Why does ticagrelor induce dyspnea?

• Published in: Thrombosis and haemostasis Vol. 108; no. 6; p. 1031
• Main Authors: Cattaneo, Marco, Faioni, Elena M
• Format: Journal Article
• Language: English
• Published: Germany 01.12.2012
• Subjects: Adenosine - adverse effects; Adenosine - analogs & derivatives; Dyspnea - blood; Dyspnea - chemically induced; Dyspnea - physiopathology; Humans; Models, Biological; Platelet Aggregation Inhibitors - adverse effects; Purinergic P2Y Receptor Antagonists - adverse effects; Sensory Receptor Cells - drug effects; Sensory Receptor Cells - physiology; Ticlopidine - adverse effects; Ticlopidine - analogs & derivatives

In studies that compared the reversible P2Y12 inhibitor ticagrelor with the irreversible inhibitor clopidogrel, dyspnea was observed more frequently among ticagrelor-treated patients than among clopidogrel-treated patients. Because dyspnea was not associated with acidosis, pulmonary or cardiac dysfu...