genotype-1 infected patients. Methods A two-stage study design was used. First, out of 118 SNPs selected, 91 SNPs from 5 IPGs and 12 ISGs were genotyped in a cohort of 374 treatment-naı¨ve HCV patients and assessed for association with sustained virologic response (SVR). Next, 14 potentially functional SNPs from the OASL gene were studied in this cohort. Results Three OASL SNPs (rs3213545 and rs1169279 from stage I, and rs2859398 from stage II), were significantly associated with SVR [rs3213545: p = 0.03, RR = 1.27 (1.03–1.58); rs1169279: p = 0.02, RR = 1.32 (1.05–1.65) p = 0.02; rs2859398: p = 0.02, RR = 1.29 (1.04–1.61)] after adjusting for other covariates. Further analysis showed that these three SNPs independently associated with SVR. Additionally, a similar trend towards the associations of these three SNPs with SVR was observed in a smaller, independent HCV cohort consisting of subjects from a number of clinical practice settings. Conclusions Our study suggests that OASL variants are involved in the host response to IFN-based therapy in HCV patients. Interferon signaling pathway genes (IPGs) and interferon-stimulated genes (ISGs) are associated with the host response to hepatitis C virus (HCV) infection. We studied single nucleotide polymorphisms (SNPs) in IPGs and ISGs for their associations with response to pegylated interferon alpha-2a (Peg-IFN-alpha) plus ribavirin therapy in HCV genotype-1 infected patients. A two-stage study design was used. First, out of 118 SNPs selected, 91 SNPs from 5 IPGs and 12 ISGs were genotyped in a cohort of 374 treatment-naïve HCV patients and assessed for association with sustained virologic response (SVR). Next, 14 potentially functional SNPs from the OASL gene were studied in this cohort. Three OASL SNPs (rs3213545 and rs1169279 from stage I, and rs2859398 from stage II), were significantly associated with SVR [rs3213545: p=0.03, RR=1.27 (1.03-1.58); rs1169279: p=0.02, RR=1.32 (1.05-1.65) p=0.02; rs2859398: p=0.02, RR=1.29 (1.04-1.61)] after adjusting for other covariates. Further analysis showed that these three SNPs independently associated with SVR. Additionally, a similar trend towards the associations of these three SNPs with SVR was observed in a smaller, independent HCV cohort consisting of subjects from a number of clinical practice settings. Our study suggests that OASL variants are involved in the host response to IFN-based therapy in HCV patients. |
| Author | Su, Xiaowen Tong, Xiaomei Ramcharran, Darmendra Rhodes, Shannon L. Yee, Leland J. Im, KyungAh Liang, T. Jake Rosen, Hugo R. Tang, YongMing Taylor, Milton W. Yang, Huiying Howell, Charles |
| AuthorAffiliation | 5 Integrated Program in Immunology and Hepatitis C Research Center, Division of Gastroenterology & Hepatology, University of Colorado, Denver, CO 6 Department of Biology, Indiana University, Bloomington, IN 4 Department of Medicine, Division of Gastroenterology and Hepatology , University of Maryland School of Medicine, Baltimore, MD 3 Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh; University of Pittsburgh, Pittsburgh, PA 2 Department of Epidemiology, Graduate School of Public Health and Division of Infectious Diseases, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 1 Medical Genetic Institute, Cedars-Sinai Medical Center, Los Angeles, CA 7 Liver Diseases Branch, NIDDK, National Institutes of Health, Bethesda, MD |
| AuthorAffiliation_xml | – name: 2 Department of Epidemiology, Graduate School of Public Health and Division of Infectious Diseases, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA – name: 3 Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh; University of Pittsburgh, Pittsburgh, PA – name: 6 Department of Biology, Indiana University, Bloomington, IN – name: 5 Integrated Program in Immunology and Hepatitis C Research Center, Division of Gastroenterology & Hepatology, University of Colorado, Denver, CO – name: 7 Liver Diseases Branch, NIDDK, National Institutes of Health, Bethesda, MD – name: 4 Department of Medicine, Division of Gastroenterology and Hepatology , University of Maryland School of Medicine, Baltimore, MD – name: 1 Medical Genetic Institute, Cedars-Sinai Medical Center, Los Angeles, CA |
| Author_xml | – sequence: 1 givenname: Xiaowen surname: Su fullname: Su, Xiaowen organization: Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA – sequence: 2 givenname: Leland J. surname: Yee fullname: Yee, Leland J. email: YeeL@edc.pitt.edu organization: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, A511 Crabtree Hall, 130 DeSoto Street, Pittsburgh, PA 15232, USA – sequence: 3 givenname: KyungAh surname: Im fullname: Im, KyungAh organization: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, A511 Crabtree Hall, 130 DeSoto Street, Pittsburgh, PA 15232, USA – sequence: 4 givenname: Shannon L. surname: Rhodes fullname: Rhodes, Shannon L. organization: Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA – sequence: 5 givenname: YongMing surname: Tang fullname: Tang, YongMing organization: Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA – sequence: 6 givenname: Xiaomei surname: Tong fullname: Tong, Xiaomei