High Glucose Impairs Early and Late Endothelial Progenitor Cells by Modifying Nitric Oxide–Related but Not Oxidative Stress–Mediated Mechanisms

• Published in: Diabetes (New York, N.Y.) Vol. 56; no. 6; pp. 1559 - 1568
• Main Authors: Chen, Yung-Hsiang, Lin, Shing-Jong, Lin, Feng-Yen, Wu, Tao-Cheng, Tsao, Chen-Rong, Huang, Po-Hsun, Liu, Po-Len, Chen, Yuh-Lien, Chen, Jaw-Wen
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.06.2007
• Subjects: Adult; Angiogenesis; Biological and medical sciences; Bone marrow; Causes of; Cell Division - drug effects; Cell Movement; Cell Separation - methods; Cellular Senescence; Colony-Forming Units Assay; Diabetes; Diabetes. Impaired glucose tolerance; Diabetic angiopathies; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Endothelium, Vascular - cytology; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiology; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Glucose; Glucose - pharmacology; Humans; Hyperglycemia; Kinases; Kinetics; Leukocytes, Mononuclear - physiology; Mannitol - pharmacology; Medical sciences; Neovascularization; Neovascularization, Physiologic; Nitric oxide; Nitric Oxide - physiology; Nitric Oxide Synthase Type III - metabolism; Oxidative stress; Oxidative Stress - drug effects; Oxidative Stress - physiology; Phosphorylation; Physiological aspects; Polyethylene glycol; Proteins; Research design; Senescence; Stem Cells - cytology; Stem Cells - drug effects; Stem Cells - physiology; Vascular endothelial growth factor; Vitamin C; Taiwan; Endocrinopathy; Oxidative stress; Endothelial cell; Nitric oxide; Diabetes mellitus; Precursor cell; Glucose

High Glucose Impairs Early and Late Endothelial Progenitor Cells by Modifying Nitric Oxide–Related but Not Oxidative Stress–Mediated Mechanisms Yung-Hsiang Chen 1 2 3 , Shing-Jong Lin 1 2 4 , Feng-Yen Lin 1 4 , Tao-Cheng Wu 1 2 4 , Chen-Rong Tsao 1 5 , Po-Hsun Huang 1 2 4 , Po-Len Liu 6 , Yuh-Lien C...