Effect of micro- and macroporosity of bone substitutes on their mechanical properties and cellular response
The control of porosity morphology and physico-chemical characteristics of calcium phosphate bone substitutes is a key-point to guaranty healing success. In this work, micro- and macroporosity of materials processed with 70% Hydroxyapatite (HAP) and 30% beta-tricalcium phosphate (beta-TCP) were cont...
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| Published in | Journal of materials science. Materials in medicine Vol. 14; no. 12; pp. 1089 - 1097 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Springer Nature B.V
01.12.2003
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The control of porosity morphology and physico-chemical characteristics of calcium phosphate bone substitutes is a key-point to guaranty healing success. In this work, micro- and macroporosity of materials processed with 70% Hydroxyapatite (HAP) and 30% beta-tricalcium phosphate (beta-TCP) were controlled by sintering temperature and porogen addition, respectively. Porosity was quantified by scanning electron microscopy (pore size) and mercury intrusion porosimetry (interconnection between pores). The content of macrointerconnections and their size were dependent on porogen content, shape, and size. Mechanical properties (compressive strength) were strongly dependent on macroporosity size and content, on the basis of exponential laws, whereas microporosity ratio was less influent. Relying on those results, three types of materials with contrasting porous morphologies were processed and assessed in vitro, in primary culture of human osteoblasts and fibroblasts. With both types of cells, an exponential cellular growth was effective. Cells colonized the surface of the materials, bridging macroporosity, before colonizing the depth of the materials. Cell migration across and into macroporosity occurred via the emission by the cells of long cytoplasmic extensions that hanged on microporosity. Both macroporosity and macrointerconnectivity size influenced the penetration of cells. An interconnection size of 15 microm appeared to be effective to support this invasion without bringing down mechanical strength. |
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| AbstractList | The control of porosity morphology and physico-chemical characteristics of calcium phosphate bone substitutes is a key-point to guaranty healing success. In this work, micro- and macroporosity of materials processed with 70% Hydroxyapatite (HAP) and 30% *b-tricalcium phosphate (*b-TCP) were controlled by sintering temperature and porogen addition, respectively. Porosity was quantified by scanning electron microscopy (pore size) and mercury intrusion porosimetry (interconnection between pores). The content of macrointerconnections and their size were dependent on porogen content, shape, and size. Mechanical properties (compressive strength) were strongly dependent on macroporosity size and content, on the basis of exponential laws, whereas microporosity ratio was less influent. Relying on those results, three types of materials with contrasting porous morphologies were processed and assessed in vitro, in primary culture of human osteoblasts and fibroblasts. With both types of cells, an exponential cellular growth was effective. Cells colonized the surface of the materials, bridging macroporosity, before colonizing the depth of the materials. Cell migration across and into macroporosity occurred via the emission by the cells of long cytoplasmic extensions that hanged on microporosity. Both macroporosity and macrointerconnectivity size influenced the penetration of cells. An interconnection size of 15 *mm appeared to be effective to support this invasion without bringing down mechanical strength. The control of porosity morphology and physico-chemical characteristics of calcium phosphate bone substitutes is a key-point to guaranty healing success. In this work, micro- and macroporosity of materials processed with 70% Hydroxyapatite (HAP) and 30% beta -tricalcium phosphate ( beta -TCP) were controlled by sintering temperature and porogen addition, respectively. Porosity was quantified by scanning electron microscopy (pore size) and mercury intrusion porosimetry (interconnection between pores). The content of macrointerconnections and their size were dependent on porogen content, shape, and size. Mechanical properties (compressive strength) were strongly dependent on macroporosity size and content, on the basis of exponential laws, whereas microporosity ratio was less influent. Relying on those