organization: Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA – sequence: 7 givenname: Charles surname: Howell fullname: Howell, Charles organization: Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland, School of Medicine, Baltimore, MD, USA – sequence: 8 givenname: Darmendra surname: Ramcharran fullname: Ramcharran, Darmendra organization: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, A511 Crabtree Hall, 130 DeSoto Street, Pittsburgh, PA 15232, USA – sequence: 9 givenname: Hugo R. surname: Rosen fullname: Rosen, Hugo R. organization: Integrated Program in Immunology and Hepatitis C Research Center, Division of Gastroenterology & Hepatology, University of Colorado, Denver, CO, USA – sequence: 10 givenname: Milton W. surname: Taylor fullname: Taylor, Milton W. organization: Department of Biology, Indiana University, Bloomington, IN, USA – sequence: 11 givenname: T. Jake surname: Liang fullname: Liang, T. Jake organization: Division of Digestive Diseases, NIDDK, National Institutes of Health, Bethesda, MD, USA – sequence: 12 givenname: Huiying surname: Yang fullname: Yang, Huiying organization: Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20574135$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/18571276$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkt1u1DAQhSNURLeFF-AC-YbeZRk7P5sgVKla8SdV4gK4trzOZOMlsYPHabXvxQPiZZeyVKJIkax4zjnjsb-z5MQ6i0nynMOcAy9fbeabDse5AKjmkM-B80fJjJcAKZQ5P0lmUVSllVhUp8kZ0QYAMqjzJ8kpr4oFF4tylvy4InLaqGCcZa5lZOy6R2Yn3aMLpkE2un47OD92hgZixsYvoG_RRwOZtVV9tLBRhe5WbdkaLRJTtjmSpRTMMPUqYHOo35rQsdAh80ijs4QsuOPcWPJq3LLWeaa7uGM0i6PGUwZDbPk0edyqnvDZYT1Pvr57-2X5Ib3-9P7j8uo61UVVh7QCXa0yHn8QSq4yXqLO87oURd4sVlmsFYKrmpcrUWutlBK5brkoRF7oQrR1dp5c7nPHaTVgo9EGr3o5ejMov5VOGfl3xZpOrt2NFCXUdZHHgItDgHffJ6QgB0Ma-15ZdBPJss5AxBNF4YvjTnctfj9UFLw8CBRp1bdeWW3oTiegWOQ8K6JO7HXaOyKP7Z8okDtq5EbuqJE7aiTkMlITTdU9kzbhFxJxKtM_bH2zt2J8hxuDXpI2aDU2xqMOsnHmYfvlPbuOOJk44TfcIm3c5CNgJLkkIUF-3hG9AxoqAFGL3Q2__nfA_7r_BO2vC9w |
| CODEN | JOHEEC |
| CitedBy_id | crossref_primary_10_2217_imt_11_105 crossref_primary_10_3892_mmr_2017_6351 crossref_primary_10_3748_wjg_v22_i41_9186 crossref_primary_10_1002_bdr2_2232 crossref_primary_10_1016_j_mrrev_2012_02_001 crossref_primary_10_1007_s11901_010_0029_3 crossref_primary_10_1016_j_coviro_2015_01_010 crossref_primary_10_1002_hep_26263 crossref_primary_10_1155_2014_493087 crossref_primary_10_1186_1743_422X_7_265 crossref_primary_10_1016_j_jhep_2009_10_034 crossref_primary_10_1038_gene_2011_1 crossref_primary_10_1007_s40291_013_0053_4 crossref_primary_10_3389_fimmu_2024_1402951 crossref_primary_10_1016_j_bpg_2010_07_009 crossref_primary_10_1002_hep_22877 crossref_primary_10_1016_j_antiviral_2016_04_009 crossref_primary_10_1111_j_1478_3231_2010_02389_x crossref_primary_10_3389_fphys_2024_1297810 crossref_primary_10_1016_j_coviro_2023_101329 crossref_primary_10_1038_clpt_2011_189 crossref_primary_10_1016_j_jhep_2008_11_010 crossref_primary_10_1038_emm_2014_110 crossref_primary_10_3389_fgene_2021_647487 crossref_primary_10_1007_s12291_013_0309_0 crossref_primary_10_24190_ISSN2564_615X_2017_02_02 crossref_primary_10_1016_j_antiviral_2011_01_006 crossref_primary_10_15252_msb_202211294 crossref_primary_10_2217_bmm_12_9 crossref_primary_10_1053_j_gastro_2010_02_033 crossref_primary_10_1111_jvh_12899 crossref_primary_10_1007_s12035_023_03381_0 crossref_primary_10_1073_pnas_0913491107 crossref_primary_10_2147_IJGM_S474284 crossref_primary_10_1016_j_ajg_2018_06_002 crossref_primary_10_1186_1479_5876_7_45 crossref_primary_10_1016_j_mgene_2021_100884 crossref_primary_10_1186_s12876_016_0440_5 crossref_primary_10_3390_genes14020527 crossref_primary_10_1177_1756283X09339079 crossref_primary_10_3109_09513590_2012_743011 |
| Cites_doi | 10.1111/j.1478-3231.2006.01438.x 10.1002/hep.20139 10.1046/j.1432-1327.1999.00361.x 10.1146/annurev.micro.55.1.255 10.4049/jimmunol.167.3.1654 10.1111/j.1365-2893.2004.00509.x 10.1159/000025035 10.1089/107999099313992 10.1210/en.2003-1724 10.1016/j.jhep.2006.01.037 10.1053/j.gastro.2005.01.059 10.1128/JVI.78.24.13779-13792.2004 10.1074/jbc.273.6.3236 10.1093/aje/kwh090 10.1002/hep.21636 10.1086/497340 10.1038/nature04083 10.1093/nar/gkg616 10.1089/jir.2004.24.659 10.1128/JVI.77.10.5933-5947.2003 10.1053/j.gastro.2006.06.008 10.1016/S1542-3565(04)00615-9 10.1093/bioinformatics/bth457 10.1038/nature04082 10.1159/000050075 10.1038/sj.gene.6363984 10.1097/01.GIM.0000076971.55421.AD 10.1093/genetics/155.2.945 10.1016/S0167-4781(02)00401-3 |
| ContentType | Journal Article |
| Contributor | Everhart, James Zacks, Steven Jeffers, Lennox J Kelley, Stephanie Cline, Jennifer Wang, Dai Yao, Ermei Yang, Huiying Rosen, Hugo R Hinds, Melissa Geahigan, Tiffany Yee, Leland J Tang, George Belle, Steven H Davis, Paris Heberlein, Jake Lewis, Jane Block, Geoffrey Taylor, Milton W Kelsey, Sherry Wei, Yuling Koozer, Laurie Lawlor, Sharon Martin, Maria Haritos, Marika Cannon, Nathan Dougherty, Karen Wang, Ping Hermitt, Carol Bilonick, Richard A Gibson, Kelly Fried, Michael W Ferris, Mary Fontana, Robert J Kleiner, David E Baker, Shawn McPherson DeMedina, Maria Klarquist, Jared Wiley, Thelma E Shrestha, Roshan Straley, Stephanie Tsukahara, Takuma Brown, Jr, Robert S Afdhal, Nezam Agudelo, Eliana Tavis, John E Brown, Shirley Conjeevaram, Hari S Im, KyungAh Dove, Lorna Di Bisceglie, Adrian Burton, James R Seeff, Leonard B Weston, Scott Doo, Edward Callison, Karen Smith, Scott R Williams, Monique Robuck, Patricia Theodore, Dickens Stovel, Shana Wahed, Abdus Hoofnagle, Jay H Liang, T Jake Terrault, Norah Sanda, Corneliu Zhang, Song Thomas, Stephen B Donlin, Ma |
