Tumor Evolution and Intratumor Heterogeneity of an Oropharyngeal Squamous Cell Carcinoma Revealed by Whole-Genome Sequencing

• Published in: Neoplasia (New York, N.Y.) Vol. 15; no. 12; pp. 1371 - IN7
• Main Authors: Zhang, Xinyi Cindy, Xu, Chang, Mitchell, Ryan M, Zhang, Bo, Zhao, Derek, Li, Yao, Huang, Xin, Fan, Wenhong, Wang, Hongwei, Lerma, Luisa Angelica, Upton, Melissa P, Hay, Ashley, Méndez, Eduardo, Zhao, Lue Ping
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2013; Elsevier
• Subjects: Aged; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - secondary; DNA Mutational Analysis; Genes, Neoplasm; Genome, Human; High-Throughput Nucleotide Sequencing; Human papillomavirus; Humans; INDEL Mutation; Lymphatic Metastasis; Male; Molecular Sequence Annotation; Oncology; Open Reading Frames; Oropharyngeal Neoplasms - genetics; Oropharyngeal Neoplasms - pathology

Abstract Head and neck squamous cell carcinoma (HNSCC) is characterized by significant genomic instability that could lead to clonal diversity. Intratumor clonal heterogeneity has been proposed as a major attribute underlying tumor evolution, progression, and resistance to chemotherapy and radiation...