A critical time window for the analgesic effect of central histamine in the partial sciatic ligation model of neuropathic pain

• Published in: Journal of Neuroinflammation Vol. 13; no. 1; p. 163
• Main Authors: Yu, Jie, Tang, Ying-Ying, Wang, Ran-Ran, Lou, Guo-Dong, Hu, Ting-Ting, Hou, Wei-Wei, Yue, Jia-Xing, Ohtsu, Hiroshi, Shi, Li-Yun, Zhang, Shi-Hong, Chen, Zhong
• Format: Journal Article
• Language: English
• Published: England Springer Science and Business Media LLC 24.06.2016; BioMed Central Ltd; BioMed Central
• Subjects: Analgesics; Analgesics - pharmacology; Analgesics - therapeutic use; Analysis; Animals; Cellular and Molecular Neuroscience; Central Nervous System; Central Nervous System - drug effects; Central Nervous System - metabolism; Cimetidine; Cimetidine - pharmacology; Disease Models, Animal; Drug Administration Routes; Health aspects; Histamine; Histamine H1 Antagonists; Histamine H1 Antagonists - pharmacology; Histamine H2 Antagonists; Histamine H2 Antagonists - pharmacology; Histidine; Histidine - pharmacology; Histidine - therapeutic use; Histidine Decarboxylase; Histidine Decarboxylase - deficiency; Histidine Decarboxylase - genetics; Hyperalgesia; Hyperalgesia - drug therapy; Hyperalgesia - etiology; Immunohistochemistry; Immunology; Interleukins; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurology; Pain Threshold; Pain Threshold - drug effects; Pathological physiology; Pyrilamine; Pyrilamine - pharmacology; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1; Receptors, Interleukin-1 - deficiency; Receptors, Interleukin-1 - genetics; Sciatic Neuropathy; Sciatic Neuropathy - drug therapy; Sciatic Neuropathy - metabolism; Sciatic Neuropathy - pathology; Histidine; Central histamine; IL-1β; Analgesic effect; Microglial activation; Neuropathic pain

It is known that histamine participates in pain modulation. However, the effect of central histamine on neuropathic pain is not fully understood. Here, we report a critical time window for the analgesic effect of central histamine in the partial sciatic nerve ligation model of neuropathic pain. Neur...