| Contributor_xml | – sequence: 1 givenname: Nezam surname: Afdhal fullname: Afdhal, Nezam – sequence: 2 givenname: Tiffany surname: Geahigan fullname: Geahigan, Tiffany – sequence: 3 givenname: Robert S surname: Brown, Jr fullname: Brown, Jr, Robert S – sequence: 4 givenname: Lorna surname: Dove fullname: Dove, Lorna – sequence: 5 givenname: Shana surname: Stovel fullname: Stovel, Shana – sequence: 6 givenname: Maria surname: Martin fullname: Martin, Maria – sequence: 7 givenname: Norah surname: Terrault fullname: Terrault, Norah – sequence: 8 givenname: Stephanie surname: Straley fullname: Straley, Stephanie – sequence: 9 givenname: Eliana surname: Agudelo fullname: Agudelo, Eliana – sequence: 10 givenname: Melissa surname: Hinds fullname: Hinds, Melissa – sequence: 11 givenname: Jake surname: Heberlein fullname: Heberlein, Jake – sequence: 12 givenname: Thelma E surname: Wiley fullname: Wiley, Thelma E – sequence: 13 givenname: Monique surname: Williams fullname: Williams, Monique – sequence: 14 givenname: Charles D surname: Howell fullname: Howell, Charles D – sequence: 15 givenname: Kelly surname: Gibson fullname: Gibson, Kelly – sequence: 16 givenname: Karen surname: Callison fullname: Callison, Karen – sequence: 17 givenname: Jane surname: Lewis fullname: Lewis, Jane – sequence: 18 givenname: Lennox J surname: Jeffers fullname: Jeffers, Lennox J – sequence: 19 givenname: Shawn McPherson surname: Baker fullname: Baker, Shawn McPherson – sequence: 20 givenname: Maria surname: DeMedina fullname: DeMedina, Maria – sequence: 21 givenname: Carol surname: Hermitt fullname: Hermitt, Carol – sequence: 22 givenname: Hari S surname: Conjeevaram fullname: Conjeevaram, Hari S – sequence: 23 givenname: Robert J surname: Fontana fullname: Fontana, Robert J – sequence: 24 givenname: Donna surname: Harsh fullname: Harsh, Donna – sequence: 25 givenname: Michael W surname: Fried fullname: Fried, Michael W – sequence: 26 givenname: Scott R surname: Smith fullname: Smith, Scott R – sequence: 27 givenname: Dickens surname: Theodore fullname: Theodore, Dickens – sequence: 28 givenname: Steven surname: Zacks fullname: Zacks, Steven – sequence: 29 givenname: Roshan surname: Shrestha fullname: Shrestha, Roshan – sequence: 30 givenname: Karen surname: Dougherty fullname: Dougherty, Karen – sequence: 31 givenname: Paris surname: Davis fullname: Davis, Paris – sequence: 32 givenname: Shirley surname: Brown fullname: Brown, Shirley – sequence: 33 givenname: John E surname: Tavis fullname: Tavis, John E – sequence: 34 givenname: Adrian surname: Di Bisceglie fullname: Di Bisceglie, Adrian – sequence: 35 givenname: Ermei surname: Yao fullname: Yao, Ermei – sequence: 36 givenname: Maureen surname: Donlin fullname: Donlin, Maureen – sequence: 37 givenname: Nathan surname: Cannon fullname: Cannon, Nathan – sequence: 38 givenname: Ping surname: Wang fullname: Wang, Ping – sequence: 39 givenname: Huiying surname: Yang fullname: Yang, Huiying – sequence: 40 givenname: George surname: Tang fullname: Tang, George – sequence: 41 givenname: Dai surname: Wang fullname: Wang, Dai – sequence: 42 givenname: Hugo R surname: Rosen fullname: Rosen, Hugo R – sequence: 43 givenname: James R surname: Burton fullname: Burton, James R – sequence: 44 givenname: Jared surname: Klarquist fullname: Klarquist, Jared – sequence: 45 givenname: Scott surname: Weston fullname: Weston, Scott – sequence: 46 givenname: Milton W surname: Taylor fullname: Taylor, Milton W – sequence: 47 givenname: Corneliu surname: Sanda fullname: Sanda, Corneliu – sequence: 48 givenname: Takuma surname: Tsukahara fullname: Tsukahara, Takuma – sequence: 49 givenname: Mary surname: Ferris fullname: Ferris, Mary – sequence: 50 givenname: Steven H surname: Belle fullname: Belle, Steven H – sequence: 51 givenname: Richard A surname: Bilonick fullname: Bilonick, Richard A – sequence: 52 givenname: Geoffrey surname: Block fullname: Block, Geoffrey – sequence: 53 givenname: Jennifer surname: Cline fullname: Cline, Jennifer – sequence: 54 givenname: Marika surname: Haritos fullname: Haritos, Marika – sequence: 55 givenname: KyungAh surname: Im fullname: Im, KyungAh – sequence: 56 givenname: Stephanie surname: Kelley fullname: Kelley, Stephanie – sequence: 57 givenname: Sherry surname: Kelsey fullname: Kelsey, Sherry – sequence: 58 givenname: Laurie surname: Koozer fullname: Koozer, Laurie – sequence: 59 givenname: Sharon surname: Lawlor fullname: Lawlor, Sharon – sequence: 60 givenname: Stephen B surname: Thomas fullname: Thomas, Stephen B – sequence: 61 givenname: Abdus surname: Wahed fullname: Wahed, Abdus – sequence: 62 givenname: Yuling surname: Wei fullname: Wei, Yuling – sequence: 63 givenname: Leland J surname: Yee fullname: Yee, Leland J – sequence: 64 givenname: Song surname: Zhang fullname: Zhang, Song – sequence: 65 givenname: Patricia surname: Robuck fullname: Robuck, Patricia – sequence: 66 givenname: James surname: Everhart fullname: Everhart, James – sequence: 67 givenname: Jay H surname: Hoofnagle fullname: Hoofnagle, Jay H – sequence: 68 givenname: Edward surname: Doo fullname: Doo, Edward – sequence: 69 givenname: T Jake surname: Liang fullname: Liang, T Jake – sequence: 70 givenname: Leonard B surname: Seeff fullname: Seeff, Leonard B – sequence: 71 givenname: David E surname: Kleiner fullname: Kleiner, David E |
