Histo-blood group antigens of glycosphingolipids predict susceptibility of human intestinal enteroids to norovirus infection

• Published in: The Journal of biological chemistry Vol. 295; no. 47; pp. 15974 - 15987
• Main Authors: Rimkute, Inga, Thorsteinsson, Konrad, Henricsson, Marcus, Tenge, Victoria R., Yu, Xiaoming, Lin, Shih-Ching, Haga, Kei, Atmar, Robert L., Lycke, Nils, Nilsson, Jonas, Estes, Mary K., Bally, Marta, Larson, Göran
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.11.2020; American Society for Biochemistry and Molecular Biology
• Subjects: Biochemistry & Molecular Biology; Biochemistry and Molecular Biology; Biokemi och molekylärbiologi; Blood Group Antigens - metabolism; Caliciviridae Infections - metabolism; Caliciviridae Infections - pathology; cell-surface antigens; ceramide; characterization; epithelial-cells; expression; fetal tissue; fucosyltransferase; glycerophospholipid; Glycobiology and Extracellular Matrices; glycolipid structure; glycosphingolipid; Glycosphingolipids - metabolism; glycosylation; host-pathogen interaction; human norovirus; Humans; intestinal epithelium; Intestinal Mucosa - metabolism; Intestinal Mucosa - pathology; Intestinal Mucosa - virology; intestine; meconium; membrane-properties; mini-guts; molecular; Norovirus - metabolism; Organoids - metabolism; Organoids - pathology; Organoids - virology; plus-stranded RNA virus; replication; sphingolipid; sphingomyelin; stem-cells; viral; viral replication; Virus Attachment; virus entry; virus-like particles; host-pathogen interaction; intestine; sphingolipid; glycosphingolipid; glycosylation; fucosyltransferase; viral replication; ceramide; plus-stranded RNA virus; virus entry; glycerophospholipid; sphingomyelin; intestinal epithelium; glycolipid structure; human norovirus

The molecular mechanisms behind infection and propagation of human restricted pathogens such as human norovirus (HuNoV) have defied interrogation because they were previously unculturable. However, human intestinal enteroids (HIEs) have emerged to offer unique ex vivo models for targeted studies of...