Subunit Structure of the Mammalian Exocyst Complex

The exocyst is a protein complex required for the late stages of secretion in yeast. Unlike the SNAREs (SNAP receptors), important secretory proteins that are broadly distributed on the target membrane, the exocyst is specifically located at sites of vesicle fusion. We have isolated cDNAs encoding t...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 94; no. 26; pp. 14438 - 14443
Main Authors Kee, Y, Yoo, J S, Hazuka, C D, Peterson, K E, Hsu, S C, Scheller, R H
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences of the United States of America 23.12.1997
National Acad Sciences
National Academy of Sciences
The National Academy of Sciences of the USA
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Abstract The exocyst is a protein complex required for the late stages of secretion in yeast. Unlike the SNAREs (SNAP receptors), important secretory proteins that are broadly distributed on the target membrane, the exocyst is specifically located at sites of vesicle fusion. We have isolated cDNAs encoding the rexo70, rsec5, and rsec15 subunits of the mammalian complex. The amino acid sequences encoded by these genes are between 21% and 24% identical to their yeast homologs. All three genes are broadly expressed and multiple transcripts are observed for rexo70 and rsec15. Characterization of cDNAs encoding the 84-kDa subunit of the mammalian complex revealed a novel protein. mAbs were generated to the mammalian rsec6 subunit of the exocyst complex. rsec6 immunoreactivity is found in a punctate distribution at terminals of PC12 cell processes at or near sites of granule exocytosis.
AbstractList The subunit structure of the exocyst, a protein complex required for the late stages of secretion in yeast, was determined. A novel protein was revealed.
The exocyst is a protein complex required for the late stages of secretion in yeast. Unlike the SNAREs (SNAP receptors), important secretory proteins that are broadly distributed on the target membrane, the exocyst is specifically located at sites of vesicle fusion. We have isolated cDNAs encoding the rexo70, rsec5, and rsec15 subunits of the mammalian complex. The amino acid sequences encoded by these genes are between 21% and 24% identical to their yeast homologs. All three genes are broadly expressed and multiple transcripts are observed for rexo70 and rsec15. Characterization of cDNAs encoding the 84-kDa subunit of the mammalian complex revealed a novel protein. mAbs were generated to the mammalian rsec6 subunit of the exocyst complex. rsec6 immunoreactivity is found in a punctate distribution at terminals of PC12 cell processes at or near sites of granule exocytosis.
Author Yun Kee
Christopher D. Hazuka
Jin-San Yoo
Karen E. Peterson
Shu-Chan Hsu
Richard H. Scheller
AuthorAffiliation Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford CA 94305-5428
AuthorAffiliation_xml – name: Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford CA 94305-5428
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  surname: Kee
  fullname: Kee, Y
  organization: Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford CA 94305-5428, USA
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  givenname: J S
  surname: Yoo
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/9405631$$D View this record in MEDLINE/PubMed
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To whom reprint requests should be addressed. e-mail: scheller@cmgm.stanford.edu.
Communicated by Corey S. Goodman, University of California, Berkeley, CA
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Snippet The exocyst is a protein complex required for the late stages of secretion in yeast. Unlike the SNAREs (SNAP receptors), important secretory proteins that are...
The subunit structure of the exocyst, a protein complex required for the late stages of secretion in yeast, was determined. A novel protein was revealed.
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StartPage 14438
SubjectTerms Amino Acid Sequence
Amino acids
Animals
Biological Sciences
Cell Membrane - metabolism
Cell membranes
Cellular biology
Cloning, Molecular
Complementary DNA
Deoxyribonucleic acid
DNA
DNA, Complementary - genetics
DNA, Complementary - isolation & purification
Exocytosis
Exocytosis - genetics
Genes
Mammals
Membrane Proteins - genetics
Membrane Proteins - metabolism
Messenger RNA
Molecular Sequence Data
PC12 cells
Proteins
Secretion
Sequence Alignment
SNARE proteins
Vesicular Transport Proteins
Yeast
Yeasts
Title Subunit Structure of the Mammalian Exocyst Complex
URI https://www.jstor.org/stable/43636
http://www.pnas.org/content/94/26/14438.abstract
https://www.ncbi.nlm.nih.gov/pubmed/9405631
https://www.proquest.com/docview/201348802
https://search.proquest.com/docview/16269031
https://search.proquest.com/docview/79478458
https://pubmed.ncbi.nlm.nih.gov/PMC25013
Volume 94
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