Oncogenic H-Ras Reprograms Madin-Darby Canine Kidney (MDCK) Cell-derived Exosomal Proteins Following Epithelial-Mesenchymal Transition

• Published in: Molecular & cellular proteomics Vol. 12; no. 8; pp. 2148 - 2159
• Main Authors: Tauro, Bow J., Mathias, Rommel A., Greening, David W., Gopal, Shashi K., Ji, Hong, Kapp, Eugene A., Coleman, Bradley M., Hill, Andrew F., Kusebauch, Ulrike, Hallows, Janice L., Shteynberg, David, Moritz, Robert L., Zhu, Hong-Jian, Simpson, Richard J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2013; The American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Annexins - metabolism; Cell Transformation, Neoplastic - metabolism; Dogs; Epithelial-Mesenchymal Transition; Exosomes - metabolism; Genes, ras; Integrins - metabolism; Madin Darby Canine Kidney Cells; Peptide Hydrolases - metabolism; Proteome; ras Proteins - metabolism; Tetraspanins - metabolism

Epithelial-mesenchymal transition (EMT) is a highly conserved morphogenic process defined by the loss of epithelial characteristics and the acquisition of a mesenchymal phenotype. EMT is associated with increased aggressiveness, invasiveness, and metastatic potential in carcinoma cells. To assess th...