Comparison of Inducibility of CYP1A and CYP3A mRNAs by Prototypical Inducers in Primary Cultures of Human, Cynomolgus Monkey, and Rat Hepatocytes
This study was conducted to investigate the effects of treatment with the prototypical inducers rifampicin (Rif), dexamethasone (Dex), and omeprazole (Ome) on the mRNA levels of drug-metabolizing enzymes in primary cultures of cryopreserved human, cynomolgus monkey, and rat hepatocytes. Analysis was...
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Published in | DRUG METABOLISM AND PHARMACOKINETICS Vol. 22; no. 3; pp. 178 - 186 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.01.2007
Japanese Society for the Study of Xenobiotics |
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Abstract | This study was conducted to investigate the effects of treatment with the prototypical inducers rifampicin (Rif), dexamethasone (Dex), and omeprazole (Ome) on the mRNA levels of drug-metabolizing enzymes in primary cultures of cryopreserved human, cynomolgus monkey, and rat hepatocytes. Analysis was performed by quantitative real-time RT-PCR using primers and TaqMan probes. Treatment with Ome substantially increased the mRNA levels of both CYP1A1 and CYP1A2 in human hepatocytes, but increased only the mRNA level of CYP1A1 in monkey hepatocytes, whereas it had no marked effect on the mRNA levels of CYP1A1 or CYP1A2 in rat hepatocytes. Treatment with Rif or Dex did not markedly affect the mRNA level of CYP1A in any of the hepatocyte cultures under the conditions used. All three inducers increased the mRNA level of CYP3A8 in monkey hepatocytes (in the order Rif>Dex>Ome), and a similar profile was observed for the mRNA level of CYP3A4 in human hepatocytes, but the potency of induction was markedly attenuated. In contrast, only Dex substantially increased the mRNA level of CYP3A1 in rat hepatocytes, with Rif and Ome showing no effects. These results indicate that the molecular mechanisms responsible for the regulation of CYP1A2 genes differ between humans and cynomolgus monkeys, although the regulatory mechanisms for CYP1A1 and CYP3A genes are similar. |
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AbstractList | This study was conducted to investigate the effects of treatment with the prototypical inducers rifampicin (Rif), dexamethasone(Dex), and omeprazole(Ome) on the mRNA levels of drugmetabolizing enzymes in primary cultures of cryopreserved human, cynomolgus monkey, and rat hepatocytes. Analysis was performed by quantitative real-time RT-PCR using primers and TaqMan probes. Treatment with Ome substantially in creased the mRNA levels of both CYP1A1 and CYP1A2 in human hepatocytes , but increased only the mRNA level of CYP1A1 in monkey hepatocytes, whereas it had no marked effect on the mRNA levels of CYP1A1 or CYP1A2 in rat hepatocytes. Treatment with Rif or Dex did not markedly affect the mRNA level of CYP1A in any of the hepatocyte cultures under the conditions used. All three inducers increased the mRNA level of CYP3A8 in monkey hepatocytes(in the order Rif>Dex≧Ome), and a similar profile was observed for the mRNA level of CYP3A4 in human hepatocytes, but the potency of induction was markedly attenuated. In contrast, only Dex substantially increased the mRNA level of CYP3A1 in rat hepatocytes, with Rif and Ome showing no effects. These results indicate that the molecular mechanisms responsible for the regulation of CYP1A2 genes differ between humans and cynomolgus monkeys, although the regulatory mechanisms for CYP1A1 and CYP3A genes are similar. This study was conducted to investigate the effects of treatment with the prototypical inducers rifampicin (Rif), dexamethasone (Dex), and omeprazole (Ome) on the mRNA levels of drug-metabolizing enzymes in primary cultures of cryopreserved human, cynomolgus monkey, and rat hepatocytes. Analysis was performed by quantitative real-time RT-PCR using primers and TaqMan probes. Treatment with Ome substantially increased the mRNA levels of both CYP1A1 and CYP1A2 in human hepatocytes, but increased only the mRNA level of CYP1A1 in monkey hepatocytes, whereas