Incorporation of multicellular spheroids into 3‐D polymeric scaffolds provides an improved tumor model for screening anticancer drugs

• Published in: Cancer science Vol. 101; no. 12; pp. 2637 - 2643
• Main Authors: Ho, Won Jin, Pham, Edward A., Kim, Jun W., Ng, Christopher W., Kim, Jae H., Kamei, Daniel T., Wu, Benjamin M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2010; Blackwell
• Subjects: Biological and medical sciences; Drug Screening Assays, Antitumor - methods; Humans; Medical sciences; Original; Spheroids, Cellular - cytology; Spheroids, Cellular - drug effects; Tissue Scaffolds; Tumor Cells, Cultured - cytology; Tumor Cells, Cultured - drug effects; Tumors; Antineoplastic agent; Drug; Incorporation; Cancerology; Tumor; Models; Spheroid; Medical screening

Development of cancer therapeutics requires a thorough evaluation of drug efficacy in vitro before animal testing and subsequent clinical trials. Three‐dimensional (3‐D) in vitro models have therefore been investigated for drug screening. In this study, we have developed a novel in vitro model in wh...