Possible Involvement of Serum and Synovial Fluid Resistin in Knee Osteoarthritis: Cartilage Damage, Clinical, and Radiological Links

• Published in: Journal of clinical laboratory analysis Vol. 30; no. 5; pp. 437 - 443
• Main Authors: Song, Yong-zhou, Guan, Jian, Wang, Hua-jun, Ma, Wei, Li, Feng, Xu, Fang, Ding, Luo-bin, Xie, Lei, Liu, Bo, Liu, Kai, Lv, Zhe
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.09.2016; John Wiley & Sons, Inc; John Wiley and Sons Inc
• Subjects: Aged; Analysis of Variance; Arthritis; Biomarkers; Cartilage; Cartilage Diseases - diagnostic imaging; Cartilage Diseases - etiology; Case-Control Studies; catilage damage; Cytokines; disease severity; Enzyme-Linked Immunosorbent Assay; Female; Humans; Knee; Male; Middle Aged; osteoarthritis; Osteoarthritis, Knee - blood; Osteoarthritis, Knee - complications; Osteoarthritis, Knee - diagnostic imaging; Osteoarthritis, Knee - pathology; resistin; Resistin - blood; Retrospective Studies; Severity of Illness Index; Statistics as Topic; Synovial Fluid - metabolism; resistin; catilage damage; disease severity; osteoarthritis
• ISSN: 0887-8013; 1098-2825
• DOI: 10.1002/jcla.21876

Background Resistin is an adipocytokine associated with inflammation and insulin resistance. Recent studies have shown that resistin plays an important role in the pathogenesis and progression in osteoarthritis (OA) patients. The current study was aimed at investigating the relationship between resistin in serum and synovial fluid (SF) and disease severity in patients with knee osteoarthritis. Method Seventy‐four patients diagnosed with knee OA and 79 healthy controls receiving regular body check in our hospital were recruited in the study. The Noyes score method was used to assess articular cartilage damage arthroscopically. The symptomatic severity was evaluated according to the Western Ontario McMaster University Osteoarthritis (WOMAC) scores. The radiographic disease severity of OA was assessed by the Kellgren‐Lawrence (K–L) grading system. The resistin levels in serum and SF were determined by enzyme‐linked immunosorbent assay. Cartilage degradation marker CTX–II in SF was also examined. Results SF but not serum resistin levels are positively associated with Noyes scores, K‐L grading scores WOMAC pain scores, physical functional scores and WOMAC total scores. In addition, SF resistin correlated positively with CTX‐II. Conclusion Resistin in SF might serve as a potential biomarker for reflecting the disease severity and cartilage degenerative extent of knee OA.