results, three types of materials with contrasting porous morphologies were processed and assessed in vitro, in primary culture of human osteoblasts and fibroblasts. With both types of cells, an exponential cellular growth was effective. Cells colonized the surface of the materials, bridging macroporosity, before colonizing the depth of the materials. Cell migration across and into macroporosity occurred via the emission by the cells of long cytoplasmic extensions that hanged on microporosity. Both macroporosity and macrointerconnectivity size influenced the penetration of cells. An interconnection size of 15 mu m appeared to be effective to support this invasion without bringing down mechanical strength. The control of porosity morphology and physico-chemical characteristics of calcium phosphate bone substitutes is a key-point to guaranty healing success. In this work, micro- and macroporosity of materials processed with 70% Hydroxyapatite (HAP) and 30% b-tricalcium phosphate (b-TCP) were controlled by sintering temperature and porogen addition, respectively. Porosity was quantified by scanning electron microscopy (pore size) and mercury intrusion porosimetry (interconnection between pores). The content of macrointerconnections and their size were dependent on porogen content, shape, and size. Mechanical properties (compressive strength) were strongly dependent on macroporosity size and content, on the basis of exponential laws, whereas microporosity ratio was less influent. Relying on those results, three types of materials with contrasting porous morphologies were processed and assessed in vitro, in primary culture of human osteoblasts and fibroblasts. With both types of cells, an exponential cellular growth was effective. Cells colonized the surface of the materials, bridging macroporosity, before colonizing the depth of the materials. Cell migration across and into macroporosity occurred via the emission by the cells of long cytoplasmic extensions that hanged on microporosity. Both macroporosity and macrointerconnectivity size influenced the penetration of cells. An interconnection size of 15 km appeared to be effective to support this invasion without bringing down mechanical strength. The control of porosity morphology and physico-chemical characteristics of calcium phosphate bone substitutes is a key-point to guaranty healing success. In this work, micro- and macroporosity of materials processed with 70% Hydroxyapatite (HAP) and 30% beta-tricalcium phosphate (beta-TCP) were controlled by sintering temperature and porogen addition, respectively. Porosity was quantified by scanning electron microscopy (pore size) and mercury intrusion porosimetry (interconnection between pores). The content of macrointerconnections and their size were dependent on porogen content, shape, and size. Mechanical properties (compressive strength) were strongly dependent on macroporosity size and content, on the basis of exponential laws, whereas microporosity ratio was less influent. Relying on those results, three types of materials with contrasting porous morphologies were processed and assessed in vitro, in primary culture of human osteoblasts and fibroblasts. With both types of cells, an exponential cellular growth was effective. Cells colonized the surface of the materials, bridging macroporosity, before colonizing the depth of the materials. Cell migration across and into macroporosity occurred via the emission by the cells of long cytoplasmic extensions that hanged on microporosity. Both macroporosity and macrointerconnectivity size influenced the penetration of cells. An interconnection size of 15 microm appeared to be effective to support this invasion without bringing down mechanical strength. The control of porosity morphology and physico-chemical characteristics of calcium phosphate bone substitutes is a key-point to guaranty healing success. In this work, micro- and macroporosity of materials processed with 70% Hydroxyapatite (HAP) and 30% β-tricalcium phosphate (β-TCP) were controlled by sintering temperature and porogen addition, respectively. Porosity was quantified by scanning electron microscopy (pore size) and mercury intrusion porosimetry (interconnection between pores). The content of macrointerconnections and their size were dependent on porogen content, shape, and size. Mechanical properties (compressive strength) were strongly dependent on macroporosity size and content, on the basis of exponential laws, whereas microporosity ratio was less influent. Relying on those results, three types of materials with contrasting porous morphologies were processed and assessed in vitro, in primary culture of human osteoblasts and fibroblasts. With both types of cells, an exponential cellular growth was effective. Cells colonized the surface of the materials, bridging macroporosity, before colonizing the depth of the materials. Cell migration across and into macroporosity occurred via the emission by the cells of long cytoplasmic extensions that hanged on microporosity. Both macroporosity and macrointerconnectivity size influenced the penetration of cells. An interconnection size of 15 μm appeared to be effective to support this invasion without bringing down mechanical strength.