Subunit Structure of the Mammalian Exocyst Complex

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 94; no. 26; pp. 14438 - 14443
• Main Authors: Kee, Y, Yoo, J S, Hazuka, C D, Peterson, K E, Hsu, S C, Scheller, R H
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences of the United States of America 23.12.1997; National Acad Sciences; National Academy of Sciences; The National Academy of Sciences of the USA
• Subjects: Amino Acid Sequence; Amino acids; Animals; Biological Sciences; Cell Membrane - metabolism; Cell membranes; Cellular biology; Cloning, Molecular; Complementary DNA; Deoxyribonucleic acid; DNA; DNA, Complementary - genetics; DNA, Complementary - isolation & purification; Exocytosis; Exocytosis - genetics; Genes; Mammals; Membrane Proteins - genetics; Membrane Proteins - metabolism; Messenger RNA; Molecular Sequence Data; PC12 cells; Proteins; Secretion; Sequence Alignment; SNARE proteins; Vesicular Transport Proteins; Yeast; Yeasts

The exocyst is a protein complex required for the late stages of secretion in yeast. Unlike the SNAREs (SNAP receptors), important secretory proteins that are broadly distributed on the target membrane, the exocyst is specifically located at sites of vesicle fusion. We have isolated cDNAs encoding t...