it had no marked effect on the mRNA levels of CYP1A1 or CYP1A2 in rat hepatocytes. Treatment with Rif or Dex did not markedly affect the mRNA level of CYP1A in any of the hepatocyte cultures under the conditions used. All three inducers increased the mRNA level of CYP3A8 in monkey hepatocytes (in the order Rif>Dex>Ome), and a similar profile was observed for the mRNA level of CYP3A4 in human hepatocytes, but the potency of induction was markedly attenuated. In contrast, only Dex substantially increased the mRNA level of CYP3A1 in rat hepatocytes, with Rif and Ome showing no effects. These results indicate that the molecular mechanisms responsible for the regulation of CYP1A2 genes differ between humans and cynomolgus monkeys, although the regulatory mechanisms for CYP1A1 and CYP3A genes are similar. This study was conducted to investigate the effects of treatment with the prototypical inducers rifampicin (Rif), dexamethasone (Dex), and omeprazole (Ome) on the mRNA levels of drug-metabolizing enzymes in primary cultures of cryopreserved human, cynomolgus monkey, and rat hepatocytes. Analysis was performed by quantitative real-time RT-PCR using primers and TaqMan probes. Treatment with Ome substantially increased the mRNA levels of both CYP1A1 and CYP1A2 in human hepatocytes, but increased only the mRNA level of CYP1A1 in monkey hepatocytes, whereas it had no marked effect on the mRNA levels of CYP1A1 or CYP1A2 in rat hepatocytes. Treatment with Rif or Dex did not markedly affect the mRNA level of CYP1A in any of the hepatocyte cultures under the conditions used. All three inducers increased the mRNA level of CYP3A8 in monkey hepatocytes (in the order Rif>Dex>or=Ome), and a similar profile was observed for the mRNA level of CYP3A4 in human hepatocytes, but the potency of induction was markedly attenuated. In contrast, only Dex substantially increased the mRNA level of CYP3A1 in rat hepatocytes, with Rif and Ome showing no effects. These results indicate that the molecular mechanisms responsible for the regulation of CYP1A2 genes differ between humans and cynomolgus monkeys, although the regulatory mechanisms for CYP1A1 and CYP3A genes are similar. |
Author | Shimizu, Takefumi Nakayama, Mitsuo Suzuki, Emako Satoh, Tetsuo Naito, Shinsaku Narimatsu, Shizuo Suganuma, Yasuyuki Nishimura, Masuhiro Koeda, Akiko |
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Cites_doi | 10.1016/0016-5085(90)90963-2 10.1080/004982599238489 10.1172/JCI3703 10.2133/dmpk.21.297 10.1016/0006-2952(94)90363-8 10.1074/jbc.272.50.31755 10.3109/10408449209145319 10.2133/dmpk.19.422 10.1248/bpb.26.1052 10.1016/j.bbrc.2006.06.012 10.1016/S0006-2952(99)00310-X 10.1248/bpb.28.886 10.1248/yakushi.123.369 10.1016/S0091-679X(08)61797-5 10.1248/yakushi.122.339 10.1046/j.0014-2956.2001.02540.x 10.2133/dmpk.20.46 10.1016/S0006-2952(98)00100-2 10.1124/mol.58.2.361 10.1126/science.7732381 10.1248/bpb.28.143 10.1016/S0009-2797(01)00163-6 10.1073/pnas.95.21.12208 10.1111/j.1432-1033.1996.0642p.x 10.1016/S0021-9258(17)37466-5 10.2133/dmpk.20.121 10.1016/S0304-4165(02)00481-6 10.1006/abbi.1993.1439 10.1124/pr.55.4.2 10.1080/00498250050077986 10.2133/dmpk.19.135 10.1191/0960327104ht453oa |
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References | Seglen (bb0040) 1976; 13 Pascussi, Drocourt, Fabre, Maurel, Vilarem (bb0160) 2000; 58 Pascussi, Drocourt, Gerbal-Chaloin, Fabre, Maurel, Vilarem (bb0165) 2001; 268 Quattrochi, Tukey (bb0125) 1993; 43 Backlund, Johansson, Mkrtchian, Ingel-man-Sundberg (bb0145) 1997; 272 Wrighton, Schuetz, Watkins, Maurel, Barwick, Bailey, Hartle, Young, Guzelian (bb0020) 1985; 28 Nishimura, Yaguti, Yoshitsugu, Naito, Satoh (bb0100) 2003; 123 Diaz, Fabre, Daujat, Aubert, Bories, Michel, Maurel (bb0025) 1990; 99 Wrighton, Stevens (bb0095) 1992; 22 Hewitt, Fischer, Zuehlke, Oesch, Utesch (bb0030) 2000; 30 Bertilsson, Heidrich, Svensson, Asman, Jendeberg, Sydow-Bäckman, Ohlsson, Postlind, Blomquist, Berkenstam (bb0155) 1998; 95 Moore, Moore, Maglich, Kliewer (bb0180) 2003; 1619 Sakuma, Hieda, Igarashi, Ohgiya, Nagata, Nemoto, Kamataki (bb0110) 1998; 