Predictive advantage of a cell type classification for pulmonary adenocarcinoma coupled with data for p53, K‐ras and EGFR alterations

• Published in: Cancer science Vol. 101; no. 7; pp. 1745 - 1753
• Main Authors: Okada, Akira, Shimmyo, Takuo, Hashimoto, Takehisa, Kobayashi, Yasuhito, Miyagi, Yohei, Ishikawa, Yuichi, Nakagawa, Ken, Hayashi, Junichi, Tsuchiya, Eiju
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2010; Blackwell
• Subjects: Adenocarcinoma - classification; Adenocarcinoma - genetics; Adenocarcinoma - pathology; Aged; Biological and medical sciences; ErbB Receptors - genetics; Female; Genes, p53; Genes, ras; Humans; Lung Neoplasms - classification; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Male; Medical sciences; Middle Aged; Original; Predictive Value of Tests; Reproducibility of Results; Tumor Suppressor Protein p53 - genetics; Tumors; World Health Organization; Adenocarcinoma; Lung; Malignant tumor; Respiratory system; Epidermal growth factor receptor; K ras Gene; Cancerology; TP53 Gene; C-Onc gene; Classification; Protooncogene; Cancer; Tumor suppressor gene

We analyzed relationships between histological subtypes of pulmonary adenocarcinomas and three gene alterations (p53, K‐ras, and epidermal growth factor receptor gene), or thyroid transcription factor‐1 (TTF‐1) expression, and also studied prognoses by the subtypes, with or without combined multiple...