| Copyright | 2008 European Association for the Study of the Liver European Association for the Study of the Liver 2008 INIST-CNRS |
| Copyright_xml | – notice: 2008 European Association for the Study of the Liver – notice: European Association for the Study of the Liver – notice: 2008 INIST-CNRS |
| CorporateAuthor | for the Virahep-C Study Group Virahep-C Study Group |
| CorporateAuthor_xml | – name: for the Virahep-C Study Group – name: Virahep-C Study Group |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 5PM |
| DOI | 10.1016/j.jhep.2008.04.011 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1600-0641 |
| EndPage | 191 |
| ExternalDocumentID | PMC2609954 18571276 20574135 10_1016_j_jhep_2008_04_011 S0168827808002924 1_s2_0_S0168827808002924 |
| Genre | Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIDDK NIH HHS grantid: U01 DK060352 – fundername: NCRR NIH HHS grantid: M01 RR000046 – fundername: NIDDK NIH HHS grantid: U01 DK060344 – fundername: NIDDK NIH HHS grantid: U01 DK060341 – fundername: NCRR NIH HHS grantid: M01 RR000042 – fundername: NIDDK NIH HHS grantid: U01 DK60342 – fundername: NCRR NIH HHS grantid: M01 RR00645 – fundername: NCRR NIH HHS grantid: M01 RR016500 – fundername: NIDDK NIH HHS grantid: U01 DK60345 – fundername: NIDDK NIH HHS grantid: U01 DK60349 |
| GroupedDBID | --- --K --M .1- .55 .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 29K 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AABNK AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQQT AAQXK AATTM AAXKI AAXUO AAYWO ABBQC ABFNM ABFRF ABJNI ABMAC ABMZM ABWVN ABXDB ACDAQ ACGFO ACGFS ACIEU ACIUM ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO ADVLN AEBSH AEFWE AEIPS AEKER AENEX AEUPX AEVXI AFFNX AFJKZ AFPUW AFRHN AFTJW AFXIZ AGCQF AGHFR AGQPQ AGUBO AGYEJ AHHHB AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 D-I DU5 EBS EFJIC EFKBS EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HDZ HMK HMO HVGLF HX~ HZ~ IHE J1W KOM LZ1 M27 M41 MJL MO0 N9A O-L O9- OAUVE OC. ON0 OVD OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SAE SCC SDF SDG SDP SEL SES SEW SPCBC SSH SSZ T5K TEORI UV1 WUQ X7M YOC Z5R ZGI ~G- AACTN AFCTW AFKWA AJOXV AMFUW RIG AAIAV ABLVK ABYKQ AHPSJ AJBFU EFLBG LCYCR AAYXX AGRNS CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 5PM |
| ID | FETCH-LOGICAL-c589t-80c8b31c58e061a316ec4496254d7b38b3521a916b29ccaaa24cf125245c52f93 |
| IEDL.DBID | .~1 |
| ISSN | 0168-8278 |
| IngestDate | Thu Aug 21 14:10:18 EDT 2025 Fri Jul 11 10:29:54 EDT 2025 Mon Jul 21 05:36:13 EDT 2025 Mon Jul 21 09:15:33 EDT 2025 Thu Apr 24 23:06:16 EDT 2025 Tue Jul 01 04:14:05 EDT 2025 Fri Feb 23 02:28:16 EST 2024 Sun Feb 23 10:19:29 EST 2025 Tue Aug 26 16:52:41 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | AA Therapy Pharmacogenetics Interferon therapy Interferon signaling pathway genes Interferon-stimulated genes SVR Race Genetics HCV Interferon Hepatitis C CA African Americans Caucasian Americans sustained viralogic response hepatitis C virus Cytokine Hepatic disease Epidemiology Infection Treatment Viral disease Gastroenterology Digestive diseases Single nucleotide polymorphism Viral hepatitis C |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c589t-80c8b31c58e061a316ec4496254d7b38b3521a916b29ccaaa24cf125245c52f93 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Current address: Department of Discovery, Medicine & Epidemiology, AstraZeneca Pharmaceuticals LP, Wilmington, DE. |
| OpenAccessLink | https://doi.org/10.1016/j.jhep.2008.04.011 |
| PMID | 18571276 |
| PQID | 69302496 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_2609954 proquest_miscellaneous_69302496 pubmed_primary_18571276 pascalfrancis_primary_20574135 crossref_primary_10_1016_j_jhep_2008_04_011 crossref_citationtrail_10_1016_j_jhep_2008_04_011 elsevier_sciencedirect_doi_10_1016_j_jhep_2008_04_011 elsevier_clinicalkeyesjournals_1_s2_0_S0168827808002924 elsevier_clinicalkey_doi_10_1016_j_jhep_2008_04_011 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2008-08-01 |
| PublicationDateYYYYMMDD | 2008-08-01 |
| PublicationDate_xml | – month: 08 year: 2008 text: 2008-08-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | Oxford |
| PublicationPlace_xml | – name: Oxford – name: Netherlands |
| PublicationTitle | Journal of hepatology |
| PublicationTitleAlternate | J Hepatol |
| PublicationYear | 2008 |
| Publisher | Elsevier B.V Elsevier |
| Publisher_xml | – name: Elsevier B.V – name: Elsevier |
