Population pharmacokinetic modeling and simulation for assessing renal impairment effect on the pharmacokinetics of mirogabalin

• Published in: Journal of clinical pharmacology Vol. 56; no. 2; p. 203
• Main Authors: Yin, Ophelia Q P, Merante, Domenico, Truitt, Kenneth, Miller, Raymond
• Format: Journal Article
• Language: English
• Published: England 01.02.2016
• Subjects: Adult; Area Under Curve; Bridged Bicyclo Compounds - administration & dosage; Bridged Bicyclo Compounds - blood; Bridged Bicyclo Compounds - metabolism; Bridged Bicyclo Compounds - pharmacokinetics; Case-Control Studies; Computer Simulation; Female; Half-Life; Humans; Kidney Diseases - metabolism; Male; Middle Aged; Models, Biological; mirogabalin; population pharmacokinetics; renal impairment

A population pharmacokinetic model was developed to describe plasma concentrations of mirogabalin and lactam metabolite, obtained following a single oral dose of 5 mg mirogabalin to subjects with varying degrees of renal function.A 2-compartment model was used for both mirogabalin and lactam metabol...