Molecular circuits in thrombosis and inflammation

• Published in: Thrombosis and haemostasis Vol. 109; no. 3; p. 416
• Main Author: Esmon, Charles T
• Format: Journal Article
• Language: English
• Published: Germany 01.03.2013
• Subjects: Animals; Blood Coagulation; Blood Platelets - metabolism; Coagulants - metabolism; Complement System Proteins - metabolism; Cytokines - metabolism; DNA - metabolism; Histones - metabolism; Humans; Infection; Inflammation - metabolism; Mice; Nucleosomes - metabolism; Sepsis; Thrombin - metabolism; Thrombosis - metabolism; Time Factors; Toll-Like Receptors - metabolism

Inflammatory cytokines promote the activation of coagulation through the induction of tissue factor, downregulation of thrombomodulin and upregulation of plasminogen activator inhibitor. In addition to these mechanisms, infections can trigger the release of extracellular traps from leukocytes consis...