Distinct immune cell dynamics correlate with the immunogenicity and reactogenicity of SARS-CoV-2 mRNA vaccine

• Published in: Cell reports. Medicine Vol. 3; no. 5; p. 100631
• Main Authors: Takano, Tomohiro, Morikawa, Miwa, Adachi, Yu, Kabasawa, Kiyomi, Sax, Nicolas, Moriyama, Saya, Sun, Lin, Isogawa, Masanori, Nishiyama, Ayae, Onodera, Taishi, Terahara, Kazutaka, Tonouchi, Keisuke, Nishimura, Masashi, Tomii, Kentaro, Yamashita, Kazuo, Matsumura, Takayuki, Shinkai, Masaharu, Takahashi, Yoshimasa
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 17.05.2022; Elsevier
• Subjects: Advanced Basic Science; adverse events; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; BNT162 Vaccine - adverse effects; BNT162 Vaccine - immunology; BNT162 Vaccine - therapeutic use; cell dynamics; COVID-19 - immunology; COVID-19 - prevention & control; COVID-19 Vaccines - adverse effects; COVID-19 Vaccines - immunology; COVID-19 Vaccines - therapeutic use; Humans; immune correlates; innate immunity; mRNA vaccine; mRNA Vaccines - adverse effects; mRNA Vaccines - immunology; mRNA Vaccines - therapeutic use; neutralizing antibodies; SARS-CoV-2; SARS-CoV-2 - genetics; Vaccines, Synthetic - adverse effects; Vaccines, Synthetic - immunology; Vaccines, Synthetic - therapeutic use; SARS-CoV-2; immune correlates; innate immunity; neutralizing antibodies; adverse events; mRNA vaccine; cell dynamics

Two doses of Pfizer/BioNTech BNT162b2 mRNA vaccine elicit robust severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing antibodies with frequent adverse events. Here, by applying a high-dimensional immune profiling on 92 vaccinees, we identify six vaccine-induced immune dynamics t...