BNT162b2 mRNA vaccine elicited antibody response in blood and milk of breastfeeding women
The importance of breastmilk in postnatal life lies in the strong association between breastfeeding and the reduction in the risk of infection and infection-related infant mortality. However, data regarding the induction and dynamics of breastmilk antibodies following administration of the Pfizer-Bi...
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Published in | Nature communications Vol. 12; no. 1; p. 6222 |
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Language | English |
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28.10.2021
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Abstract | The importance of breastmilk in postnatal life lies in the strong association between breastfeeding and the reduction in the risk of infection and infection-related infant mortality. However, data regarding the induction and dynamics of breastmilk antibodies following administration of the Pfizer-BioNTech BNT162b2 COVID-19 mRNA vaccine is scarce, as pregnant and lactating women were not included in the initial vaccine clinical trials. Here, we investigate the dynamics of the vaccine-specific antibody response in breastmilk and serum in a prospective cohort of ten lactating women who received two doses of the mRNA vaccine. We show that the antibody response is rapid and highly synchronized between breastmilk and serum, reaching stabilization 14 days after the second dose. The response in breastmilk includes both IgG and IgA with neutralization capacity.
Maternal antibodies can reduce risk of infection of infants. Here, the authors show induction of IgG and IgA antibodies in breastmilk and serum of ten lactating women after immunization with the Pfizer-BioNTech BNT162b2 COVID-19 mRNA vaccine. |
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AbstractList | The importance of breastmilk in postnatal life lies in the strong association between breastfeeding and the reduction in the risk of infection and infection-related infant mortality. However, data regarding the induction and dynamics of breastmilk antibodies following administration of the Pfizer-BioNTech BNT162b2 COVID-19 mRNA vaccine is scarce, as pregnant and lactating women were not included in the initial vaccine clinical trials. Here, we investigate the dynamics of the vaccine-specific antibody response in breastmilk and serum in a prospective cohort of ten lactating women who received two doses of the mRNA vaccine. We show that the antibody response is rapid and highly synchronized between breastmilk and serum, reaching stabilization 14 days after the second dose. The response in breastmilk includes both IgG and IgA with neutralization capacity. The importance of breastmilk in postnatal life lies in the strong association between breastfeeding and the reduction in the risk of infection and infection-related infant mortality. However, data regarding the induction and dynamics of breastmilk antibodies following administration of the Pfizer-BioNTech BNT162b2 COVID-19 mRNA vaccine is scarce, as pregnant and lactating women were not included in the initial vaccine clinical trials. Here, we investigate the dynamics of the vaccine-specific antibody response in breastmilk and serum in a prospective cohort of ten lactating women who received two doses of the mRNA vaccine. We show that the antibody response is rapid and highly synchronized between breastmilk and serum, reaching stabilization 14 days after the second dose. The response in breastmilk includes both IgG and IgA with neutralization capacity. Maternal antibodies can reduce risk of infection of infants. Here, the authors show induction of IgG and IgA antibodies in breastmilk and serum of ten lactating women after immunization with the Pfizer-BioNTech BNT162b2 COVID-19 mRNA vaccine. Maternal antibodies can reduce risk of infection of infants. Here, the authors show induction of IgG and IgA antibodies in breastmilk and serum of ten lactating women after immunization with the Pfizer-BioNTech BNT162b2 COVID-19 mRNA vaccine. Abstract The importance of breastmilk in postnatal life lies in the strong association between breastfeeding and the reduction in the risk of infection and infection-related infant mortality. However, data regarding the induction and dynamics of breastmilk antibodies following administration of the Pfizer-BioNTech BNT162b2 COVID-19 mRNA vaccine is scarce, as pregnant and lactating women were not included in the initial vaccine clinical trials. Here, we investigate the dynamics of the vaccine-specific antibody response in breastmilk and serum in a prospective