Validating a functional near-infrared spectroscopy diagnostic paradigm for Major Depressive Disorder

• Published in: Scientific reports Vol. 10; no. 1; p. 9740
• Main Authors: Husain, Syeda Fabeha, Yu, Rongjun, Tang, Tong-Boon, Tam, Wilson W., Tran, Bach, Quek, Travis T., Hwang, Shi-Hui, Chang, Cheryl W., Ho, Cyrus S., Ho, Roger C.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.06.2020; Nature Publishing Group
• Subjects: 631/378; 692/53; Adult; Biomarkers; Brain - physiopathology; Case-Control Studies; Depressive Disorder, Major - diagnostic imaging; Drug therapy; Female; Frontal Lobe - physiopathology; Hemodynamics - physiology; Hemoglobin; Humanities and Social Sciences; Humans; I.R. radiation; Infrared spectroscopy; Male; Mental depression; Middle Aged; multidisciplinary; Neuropsychological Tests; Neurovascular Coupling - physiology; Oxyhemoglobins - metabolism; Prefrontal Cortex - metabolism; Prefrontal Cortex - physiopathology; Psychiatric Status Rating Scales; Reproducibility of Results; Science; Science (multidisciplinary); Severity of Illness Index; Social interactions; Spectroscopy, Near-Infrared - methods; Spectrum analysis; Temporal Lobe - physiopathology

Reduced haemodynamic response in the frontotemporal cortices of patients with major depressive disorder (MDD) has been demonstrated using functional near-infrared spectroscopy (fNIRS). Most notably, changes in cortical oxy-haemoglobin during a Japanese phonetic fluency task can differentiate psychia...