Change in retinal structural anatomy during the preclinical stage of Alzheimer's disease

• Published in: Alzheimer's & dementia : diagnosis, assessment & disease monitoring Vol. 10; no. 1; pp. 196 - 209
• Main Authors: Santos, Cláudia Y., Johnson, Lenworth N., Sinoff, Stuart E., Festa, Elena K., Heindel, William C., Snyder, Peter J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 2018; Elsevier; Wiley
• Subjects: Alzheimer's disease; Amyloid; Cognition; McGurk effect; OCT; Optical coherence tomography; Preclinical; Retinal; Retinal Imaging; RNFL; OCT; RNFL; Optical coherence tomography; Cognition; Amyloid; Preclinical; McGurk effect; Alzheimer's disease; Retinal

We conducted a 27-month longitudinal study of mid-life adults with preclinical Alzheimer's disease (AD), using spectral domain optical coherence tomography to compare changes in volume and thickness in all retinal neuronal layers to those of age-matched healthy control subjects. Fifty-six older...