| References | Suzuki, Arase, Suzuki, Tsubota, Akuta, Hosaka (bib13) 2004; 11 Zou (bib18) 2004; 159 Bigger, Guerra, Brasky, Hubbard, Beard, Luxon (bib8) 2004; 78 Luo, Cassidy, Jeffers, Reddy, Bruno, Howell (bib11) 2005; 3 Di Bona, Cippitelli, Fionda, Cammà, Licata, Santoni (bib10) 2006; 45 Rebouillat, Hovanessian (bib23) 1999; 19 Yakub, Lillibridge, Moran, Gonzalez, Belmont, Gibbs (bib25) 2005; 192 Yang, Pares-Matos, Tesmer, Dai, Ashworth, Huai (bib29) 2002; 1577 Zhang, Jamaluddin, Wang, Tian, Garofalo, Casola (bib6) 2003; 77 Gao, Hong, Radaeva (bib4) 2004; 39 Ryther, Flynt, Harris, Phillips, Patton (bib27) 2004; 145 Cartegni, Wang, Zhu, Zhang, Krainer (bib26) 2003; 31 Hijikata, Ohta, Mishiro (bib21) 2000; 43 Sen (bib5) 2001; 55 Pritchard, Stephens, Donnelly (bib17) 2000; 155 Barrett, Fry, Maller, Daly (bib19) 2005; 21 Feld, Hoofnagle (bib2) 2005; 436 Marie, Rebouillat, Hovanessian (bib22) 1999; 262 Jeffers (bib3) 2007; 27 Chen, Borozan, Feld, Sun, Tannis, Coltescu (bib9) 2005; 128 Knapp, Yee, Frodsham, Hennig, Hellier, Zhang (bib12) 2003; 4 Conjeevaram, Fried, Jeffers, Terrault, Wiley-Lucas, Afdhal (bib14) 2006; 131 Yee, Tang, Kleiner, Wang, Im, Wahed (bib16) 2007; 46 Hijikata, Mishiro, Miyamoto, Furuichi, Hashimoto, Ohta (bib20) 2001; 44 Rosati, Valentin, Patenaude, Pavlakis (bib28) 2001; 167 Hartmann, Norby, Martensen, Jorgensen, James, Jacobsen (bib24) 1998; 273 Goodarzi, Guo, Taylor, Quiñones, Samayoa, Yang (bib15) 2003; 5 Giannelli, Guadagnino, Dentico, Antonelli, Antonaci (bib7) 2004; 24 Brown (bib1) 2005; 436 Ryther (10.1016/j.jhep.2008.04.011_bib27) 2004; 145 Giannelli (10.1016/j.jhep.2008.04.011_bib7) 2004; 24 Feld (10.1016/j.jhep.2008.04.011_bib2) 2005; 436 Suzuki (10.1016/j.jhep.2008.04.011_bib13) 2004; 11 Conjeevaram (10.1016/j.jhep.2008.04.011_bib14) 2006; 131 Sen (10.1016/j.jhep.2008.04.011_bib5) 2001; 55 Knapp (10.1016/j.jhep.2008.04.011_bib12) 2003; 4 Cartegni (10.1016/j.jhep.2008.04.011_bib26) 2003; 31 Yee (10.1016/j.jhep.2008.04.011_bib16) 2007; 46 Luo (10.1016/j.jhep.2008.04.011_bib11) 2005; 3 Di Bona (10.1016/j.jhep.2008.04.011_bib10) 2006; 45 Goodarzi (10.1016/j.jhep.2008.04.011_bib15) 2003; 5 Hijikata (10.1016/j.jhep.2008.04.011_bib21) 2000; 43 Gao (10.1016/j.jhep.2008.04.011_bib4) 2004; 39 Marie (10.1016/j.jhep.2008.04.011_bib22) 1999; 262 Zhang (10.1016/j.jhep.2008.04.011_bib6) 2003; 77 Barrett (10.1016/j.jhep.2008.04.011_bib19) 2005; 21 Yang (10.1016/j.jhep.2008.04.011_bib29) 2002; 1577 Chen (10.1016/j.jhep.2008.04.011_bib9) 2005; 128 Jeffers (10.1016/j.jhep.2008.04.011_bib3) 2007; 27 Pritchard (10.1016/j.jhep.2008.04.011_bib17) 2000; 155 Zou (10.1016/j.jhep.2008.04.011_bib18) 2004; 159 Rosati (10.1016/j.jhep.2008.04.011_bib28) 2001; 167 Hartmann (10.1016/j.jhep.2008.04.011_bib24) 1998; 273 Brown (10.1016/j.jhep.2008.04.011_bib1) 2005; 436 Yakub (10.1016/j.jhep.2008.04.011_bib25) 2005; 192 Hijikata (10.1016/j.jhep.2008.04.011_bib20) 2001; 44 Bigger (10.1016/j.jhep.2008.04.011_bib8) 2004; 78 Rebouillat (10.1016/j.jhep.2008.04.011_bib23) 1999; 19 |
| References_xml | – volume: 145 start-page: 2988 year: 2004 end-page: 2996 ident: bib27 article-title: GH1 splicing is regulated by multiple enhancers whose mutation produces a dominant-negative GH isoform that can be degraded by allele-specific small interfering RNA (siRNA) publication-title: Endocrinology – volume: 43 start-page: 124 year: 2000 end-page: 127 ident: bib21 article-title: Identification of a single nucleotide polymorphism in the MxA gene promoter (G/T at nt −88) correlated with the response of hepatitis C patients to interferon publication-title: Intervirology – volume: 24 start-page: 659 year: 2004 end-page: 663 ident: bib7 article-title: MxA and PKR expression in chronic hepatitis C publication-title: J Interferon Cytokine Res – volume: 5 start-page: 322 year: 2003 end-page: 327 ident: bib15 article-title: Determination and use of haplotypes: ethnic comparison and association of the lipoprotein lipase gene and coronary artery disease in Mexican-Americans publication-title: Genet Med – volume: 21 start-page: 263 year: 2005 end-page: 265 ident: bib19 article-title: Haploview: analysis and visualization of LD and haplotype maps publication-title: Bioinformatics – volume: 19 start-page: 295 year: 1999 end-page: 308 ident: bib23 article-title: The human 2′,5′-oligoadenylate synthetase family: interferon-induced proteins with unique enzymatic properties publication-title: J Interferon Cytokine Res – volume: 46 start-page: 74 year: 2007 end-page: 83 ident: bib16 article-title: Myxovirus-1 and protein kinase haplotypes and fibrosis in chronic hepatitis C virus publication-title: Hepatology – volume: 11 start-page: 271 year: 2004 end-page: 276 ident: bib13 article-title: Single nucleotide polymorphism of the MxA gene promoter influences the response to interferon monotherapy in patients with hepatitis C viral infection publication-title: J Viral Hepat – volume: 44 start-page: 379 year: 2001 end-page: 382 ident: bib20 article-title: Genetic polymorphism of the MxA gene promoter and interferon responsiveness of hepatitis C patients: revisited by analyzing two SNP sites (−123 and −88) in vivo and in vitro publication-title: Intervirology – volume: 45 start-page: 271 year: 2006 end-page: 279 ident: bib10 article-title: Oxidative stress inhibits IFN-alpha-induced