56 Nishimura, Ueda, Naito (bb0090) 2003; 26 Hewitt, Utesch (bb0035) 2004; 23 Nishimura, Koeda, Suzuki, Kawano, Nakayama, Satoh, Narimatsu, Naito (bb0050) 2006; 21 Nishimura, Naito, Yokoi (bb0080) 2004; 19 Lehmann, McKee, Watson, Willson, Moore, Kliewer (bb0150) 1998; 102 Kocarek, Schuetz, Strom, Fisher, Guzelian (bb0010) 1995; 23 Shimada, Yamazaki, Mimura, Inui, Guengerich (bb0190) 1994; 270 Nishimura, Naito (bb0060) 2005; 28 Li, Rasmussen, Xu, Kaminski (bb0005) 1995; 274 Nishimura, Imai, Morioka, Kuribayashi, Kamataki, Naito (bb0070) 2004; 19 Handschin, Meyer (bb0170) 2003; 55 Quattrochi, Vu, Tukey (bb0135) 1994; 269 Nishimura, Yamaguchi, Yamauchi, Ueda, Naito (bb0085) 2005; 20 Nebert, Roe, Dieter, Solis, Yang, Dalton (bb0120) 2000; 59 Daujat, Charrasse, Fabre, Lesca, Jounaidi, Larroque, Poellinger, Maurel (bb0130) 1996; 237 Burke, Thompson, Weaver, Wolf, Mayer (bb0105) 1994; 48 Yamaguchi, Yamauchi, Nishimura, Ueda, Naito (bb0065) 2005; 28 Nishimura, Yoshitsugu, Naito, Hiraoka (bb0055) 2002; 122 Ohmori, Horie, Guengerich, Kiuchi, Kitada (bb0185) 1993; 305 Weaver, Dickins, Burke (bb0115) 1999; 29 Silva, Morin, Day, Kennedy, Payette, Rushmore, Yergey, Nicoll-Griffith (bb0015) 1998; 26 Fernandez-Salguero, Pineau, Hilbert, McPhail, Lee, Kimura, Nebert, Rudikoff, Ward, Gonzalez (bb0140) 1995; 268 Nishimura, Yokoi, Tateno, Kataoka, Takahashi, Horie, Yoshizato, Naito (bb0075) 2005; 20 LeCluyse (bb0175) 2001; 134 Nishimura, Koeda, Suzuki, Shimizu, Kawano, Nakayama, Satoh, Narimatsu, Naito (bb0045) 2006; 346 Moore (10.2133/dmpk.22.178_bb0180) 2003; 1619 Nishimura (10.2133/dmpk.22.178_bb0045) 2006; 346 Nishimura (10.2133/dmpk.22.178_bb0060) 2005; 28 Wrighton (10.2133/dmpk.22.178_bb0020) 1985; 28 Ohmori (10.2133/dmpk.22.178_bb0185) 1993; 305 Nishimura (10.2133/dmpk.22.178_bb0080) 2004; 19 Nebert (10.2133/dmpk.22.178_bb0120) 2000; 59 Shimada (10.2133/dmpk.22.178_bb0190) 1994; 270 Li (10.2133/dmpk.22.178_bb0005) 1995; 274 Kocarek (10.2133/dmpk.22.178_bb0010) 1995; 23 Fernandez-Salguero (10.2133/dmpk.22.178_bb0140) 1995; 268 Nishimura (10.2133/dmpk.22.178_bb0050) 2006; 21 Lehmann (10.2133/dmpk.22.178_bb0150) 1998; 102 Handschin (10.2133/dmpk.22.178_bb0170) 2003; 55 Nishimura (10.2133/dmpk.22.178_bb0075) 2005; 20 Wrighton (10.2133/dmpk.22.178_bb0095) 1992; 22 Pascussi (10.2133/dmpk.22.178_bb0165) 2001; 268 Hewitt (10.2133/dmpk.22.178_bb0035) 2004; 23 Seglen (10.2133/dmpk.22.178_bb0040) 1976; 13 Burke (10.2133/dmpk.22.178_bb0105) 1994; 48 Quattrochi (10.2133/dmpk.22.178_bb0125) 1993; 43 Bertilsson (10.2133/dmpk.22.178_bb0155) 1998; 95 Pascussi (10.2133/dmpk.22.178_bb0160) 2000; 58 Diaz (10.2133/dmpk.22.178_bb0025) 1990; 99 Nishimura (10.2133/dmpk.22.178_bb0090) 2003; 26 Sakuma (10.2133/dmpk.22.178_bb0110) 1998; 56 Nishimura (10.2133/dmpk.22.178_bb0100) 2003; 123 Nishimura (10.2133/dmpk.22.178_bb0085) 2005; 20 Weaver (10.2133/dmpk.22.178_bb0115) 1999; 29 Backlund (10.2133/dmpk.22.178_bb0145) 1997; 272 LeCluyse (10.2133/dmpk.22.178_bb0175) 2001; 134 Silva (10.2133/dmpk.22.178_bb0015) 1998; 26 Nishimura (10.2133/dmpk.22.178_bb0055) 2002; 122 Yamaguchi (10.2133/dmpk.22.178_bb0065) 2005; 28 Nishimura (10.2133/dmpk.22.178_bb0070) 2004; 19 Hewitt (10.2133/dmpk.22.178_bb0030) 2000; 30 Quattrochi (10.2133/dmpk.22.178_bb0135) 1994; 269 Daujat (10.2133/dmpk.22.178_bb0130) 1996; 237 |
References_xml | – volume: 346 start-page: 1033 year: 2006 end-page: 1039 ident: bb0045 article-title: Effects of prototypical drug-metabolizing enzyme inducers on mRNA expression of housekeeping genes in primary cultures of human and rat hepatocytes publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Naito – volume: 13 start-page: 29 year: 1976 end-page: 83 ident: bb0040 article-title: Preparation of isolated rat liver cells publication-title: Methods Cell Biol. contributor: fullname: Seglen – volume: 30 start-page: 665 year: 2000 end-page: 681 ident: bb0030 article-title: Metabolic activity of fresh and cryopreserved cynomolgus monkey (Macaca fascicularis) hepatocytes publication-title: Xenobiotica contributor: fullname: Utesch – volume: 268 start-page: 722 year: 1995 end-page: 