cohort of ten lactating women who received two doses of the mRNA vaccine. We show that the antibody response is rapid and highly synchronized between breastmilk and serum, reaching stabilization 14 days after the second dose. The response in breastmilk includes both IgG and IgA with neutralization capacity. The importance of breastmilk in postnatal life lies in the strong association between breastfeeding and the reduction in the risk of infection and infection-related infant mortality. However, data regarding the induction and dynamics of breastmilk antibodies following administration of the Pfizer-BioNTech BNT162b2 COVID-19 mRNA vaccine is scarce, as pregnant and lactating women were not included in the initial vaccine clinical trials. Here, we investigate the dynamics of the vaccine-specific antibody response in breastmilk and serum in a prospective cohort of ten lactating women who received two doses of the mRNA vaccine. We show that the antibody response is rapid and highly synchronized between breastmilk and serum, reaching stabilization 14 days after the second dose. The response in breastmilk includes both IgG and IgA with neutralization capacity.Maternal antibodies can reduce risk of infection of infants. Here, the authors show induction of IgG and IgA antibodies in breastmilk and serum of ten lactating women after immunization with the Pfizer-BioNTech BNT162b2 COVID-19 mRNA vaccine. |
ArticleNumber | 6222 |
Author | Rosenberg-Friedman, Michal Alter, Joel Dessau, Moshe Dror, Yael Yogev, Yariv Lubetzky, Ronit Many, Ariel Werbner, Michal Bahar, Yael Gal-Tanamy, Meital Wine, Yariv Kigel, Aya |
Author_xml | – sequence: 1 givenname: Michal surname: Rosenberg-Friedman fullname: Rosenberg-Friedman, Michal organization: Department of Obstetrics and Gynecology, Lis Maternity & Women’s Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University – sequence: 2 givenname: Aya surname: Kigel fullname: Kigel, Aya organization: The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University – sequence: 3 givenname: Yael surname: Bahar fullname: Bahar, Yael organization: The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University – sequence: 4 givenname: Michal surname: Werbner fullname: Werbner, Michal organization: Molecular Virology Lab, The Azrieli Faculty of Medicine, Bar-Ilan University – sequence: 5 givenname: Joel surname: Alter fullname: Alter, Joel organization: The Laboratory of Structural Biology of Infectious Diseases, The Azrieli Faculty of Medicine, Bar-Ilan University – sequence: 6 givenname: Yariv surname: Yogev fullname: Yogev, Yariv organization: Department of Obstetrics and Gynecology, Lis Maternity & Women’s Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University – sequence: 7 givenname: Yael surname: Dror fullname: Dror, Yael organization: The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University – sequence: 8 givenname: Ronit surname: Lubetzky fullname: Lubetzky, Ronit organization: Sackler Faculty of Medicine, Tel Aviv University, Department of Pediatrics, Dana Dwek Children’s Hospital, Tel Aviv Sourasky Medical Center – sequence: 9 givenname: Moshe orcidid: 0000-0002-1954-3625 surname: Dessau fullname: Dessau, Moshe organization: The Laboratory of Structural Biology of Infectious Diseases, The Azrieli Faculty of Medicine, Bar-Ilan University – sequence: 10 givenname: Meital surname: Gal-Tanamy fullname: Gal-Tanamy, Meital organization: Molecular Virology Lab, The Azrieli Faculty of Medicine, Bar-Ilan University – sequence: 11 givenname: Ariel surname: Many fullname: Many, Ariel organization: Department of Obstetrics and Gynecology, Lis Maternity & Women’s Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University – sequence: 12 givenname: Yariv orcidid: 0000-0001-5767-9059 surname: Wine fullname: Wine, Yariv email: yarivwine@tauex.tau.ac.il organization: The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University |
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Snippet | The importance of breastmilk in postnatal life lies in the strong association between breastfeeding and the reduction in the risk of infection and... Abstract The importance of breastmilk in postnatal life lies in the strong association between breastfeeding and the reduction in the risk of infection and... Maternal antibodies can reduce risk of infection of infants. Here, the authors show induction of IgG and IgA antibodies in breastmilk and serum of ten... |
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Title | BNT162b2 mRNA vaccine elicited antibody response in blood and milk of breastfeeding women |
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