antiviral gene expression by blocking the JAK-STAT pathway publication-title: J Hepatol – volume: 273 start-page: 3236 year: 1998 end-page: 3246 ident: bib24 article-title: Activation of 2′–5′ oligoadenylate synthetase by single-stranded and double-stranded RNA aptamers publication-title: J Biol Chem – volume: 1577 start-page: 102 year: 2002 end-page: 108 ident: bib29 article-title: Organization of the promoter region of the human NF-IL6 gene publication-title: Biochim Biophys Acta – volume: 3 start-page: 499 year: 2005 end-page: 506 ident: bib11 article-title: Interferon-stimulated gene expression in black and white hepatitis C patients during peginterferon alfa-2a combination therapy publication-title: Clin Gastroenterol Hepatol – volume: 159 start-page: 702 year: 2004 end-page: 706 ident: bib18 article-title: A modified poisson regression approach to prospective studies with binary data publication-title: Am J Epidemiol – volume: 128 start-page: 1437 year: 2005 end-page: 1444 ident: bib9 article-title: Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection publication-title: Gastroenterology – volume: 27 start-page: 313 year: 2007 end-page: 322 ident: bib3 article-title: Treating hepatitis C in African Americans publication-title: Liver Int – volume: 167 start-page: 1654 year: 2001 end-page: 1662 ident: bib28 article-title: CCAAT-enhancer-binding protein beta (C/EBP beta) activates CCR5 promoter: increased C/EBP beta and CCR5 in T lymphocytes from HIV-1-infected individuals publication-title: J Immunol – volume: 155 start-page: 945 year: 2000 end-page: 959 ident: bib17 article-title: Inference of population structure using multilocus genotype data publication-title: Genetics – volume: 436 start-page: 967 year: 2005 end-page: 972 ident: bib2 article-title: Mechanism of action of interferon and ribavirin in treatment of hepatitis C publication-title: Nature – volume: 39 start-page: 880 year: 2004 end-page: 890 ident: bib4 article-title: Host factors and failure of interferon-alpha treatment in hepatitis C virus publication-title: Hepatology – volume: 55 start-page: 255 year: 2001 end-page: 281 ident: bib5 article-title: Viruses and interferons publication-title: Annu Rev Microbiol – volume: 31 start-page: 3568 year: 2003 end-page: 3571 ident: bib26 article-title: ESEfinder: a web resource to identify exonic splicing enhancers publication-title: Nucleic Acids Res – volume: 77 start-page: 5933 year: 2003 end-page: 5947 ident: bib6 article-title: Ribavirin treatment up-regulates antiviral gene expression via the interferon-stimulated response element in respiratory syncytial virus-infected epithelial cells publication-title: J Virol – volume: 78 start-page: 13779 year: 2004 end-page: 13792 ident: bib8 article-title: Intrahepatic gene expression during chronic hepatitis C virus infection in chimpanzees publication-title: J Virol – volume: 131 start-page: 470 year: 2006 end-page: 477 ident: bib14 article-title: Peginterferon and ribavirin treatment in African American and Caucasian American patients with hepatitis C genotype 1 publication-title: Gastroenterology – volume: 436 start-page: 973 year: 2005 end-page: 978 ident: bib1 article-title: Hepatitis C and liver transplantation publication-title: Nature – volume: 192 start-page: 1741 year: 2005 end-page: 1748 ident: bib25 article-title: Single nucleotide polymorphisms in genes for 2′–5′-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection publication-title: J Infect Dis – volume: 4 start-page: 411 year: 2003 end-page: 419 ident: bib12 article-title: Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR publication-title: Genes Immun – volume: 262 start-page: 155 year: 1999 end-page: 165 ident: bib22 article-title: The expression of both domains of the 69/71 publication-title: Eur J Biochem – volume: 27 start-page: 313 year: 2007 ident: 10.1016/j.jhep.2008.04.011_bib3 article-title: Treating hepatitis C in African Americans publication-title: Liver Int doi: 10.1111/j.1478-3231.2006.01438.x – volume: 39 start-page: 880 year: 2004 ident: 10.1016/j.jhep.2008.04.011_bib4 article-title: Host factors and failure of interferon-alpha treatment in hepatitis C virus publication-title: Hepatology doi: 10.1002/hep.20139 – volume: 262 start-page: 155 year: 1999 ident: 10.1016/j.jhep.2008.04.011_bib22 article-title: The expression of both domains of the 69/71kDa 2′,5′ oligoadenylate synthetase generates a catalytically active enzyme and mediates an anti-viral response publication-title: Eur J Biochem doi: 10.1046/j.1432-1327.1999.00361.x – volume: 55 start-page: 255 year: 2001 ident: 10.1016/j.jhep.2008.04.011_bib5 article-title: Viruses and interferons publication-title: Annu Rev Microbiol doi: 10.1146/annurev.micro.55.1.255 – volume: 167 start-page: 1654 year: 2001 ident: 10.1016/j.jhep.2008.04.011_bib28 article-title: CCAAT-enhancer-binding protein beta (C/EBP beta) activates CCR5 promoter: increased C/EBP beta and CCR5 in T lymphocytes from HIV-1-infected individuals publication-title: J Immunol doi: 10.4049/jimmunol.167.3.1654 – volume: 11 start-page: 271 year: 2004 ident: 10.1016/j.jhep.2008.04.011_bib13 article-title: Single