726 ident: bb0140 article-title: Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor publication-title: Science contributor: fullname: Gonzalez – volume: 122 start-page: 339 year: 2002 end-page: 361 ident: bb0055 article-title: Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR publication-title: Yakugaku Zasshi contributor: fullname: Hiraoka – volume: 123 start-page: 369 year: 2003 end-page: 375 ident: bb0100 article-title: Tissue distribution of mRNA expression of human cytochrome P450 isoforms assessed by high-sensitivity real-time reverse transcription PCR publication-title: Yakugaku Zasshi contributor: fullname: Satoh – volume: 59 start-page: 65 year: 2000 end-page: 85 ident: bb0120 article-title: Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis publication-title: Biochem. Pharmacol. contributor: fullname: Dalton – volume: 102 start-page: 1016 year: 1998 end-page: 1023 ident: bb0150 article-title: The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions publication-title: J. Clin. Invest. contributor: fullname: Kliewer – volume: 21 start-page: 297 year: 2006 end-page: 307 ident: bb0050 article-title: Regulation of mRNA expression of MDR1, MRP1, MRP2 and MRP3 by prototypical microsomal enzyme inducers in primary cultures of human and rat hepatocytes publication-title: Drug Metab. Pharmacokinet. contributor: fullname: Naito – volume: 1619 start-page: 235 year: 2003 end-page: 238 ident: bb0180 article-title: Functional and structural comparison of PXR and CAR publication-title: Biochim. Biophys. Acta. contributor: fullname: Kliewer – volume: 19 start-page: 422 year: 2004 end-page: 429 ident: bb0070 article-title: Effects of NO-1886 (Ibrolipim), a lipoprotein lipase-promoting agent, on gene induction of cytochrome P450s, carboxylesterases, and sulfotransferases in primary cultures of human hepatocytes publication-title: Drug Metab. Pharmacokinet. contributor: fullname: Naito – volume: 19 start-page: 135 year: 2004 end-page: 149 ident: bb0080 article-title: Tissue-specific mRNA expression profiles of human nuclear receptor subfamilies publication-title: Drug Metab. Pharmacokinet. contributor: fullname: Yokoi – volume: 48 start-page: 923 year: 1994 end-page: 936 ident: bb0105 article-title: Cytochrome P450 specificities of alkoxyresorufin publication-title: Biochem. Pharmacol. contributor: fullname: Mayer – volume: 268 start-page: 6346 year: 2001 end-page: 6357 ident: bb0165 article-title: Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes: Sequential role of glucocorticoid receptor and pregnane X receptor publication-title: Eur. J. Biochem. contributor: fullname: Vilarem – volume: 56 start-page: 131 year: 1998 end-page: 139 ident: bb0110 article-title: Molecular cloning and functional analysis of cynomolgus monkey CYP1A2 publication-title: Biochem. Pharmacol. contributor: fullname: Kamataki – volume: 55 start-page: 649 year: 2003 end-page: 673 ident: bb0170 article-title: Induction of drug metabolism: the role of nuclear receptors publication-title: Pharmacol. Rev. contributor: fullname: Meyer – volume: 29 start-page: 467 year: 1999 end-page: 482 ident: bb0115 article-title: A comparison of basal and induced hepatic microsomal cytochrome P450 monooxygenase activities in the cynomolgus monkey (Macaca fascicularis) and man publication-title: Xenobiotica contributor: fullname: Burke – volume: 58 start-page: 361 year: 2000 end-page: 372 ident: bb0160 article-title: Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: Synergistic increase of CYP3A4 induction by pregnane X receptor activators publication-title: Mol. Pharmacol. contributor: fullname: Vilarem – volume: 22 start-page: 1 year: 1992 end-page: 21 ident: bb0095 article-title: The human hepatic cytochromes P450 involved in drug metabolism publication-title: Crit. Rev. Toxicol. contributor: fullname: Stevens – volume: 274 start-page: 673 year: 1995 end-page: 677 ident: bb0005 article-title: Rifampicin induction of lidocaine metabolism in cultured human hepatocytes publication-title: J. Pharmacol. Exp. Ther. contributor: fullname: Kaminski – volume: 26 start-page: 490 