[PUBLICATION ABSTRACT] Micro- and macroporosity of materials processed with 70% hydroxyapatite and 30% beta-tricalcium phosphate were controlled by sintering temperature and porogen addition, respectively. Pore size was quantified by SEM and interconnection between pores by mercury intrusion porosimetry. The content of macrointerconnections and their size were dependent on porogen content, shape, and size. Mechanical properties (compressive strength) were strongly dependent on macroporosity size and content on the basis of exponential laws, whereas microporosity ratio was less influential. Relying on those results, three types of material with contrasting porous morphologies were processed and assessed, in vitro, in primary culture of human osteoblasts and fibroblasts. With both types of cell, an exponential cellular growth was effective. Cells colonised the surface of the materials, bridging macroporosity, before colonising the depth of the materials. Cell migration across and into macroporosity occurred via the emission by the cells of long cytoplasmic extensions that hung on microporosity. Both macroporosity and macrointerconnectivity size influenced the penetration of cells. An interconnection size of 15 micron appeared to be effective to support this penetration without reducing mechanical strength. 20 refs. |
| Author | Hartmann, D Bignon, A Melin, M Chouteau, J Carret, J-P Chevalier, J Fantozzi, G Chavassieux, P Boivin, G |
| Author_xml | – sequence: 1 givenname: A surname: Bignon fullname: Bignon, A organization: Institut National des Sciences appliquées, Groupe d'Etude de Métallurgie Physique et de Physique des Matériaux, CNRS Unité 5510, bat. Blaise Pascal, 20 av. Albert Einstein, 69621 Villeurbanne, France – sequence: 2 givenname: J surname: Chouteau fullname: Chouteau, J – sequence: 3 givenname: J surname: Chevalier fullname: Chevalier, J – sequence: 4 givenname: G surname: Fantozzi fullname: Fantozzi, G – sequence: 5 givenname: J-P surname: Carret fullname: Carret, J-P – sequence: 6 givenname: P surname: Chavassieux fullname: Chavassieux, P – sequence: 7 givenname: G surname: Boivin fullname: Boivin, G – sequence: 8 givenname: M surname: Melin fullname: Melin, M – sequence: 9 givenname: D surname: Hartmann fullname: Hartmann, D |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15348502$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | Kluwer Academic Publishers 2003 |
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| DOI | 10.1023/B:JMSM.0000004006.90399.b4 |
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| References | 10847976 - J Long Term Eff Med Implants. 1999;9(4):403-12 9468047 - J Biomed Mater Res. 1998 Mar 5;39(3):390-7 10509190 - Biomaterials. 1999 Oct;20(19):1799-806 6606682 - J Immunol Methods. 1983 Dec 16;65(1-2):55-63 15347932 - J Mater Sci Mater Med. 1999 Feb;10(2):111-20 9678860 - Biomaterials. 1998 Jan-Feb;19(1-3):133-9 12610435 - Rev Chir Orthop Reparatrice Appar Mot. 2003 Feb;89(1):44-52 12209909 - J Biomed Mater Res. 2002;63(5):619-26 2777831 - J Biomed Mater Res. 1989 Aug;23(8):883-94 11374457 - Biomaterials. 2001 Jun;22(12):1579-82 8380596 - J Biomed Mater Res. 1993 Jan;27(1):25-34 |
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| Snippet | The control of porosity morphology and physico-chemical characteristics of calcium phosphate bone substitutes is a key-point to guaranty healing success. In... Micro- and macroporosity of materials processed with 70% hydroxyapatite and 30% beta-tricalcium phosphate were controlled by sintering temperature and porogen... |
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| SubjectTerms | Biomedical materials Cellular Interconnection Macroporosity Materials science Mechanical properties Microporosity Morphology Porosity Scanning electron microscopy Surgical implants |
| Title | Effect of micro- and macroporosity of bone substitutes on their mechanical properties and cellular response |
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