nucleotide polymorphism of the MxA gene promoter influences the response to interferon monotherapy in patients with hepatitis C viral infection publication-title: J Viral Hepat doi: 10.1111/j.1365-2893.2004.00509.x – volume: 43 start-page: 124 year: 2000 ident: 10.1016/j.jhep.2008.04.011_bib21 article-title: Identification of a single nucleotide polymorphism in the MxA gene promoter (G/T at nt −88) correlated with the response of hepatitis C patients to interferon publication-title: Intervirology doi: 10.1159/000025035 – volume: 19 start-page: 295 year: 1999 ident: 10.1016/j.jhep.2008.04.011_bib23 article-title: The human 2′,5′-oligoadenylate synthetase family: interferon-induced proteins with unique enzymatic properties publication-title: J Interferon Cytokine Res doi: 10.1089/107999099313992 – volume: 145 start-page: 2988 year: 2004 ident: 10.1016/j.jhep.2008.04.011_bib27 article-title: GH1 splicing is regulated by multiple enhancers whose mutation produces a dominant-negative GH isoform that can be degraded by allele-specific small interfering RNA (siRNA) publication-title: Endocrinology doi: 10.1210/en.2003-1724 – volume: 45 start-page: 271 year: 2006 ident: 10.1016/j.jhep.2008.04.011_bib10 article-title: Oxidative stress inhibits IFN-alpha-induced antiviral gene expression by blocking the JAK-STAT pathway publication-title: J Hepatol doi: 10.1016/j.jhep.2006.01.037 – volume: 128 start-page: 1437 year: 2005 ident: 10.1016/j.jhep.2008.04.011_bib9 article-title: Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection publication-title: Gastroenterology doi: 10.1053/j.gastro.2005.01.059 – volume: 78 start-page: 13779 year: 2004 ident: 10.1016/j.jhep.2008.04.011_bib8 article-title: Intrahepatic gene expression during chronic hepatitis C virus infection in chimpanzees publication-title: J Virol doi: 10.1128/JVI.78.24.13779-13792.2004 – volume: 273 start-page: 3236 year: 1998 ident: 10.1016/j.jhep.2008.04.011_bib24 article-title: Activation of 2′–5′ oligoadenylate synthetase by single-stranded and double-stranded RNA aptamers publication-title: J Biol Chem doi: 10.1074/jbc.273.6.3236 – volume: 159 start-page: 702 year: 2004 ident: 10.1016/j.jhep.2008.04.011_bib18 article-title: A modified poisson regression approach to prospective studies with binary data publication-title: Am J Epidemiol doi: 10.1093/aje/kwh090 – volume: 46 start-page: 74 year: 2007 ident: 10.1016/j.jhep.2008.04.011_bib16 article-title: Myxovirus-1 and protein kinase haplotypes and fibrosis in chronic hepatitis C virus publication-title: Hepatology doi: 10.1002/hep.21636 – volume: 192 start-page: 1741 year: 2005 ident: 10.1016/j.jhep.2008.04.011_bib25 article-title: Single nucleotide polymorphisms in genes for 2′–5′-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection publication-title: J Infect Dis doi: 10.1086/497340 – volume: 436 start-page: 973 year: 2005 ident: 10.1016/j.jhep.2008.04.011_bib1 article-title: Hepatitis C and liver transplantation publication-title: Nature doi: 10.1038/nature04083 – volume: 31 start-page: 3568 year: 2003 ident: 10.1016/j.jhep.2008.04.011_bib26 article-title: ESEfinder: a web resource to identify exonic splicing enhancers publication-title: Nucleic Acids Res doi: 10.1093/nar/gkg616 – volume: 24 start-page: 659 year: 2004 ident: 10.1016/j.jhep.2008.04.011_bib7 article-title: MxA and PKR expression in chronic hepatitis C publication-title: J Interferon Cytokine Res doi: 10.1089/jir.2004.24.659 – volume: 77 start-page: 5933 year: 2003 ident: 10.1016/j.jhep.2008.04.011_bib6 article-title: Ribavirin treatment up-regulates antiviral gene expression via the interferon-stimulated response element in respiratory syncytial virus-infected epithelial cells publication-title: J Virol doi: 10.1128/JVI.77.10.5933-5947.2003 – volume: 131 start-page: 470 year: 2006 ident: 10.1016/j.jhep.2008.04.011_bib14 article-title: Peginterferon and ribavirin treatment in African American and Caucasian American patients with hepatitis C genotype 1 publication-title: Gastroenterology doi: 10.1053/j.gastro.2006.06.008 – volume: 3 start-page: 499 year: 2005 ident: 10.1016/j.jhep.2008.04.011_bib11 article-title: Interferon-stimulated gene expression in black and white hepatitis C patients during peginterferon alfa-2a combination therapy publication-title: Clin Gastroenterol Hepatol doi: 10.1016/S1542-3565(04)00615-9 – volume: 21 start-page: 263 year: 2005 ident: 10.1016/j.jhep.2008.04.011_bib19 article-title: Haploview: analysis and visualization of LD and haplotype maps publication-title: Bioinformatics doi: 10.1093/bioinformatics/bth457 – volume: 436 start-page: 967 year: 2005 ident: 10.1016/j.jhep.2008.04.011_bib2 article-title: Mechanism of action of interferon and ribavirin in treatment of hepatitis C publication-title: Nature doi: 10.1038/nature04082 – volume: 44 start-page: 379 year: 2001 ident: 10.1016/j.jhep.2008.04.011_bib20 article-title: Genetic polymorphism of the MxA gene promoter and interferon responsiveness of hepatitis C patients: revisited by analyzing two SNP sites (−123 and −88) in vivo and in vitro publication-title: Intervirology doi: 10.1159/000050075 – volume: 4 start-page: 411 year: 2003 