year: 1998 end-page: 496 ident: bb0015 article-title: Refinement of an publication-title: Drug Metab. Dispos. contributor: fullname: Nicoll-Griffith – volume: 28 start-page: 143 year: 2005 end-page: 147 ident: bb0065 article-title: Soybean oil fat emulsion prevents cytochrome P450 mRNA down-regulation induced by fat-free overdose total parenteral nutrition in infant rats publication-title: Biol. Pharm. Bull. contributor: fullname: Naito – volume: 99 start-page: 737 year: 1990 end-page: 747 ident: bb0025 article-title: Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450 publication-title: Gastroenterology contributor: fullname: Maurel – volume: 134 start-page: 283 year: 2001 end-page: 289 ident: bb0175 article-title: Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics publication-title: Chem. Biol. Interact. contributor: fullname: LeCluyse – volume: 20 start-page: 121 year: 2005 end-page: 126 ident: bb0075 article-title: Induction of human CYP1A2 and CYP3A4 in primary culture of hepatocytes from chimeric mice with humanized liver publication-title: Drug Metab. Pharmacokinet. contributor: fullname: Naito – volume: 237 start-page: 642 year: 1996 end-page: 652 ident: bb0130 article-title: Induction of CYP1A1 gene by benzimidazole derivatives during Caco-2 cell differentiation: Evidence for an aryl-hydrocarbon receptor-mediated mechanism publication-title: Eur. J. Biochem. contributor: fullname: Maurel – volume: 23 start-page: 307 year: 2004 end-page: 316 ident: bb0035 article-title: Cryopreserved rat, dog and monkey hepatocytes: Measurement of drug metabolizing enzymes in suspensions and cultures publication-title: Hum. Exp. Toxicol. contributor: fullname: Utesch – volume: 20 start-page: 46 year: 2005 end-page: 54 ident: bb0085 article-title: Role of soybean oil fat emulsion in the prevention of hepatic xenobiotic transporter mRNA up- and down-regulation induced by overdose of fat-free total parenteral nutrition in infant rats publication-title: Drug Metab. Pharmacokinet. contributor: fullname: Naito – volume: 305 start-page: 405 year: 1993 end-page: 413 ident: bb0185 article-title: Purification and characterization of two forms of hepatic microsomal cytochrome P450 from untreated cynomolgus monkeys publication-title: Arch. Biochem. Biophys. contributor: fullname: Kitada – volume: 269 start-page: 6949 year: 1994 end-page: 6954 ident: bb0135 article-title: The human CYP1A2 gene and induction by 3-methylcholanthrene: A region of DNA that supports AH-receptor binding and promoter-specific induction publication-title: J. Biol. Chem. contributor: fullname: Tukey – volume: 28 start-page: 886 year: 2005 end-page: 892 ident: bb0060 article-title: Tissue-specific mRNA expression profiles of human toll-like receptors and related genes publication-title: Biol. Pharm. Bull. contributor: fullname: Naito – volume: 43 start-page: 504 year: 1993 end-page: 508 ident: bb0125 article-title: Nuclear uptake of the Ah (dioxin) receptor in response to omeprazole: Transcriptional activation of the human CYP1A1 gene publication-title: Mol. Pharmacol. contributor: fullname: Tukey – volume: 270 start-page: 414 year: 1994 end-page: 423 ident: bb0190 article-title: Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians publication-title: J. Pharmacol. Exp. Ther. contributor: fullname: Guengerich – volume: 23 start-page: 415 year: 1995 end-page: 421 ident: bb0010 article-title: Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes publication-title: Drug Metab. Dispos. contributor: fullname: Guzelian – volume: 26 start-page: 1052 year: 2003 end-page: 1056 ident: bb0090 article-title: Effects of dimethyl sulfoxide on the gene induction of cytochrome P450 isoforms, UGT-dependent glucuronosyl transferase isoforms, and ABCB1 in primary culture of human hepatocytes publication-title: Biol. Pharm. Bull. contributor: fullname: Naito – volume: 272 start-page: 31755 year: 1997 end-page: 31763 ident: bb0145 article-title: Signal transduction-mediated activation of the aryl hydrocarbon receptor in rat hepatoma H4IIE cells publication-title: J. Biol. Chem. contributor: fullname: Ingel-man-Sundberg – volume: 28 start-page: 312 year: 1985 end-page: 321 ident: bb0020 article-title: Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat publication-title: Mol. Pharmacol. contributor: fullname: Guzelian – volume: 95 start-page: 12208 year: 1998 end-page: 12213 ident: bb0155 article-title: Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Berkenstam – volume: 99 start-page: 737 year: 1990 ident: 10.2133/dmpk.22.178_bb0025 article-title: Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450 publication-title: Gastroenterology doi: 10.1016/0016-5085(90)90963-2 contributor: fullname: Diaz – volume: 29 start-page: 467 year: 1999 ident: 10.2133/dmpk.22.178_bb0115 article-title: A comparison of basal and induced hepatic microsomal cytochrome P450 monooxygenase activities in the cynomolgus monkey (Macaca fascicularis) and man publication-title: Xenobiotica doi: 10.1080/004982599238489 contributor: fullname: Weaver – volume: 102 start-page: 1016 year: 1998 ident: 10.2133/dmpk.22.178_bb0150 article-title: The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions publication-title: J. Clin. Invest. doi: 10.1172/JCI3703 contributor: fullname: Lehmann – volume: 21 start-page: 297 year: 2006 ident: 10.2133/dmpk.22.178_bb0050 article-title: Regulation of mRNA expression of MDR1, MRP1, MRP2 and MRP3 by prototypical microsomal enzyme inducers in primary cultures of human and rat hepatocytes publication-title: Drug Metab. Pharmacokinet. doi: 10.2133/dmpk.21.297 contributor: fullname: Nishimura – volume: 48 start-page: 923 year: 1994 ident: 10.2133/dmpk.22.178_bb0105 article-title: Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver publication-title: Biochem. Pharmacol. doi: 10.1016/0006-2952(94)90363-8 contributor: fullname: Burke – volume: 272 start-page: 31755 year: 1997 ident: 10.2133/dmpk.22.178_bb0145 article-title: Signal transduction-mediated activation of the aryl hydrocarbon receptor in rat hepatoma H4IIE cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.50.31755 contributor: fullname: Backlund – volume: 22 start-page: 1 year: 1992 ident: 10.2133/dmpk.22.178_bb0095 article-title: The human hepatic cytochromes P450 involved in drug metabolism publication-title: Crit. Rev. Toxicol. doi: 10.3109/10408449209145319 contributor: fullname: Wrighton – volume: 19 start-page: 422 year: 2004 ident: 10.2133/dmpk.22.178_bb0070 article-title: Effects of NO-1886 (Ibrolipim), a lipoprotein lipase-promoting agent, on gene induction of cytochrome P450s, carboxylesterases, and sulfotransferases in primary cultures of human hepatocytes publication-title: Drug Metab. Pharmacokinet. doi: 10.2133/dmpk.19.422 contributor: fullname: Nishimura – volume: 26 start-page: 1052 year: 2003 ident: 10.2133/dmpk.22.178_bb0090 article-title: Effects of dimethyl sulfoxide on the gene induction of cytochrome P450 isoforms, UGT-dependent glucuronosyl transferase isoforms, and ABCB1 in primary culture of human hepatocytes publication-title: Biol. Pharm. Bull. doi: 10.1248/bpb.26.1052 contributor: fullname: Nishimura – volume: 346 start-page: 1033 year: 2006 ident: 10.2133/dmpk.22.178_bb0045 article-title: Effects of prototypical drug-metabolizing enzyme inducers on mRNA expression of housekeeping genes in primary cultures of human and rat hepatocytes publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2006.06.012 contributor: fullname: Nishimura – volume: 59 start-page: 65 year: 2000 ident: 10.2133/dmpk.22.178_bb0120 article-title: Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis publication-title: Biochem. Pharmacol. doi: 10.1016/S0006-2952(99)00310-X contributor: fullname: Nebert – volume: 43 start-page: 504 year: 1993 ident: 10.2133/dmpk.22.178_bb0125 article-title: Nuclear uptake of the Ah (dioxin) receptor in response to omeprazole: Transcriptional activation of the human CYP1A1 gene publication-title: Mol. Pharmacol. contributor: fullname: Quattrochi – volume: 28 start-page: 886 year: 2005 ident: 10.2133/dmpk.22.178_bb0060 article-title: Tissue-specific mRNA expression profiles of human toll-like receptors and related genes