Deep mutational scanning of H5 hemagglutinin to inform influenza virus surveillance

• Published in: PLoS biology Vol. 22; no. 11; p. e3002916
• Main Authors: Dadonaite, Bernadeta, Ahn, Jenny J., Ort, Jordan T., Yu, Jin, Furey, Colleen, Dosey, Annie, Hannon, William W., Vincent Baker, Amy L., Webby, Richard J., King, Neil P., Liu, Yan, Hensley, Scott E., Peacock, Thomas P., Moncla, Louise H., Bloom, Jesse D.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.11.2024; Public Library of Science (PLoS)
• Subjects: Amino acids; Animals; Antibodies, Viral - blood; Antibodies, Viral - immunology; Epidemics; Female; Ferrets; Genetic aspects; Health aspects; Hemagglutinin Glycoproteins, Influenza Virus - genetics; Hemagglutinin Glycoproteins, Influenza Virus - immunology; Humans; Influenza; Influenza A virus - genetics; Influenza A virus - immunology; Influenza viruses; Influenza, Human - epidemiology; Influenza, Human - immunology; Influenza, Human - virology; Lectins; Mice; Mutation; Mutation (Biology); Orthomyxoviridae Infections - virology; United States; Vaccination; Viral proteins; United States

H5 influenza is considered a potential pandemic threat. Recently, H5 viruses belonging to clade 2.3.4.4b have caused large outbreaks in avian and multiple nonhuman mammalian species. Previous studies have identified molecular phenotypes of the viral hemagglutinin (HA) protein that contribute to pand...