Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing - Wu, Xueling; Zhou, Tongqing; Zhu, Jiang; Zhang, Baoshan; Georgiev, Ivelin; Wang, Charlene; Chen, Xuejun; Longo, Nancy S.; Louder, Mark; McKee, Krisha; O'Dell, Sijy; Perfetto, Stephen; et al. (Science (American Association for the Advancement of Science), 2011)
Keywords: 60 APPLIED LIFE SCIENCES; AIDS Vaccines; Alleles; Amino Acid Sequence; ANTIBODIES; Antibodies, Neutralizing - chemistry; Antibodies, Neutralizing - genetics; Antibodies, Neutralizing - immunology; Antibodies, Neutralizing - isolation & purification; Antibody Affinity; Antibody Specificity; B lymphocytes; Base Sequence; BASIC BIOLOGICAL SCIENCES; Binding Sites; Binding Sites, Antibody; Biological and medical sciences; CD4 antigen; CD4 Antigens - metabolism; CHAINS; Complementarity Determining Regions - genetics; CRYSTAL STRUCTURE; Crystalline structure; CRYSTALLOGRAPHY; Crystallography, X-Ray; Epitopes; evolution; Evolution, Molecular; FUNCTIONALS; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Genes, Immunoglobulin Heavy Chain; GENETICS; Genetics of the immune response; Genomics; Germ cells; High throughput nucleotide sequencing; HIV 1; HIV Antibodies - chemistry; HIV Antibodies - genetics; HIV Antibodies - immunology; HIV Antibodies - isolation & purification; HIV Envelope Protein gp120 - chemistry; HIV Envelope Protein gp120 - immunology; HIV Envelope Protein gp120 - metabolism; HIV infections; HIV Infections - immunology; HIV-1 - chemistry; HIV-1 - immunology; Human immunodeficiency virus 1; Humans; IMMUNITY; Immunobiology; Immunoglobulin Fab Fragments - chemistry; Immunoglobulin Fab Fragments - immunology; Immunoglobulin Heavy Chains - chemistry; Immunoglobulin Heavy Chains - immunology; Immunoglobulin J-Chains - genetics; Immunoglobulin Light Chains - chemistry; Immunoglobulin Light Chains - immunology; IMMUNOGLOBULINS; Models, Molecular; Molecular biophysics; Molecular Sequence Data; Mutation; neutralization; Neutralizing antibodies; Phylogenetics; Sequence Analysis, DNA; Structure in molecular biology; viral morphology; X-ray diffraction; Virus; Molecular evolution; Nucleotide sequence; Retroviridae; Human immunodeficiency virus; Gene expression; Lentivirus; Neutralizing antibody; Crystalline structure