publication-title: Biol. Pharm. Bull. doi: 10.1248/bpb.28.886 contributor: fullname: Nishimura – volume: 123 start-page: 369 year: 2003 ident: 10.2133/dmpk.22.178_bb0100 article-title: Tissue distribution of mRNA expression of human cytochrome P450 isoforms assessed by high-sensitivity real-time reverse transcription PCR publication-title: Yakugaku Zasshi doi: 10.1248/yakushi.123.369 contributor: fullname: Nishimura – volume: 13 start-page: 29 year: 1976 ident: 10.2133/dmpk.22.178_bb0040 article-title: Preparation of isolated rat liver cells publication-title: Methods Cell Biol. doi: 10.1016/S0091-679X(08)61797-5 contributor: fullname: Seglen – volume: 122 start-page: 339 year: 2002 ident: 10.2133/dmpk.22.178_bb0055 article-title: Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR publication-title: Yakugaku Zasshi doi: 10.1248/yakushi.122.339 contributor: fullname: Nishimura – volume: 268 start-page: 6346 year: 2001 ident: 10.2133/dmpk.22.178_bb0165 article-title: Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes: Sequential role of glucocorticoid receptor and pregnane X receptor publication-title: Eur. J. Biochem. doi: 10.1046/j.0014-2956.2001.02540.x contributor: fullname: Pascussi – volume: 20 start-page: 46 year: 2005 ident: 10.2133/dmpk.22.178_bb0085 article-title: Role of soybean oil fat emulsion in the prevention of hepatic xenobiotic transporter mRNA up- and down-regulation induced by overdose of fat-free total parenteral nutrition in infant rats publication-title: Drug Metab. Pharmacokinet. doi: 10.2133/dmpk.20.46 contributor: fullname: Nishimura – volume: 56 start-page: 131 year: 1998 ident: 10.2133/dmpk.22.178_bb0110 article-title: Molecular cloning and functional analysis of cynomolgus monkey CYP1A2 publication-title: Biochem. Pharmacol. doi: 10.1016/S0006-2952(98)00100-2 contributor: fullname: Sakuma – volume: 28 start-page: 312 year: 1985 ident: 10.2133/dmpk.22.178_bb0020 article-title: Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat publication-title: Mol. Pharmacol. contributor: fullname: Wrighton – volume: 58 start-page: 361 year: 2000 ident: 10.2133/dmpk.22.178_bb0160 article-title: Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: Synergistic increase of CYP3A4 induction by pregnane X receptor activators publication-title: Mol. Pharmacol. doi: 10.1124/mol.58.2.361 contributor: fullname: Pascussi – volume: 268 start-page: 722 year: 1995 ident: 10.2133/dmpk.22.178_bb0140 article-title: Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor publication-title: Science doi: 10.1126/science.7732381 contributor: fullname: Fernandez-Salguero – volume: 270 start-page: 414 year: 1994 ident: 10.2133/dmpk.22.178_bb0190 article-title: Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians publication-title: J. Pharmacol. Exp. Ther. contributor: fullname: Shimada – volume: 28 start-page: 143 year: 2005 ident: 10.2133/dmpk.22.178_bb0065 article-title: Soybean oil fat emulsion prevents cytochrome P450 mRNA down-regulation induced by fat-free overdose total parenteral nutrition in infant rats publication-title: Biol. Pharm. Bull. doi: 10.1248/bpb.28.143 contributor: fullname: Yamaguchi – volume: 26 start-page: 490 year: 1998 ident: 10.2133/dmpk.22.178_bb0015 article-title: Refinement of an in vitro cell model for cytochrome P450 induction publication-title: Drug Metab. Dispos. contributor: fullname: Silva – volume: 134 start-page: 283 year: 2001 ident: 10.2133/dmpk.22.178_bb0175 article-title: Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics publication-title: Chem. Biol. Interact. doi: 10.1016/S0009-2797(01)00163-6 contributor: fullname: LeCluyse – volume: 95 start-page: 12208 year: 1998 ident: 10.2133/dmpk.22.178_bb0155 article-title: Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.95.21.12208 contributor: fullname: Bertilsson – volume: 237 start-page: 642 year: 1996 ident: 10.2133/dmpk.22.178_bb0130 article-title: Induction of CYP1A1 gene by benzimidazole derivatives during Caco-2 cell differentiation: Evidence for an aryl-hydrocarbon receptor-mediated mechanism publication-title: Eur. J. Biochem. doi: 