ident: 10.1016/j.jhep.2008.04.011_bib12 article-title: Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR publication-title: Genes Immun doi: 10.1038/sj.gene.6363984 – volume: 5 start-page: 322 year: 2003 ident: 10.1016/j.jhep.2008.04.011_bib15 article-title: Determination and use of haplotypes: ethnic comparison and association of the lipoprotein lipase gene and coronary artery disease in Mexican-Americans publication-title: Genet Med doi: 10.1097/01.GIM.0000076971.55421.AD – volume: 155 start-page: 945 year: 2000 ident: 10.1016/j.jhep.2008.04.011_bib17 article-title: Inference of population structure using multilocus genotype data publication-title: Genetics doi: 10.1093/genetics/155.2.945 – volume: 1577 start-page: 102 year: 2002 ident: 10.1016/j.jhep.2008.04.011_bib29 article-title: Organization of the promoter region of the human NF-IL6 gene publication-title: Biochim Biophys Acta doi: 10.1016/S0167-4781(02)00401-3 |
| SSID | ssj0003094 |
| Score | 2.1296892 |
| Snippet | Interferon signaling pathway genes (IPGs) and interferon-stimulated genes (ISGs) are associated with the host response to hepatitis C virus (HCV) infection. We... Background/Aims Interferon signaling pathway genes (IPGs) and interferon-stimulated genes (ISGs) are associated with the host response to hepatitis C virus... |
| SourceID | pubmedcentral proquest pubmed pascalfrancis crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 184 |
| SubjectTerms | Antiviral Agents - metabolism Antiviral Agents - therapeutic use Biological and medical sciences Cohort Studies Databases, Genetic Female Gastroenterology and Hepatology Gastroenterology. Liver. Pancreas. Abdomen Gene Frequency Genetics Genotype Hepatitis C Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - epidemiology Hepatitis C, Chronic - genetics Human viral diseases Humans Infectious diseases Interferon Interferon alpha-2 Interferon signaling pathway genes Interferon therapy Interferon-alpha - metabolism Interferon-alpha - therapeutic use Interferon-stimulated genes Interferons - genetics Interferons - metabolism Male Medical sciences Middle Aged Pharmacogenetics Polyethylene Glycols - metabolism Polyethylene Glycols - therapeutic use Polymorphism, Single Nucleotide Race Recombinant Proteins Regression Analysis Risk Factors Signal Transduction - drug effects Signal Transduction - genetics Therapy Viral diseases Viral hepatitis |
| Title | Association of single nucleotide polymorphisms in interferon signaling pathway genes and interferon-stimulated genes with the response to interferon therapy for chronic hepatitis C |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0168827808002924 https://www.clinicalkey.es/playcontent/1-s2.0-S0168827808002924 https://dx.doi.org/10.1016/j.jhep.2008.04.011 https://www.ncbi.nlm.nih.gov/pubmed/18571276 https://www.proquest.com/docview/69302496 https://pubmed.ncbi.nlm.nih.gov/PMC2609954 |
| Volume | 49 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fa9swEBalgzEYY7_ndcv0sLfhJrIly34sYSXt1jK2FfomZFtuXRLbxC4jL_2r-gf2LpLTZOs62FNwpLPR6XT6ZH93R8hHyYUc5UXuI7b34bzB_bSQgV-IMBGaxRFLMXb46DianPDDU3G6RcZ9LAzSKp3vtz596a3dP0OnzWFTlsMfAFYAHsp4iXngURjBziVa-e7VLc0jHCUuv3fsY28XOGM5XhfnpnF8Sr47Yuxvm9PjRregssLWurgLjP7OqVzbpPafkicOXdI9O4BnZMtUz8nDI_f9_AW5XpsNWhcUXxRMDa0wqXHdlbmhTT1dzGpQftnOWlpWFPNJzAszBwHkemgMX6dYx_iXXtAz9JRUV_laNx-cxgyLgpncteO7XgpAk84tIdfQrl6_r40BW1DAzzSzyXopqAwNuWzp-CU52f_8czzxXd0GPxNx0sGml8VpyODCAFrQIYtMxnkCJy2eyzSENsAMGnBpGiRgQFoHPCsAaAVcZCIokvAV2a7qyrwhFPBhCgCOyThkPItkGnNtwMlmJszjwOQeYf2EqcwlNcfaGlPVs9cuFE6yq7bJFUyyRz6tZBqb0uPe3mFvB6oPVgX3qmDHuVdK3iVlWuchWsVUG6iR-sOKPSJWkhsL4Z9PHGwY6WpoASByQCrCIx96q1XgQvC7kK5MfdkqrIYJKzXyyGtrw7dqiYVkgYQWuWHdqw6YnHyzpSrPl0nK4ZyMqQbf_udwdsgjy8xBquU7st3NL817gH9dOliu7wF5sDf-_vUb_h58mRzfAKDoYGM |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fb9MwELbGkAAJTfwmMDY_8Iay1okdJ4-o2lRg3QubtDfLSZwtU5tETSbUF_4q_kDuaqdr2RgSj4l9iXw-nz8n390R8lFyIYd5kfuI7X04b3A_LWTgFyJMhGZxxFKMHZ6cROMz_vVcnG-RUR8Lg7RK5_utT196a3dn4LQ5aMpy8B3ACsBDGS8xD7zqAXnIYfliGYODnzc8j3CYuATfsY_dXeSMJXldXZrGESr5wZCxv-1OTxvdgs4KW-ziLjT6J6lybZc6ekZ2HLykn-0InpMtU70gjybuB_pL8mttOmhdUPxSMDW0wqzGdVfmhjb1dDGrQftlO2tpWVFMKDEvzBwEkOyhMX6dYiHjH3pBL9BVUl3la9188BozrApmcteOH3spIE06t4xcQ7t6_bk2CGxBAUDTzGbrpaAytOSypaNX5Ozo8HQ09l3hBj8TcdLBrpfFacjgwgBc0CGLTMZ5Akctnss0hDYADRqAaRokYEFaBzwrAGkFXGQiKJLwNdmu6sq8JRQAYgoIjsk4ZDyLZBpzbcDLZibM48DkHmH9hKnMZTXH4hpT1dPXrhROsiu3yRVMskc-rWQam9Pj3t5hbweqj1YF_6pgy7lXSt4lZVrnIlrFVBuoobplxh4RK8mNlfDPN-5tGOlqaAFAcoAqwiP7vdUq8CH4Y0hXpr5uFZbDhKUaeeSNteEbtcRCskBCi9yw7lUHzE6-2VKVl8ss5XBQxlyD7_5zOPvk8fh0cqyOv5x8e0-eWJoO8i53yXY3vzYfAAt26d5yrf8GHm1gXA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Association+of+single+nucleotide+polymorphisms+in+interferon+signaling+pathway+genes+and+interferon-stimulated+genes+with+the+response+to+interferon+therapy+for+chronic+hepatitis+C&rft.jtitle=Journal+of+hepatology&rft.au=Su%2C+Xiaowen&rft.au=Yee%2C+Leland+J&rft.au=Im%2C+KyungAh&rft.au=Rhodes%2C+Shannon+L&rft.date=2008-08-01&rft.issn=0168-8278&rft.volume=49&rft.issue=2&rft.spage=184&rft_id=info:doi/10.1016%2Fj.jhep.2008.04.011&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F01688278%2FS0168827808X00091%2Fcov150h.gif |