10.1111/j.1432-1033.1996.0642p.x contributor: fullname: Daujat – volume: 269 start-page: 6949 year: 1994 ident: 10.2133/dmpk.22.178_bb0135 article-title: The human CYP1A2 gene and induction by 3-methylcholanthrene: A region of DNA that supports AH-receptor binding and promoter-specific induction publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)37466-5 contributor: fullname: Quattrochi – volume: 20 start-page: 121 year: 2005 ident: 10.2133/dmpk.22.178_bb0075 article-title: Induction of human CYP1A2 and CYP3A4 in primary culture of hepatocytes from chimeric mice with humanized liver publication-title: Drug Metab. Pharmacokinet. doi: 10.2133/dmpk.20.121 contributor: fullname: Nishimura – volume: 1619 start-page: 235 year: 2003 ident: 10.2133/dmpk.22.178_bb0180 article-title: Functional and structural comparison of PXR and CAR publication-title: Biochim. Biophys. Acta. doi: 10.1016/S0304-4165(02)00481-6 contributor: fullname: Moore – volume: 305 start-page: 405 year: 1993 ident: 10.2133/dmpk.22.178_bb0185 article-title: Purification and characterization of two forms of hepatic microsomal cytochrome P450 from untreated cynomolgus monkeys publication-title: Arch. Biochem. Biophys. doi: 10.1006/abbi.1993.1439 contributor: fullname: Ohmori – volume: 55 start-page: 649 year: 2003 ident: 10.2133/dmpk.22.178_bb0170 article-title: Induction of drug metabolism: the role of nuclear receptors publication-title: Pharmacol. Rev. doi: 10.1124/pr.55.4.2 contributor: fullname: Handschin – volume: 30 start-page: 665 year: 2000 ident: 10.2133/dmpk.22.178_bb0030 article-title: Metabolic activity of fresh and cryopreserved cynomolgus monkey (Macaca fascicularis) hepatocytes publication-title: Xenobiotica doi: 10.1080/00498250050077986 contributor: fullname: Hewitt – volume: 23 start-page: 415 year: 1995 ident: 10.2133/dmpk.22.178_bb0010 article-title: Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes publication-title: Drug Metab. Dispos. contributor: fullname: Kocarek – volume: 19 start-page: 135 year: 2004 ident: 10.2133/dmpk.22.178_bb0080 article-title: Tissue-specific mRNA expression profiles of human nuclear receptor subfamilies publication-title: Drug Metab. Pharmacokinet. doi: 10.2133/dmpk.19.135 contributor: fullname: Nishimura – volume: 23 start-page: 307 year: 2004 ident: 10.2133/dmpk.22.178_bb0035 article-title: Cryopreserved rat, dog and monkey hepatocytes: Measurement of drug metabolizing enzymes in suspensions and cultures publication-title: Hum. Exp. Toxicol. doi: 10.1191/0960327104ht453oa contributor: fullname: Hewitt – volume: 274 start-page: 673 year: 1995 ident: 10.2133/dmpk.22.178_bb0005 article-title: Rifampicin induction of lidocaine metabolism in cultured human hepatocytes publication-title: J. Pharmacol. Exp. Ther. contributor: fullname: Li |
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Snippet | This study was conducted to investigate the effects of treatment with the prototypical inducers rifampicin (Rif), dexamethasone (Dex), and omeprazole (Ome) on... This study was conducted to investigate the effects of treatment with the prototypical inducers rifampicin (Rif), dexamethasone(Dex), and omeprazole(Ome) on... |
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SubjectTerms | Adult Aged Animals Aryl Hydrocarbon Hydroxylases - genetics Cells, Cultured Child, Preschool cynomolgus monkey Cytochrome P-450 CYP1A1 - genetics Cytochrome P-450 CYP1A2 - genetics Cytochrome P-450 CYP3A - genetics Cytochrome P-450 Enzyme System - genetics cytochrome P450 Dexamethasone - pharmacology Female Gene Expression Regulation, Enzymologic hepatocytes Hepatocytes - cytology Hepatocytes - drug effects Hepatocytes - metabolism human Humans induction Macaca fascicularis Male Omeprazole - pharmacology rat Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction Rifampin - pharmacology RNA, Messenger - genetics RNA, Messenger - metabolism |
Title | Comparison of Inducibility of CYP1A and CYP3A mRNAs by Prototypical Inducers in Primary Cultures of Human, Cynomolgus Monkey, and Rat Hepatocytes |
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