Apobec3 Encodes Rfv3, a Gene Influencing Neutralizing Antibody Control of Retrovirus Infection

• Published in: Science (American Association for the Advancement of Science) Vol. 321; no. 5894; pp. 1343 - 1346
• Main Authors: Santiago, Mario L, Montano, Mauricio, Benitez, Robert, Messer, Ronald J, Yonemoto, Wes, Chesebro, Bruce, Hasenkrug, Kim J, Greene, Warner C
• Format: Journal Article
• Language: English
• Published: Washington, DC American Association for the Advancement of Science 05.09.2008; The American Association for the Advancement of Science
• Subjects: Animals; Antibodies; Antibodies, Viral - biosynthesis; Antibodies, Viral - blood; Antibodies, Viral - immunology; Biological and medical sciences; Chromosome Mapping; Chromosomes; Cloning, Molecular; Cytidine Deaminase - genetics; Cytidine Deaminase - metabolism; Exons; Friend murine leukemia virus - immunology; Friend murine leukemia virus - physiology; Fundamental and applied biological sciences. Psychology; Genes; Genetics; Human immunodeficiency virus; Immunity, Innate; Infections; Messenger RNA; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microbiology; Molecular Sequence Data; Neutralization Tests; Neutralizing antibodies; Phenotypes; Proteins; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains; Retroviridae Infections - genetics; Retroviridae Infections - immunology; Retroviridae Infections - virology; Rodents; Tumor Virus Infections - genetics; Tumor Virus Infections - immunology; Tumor Virus Infections - virology; Viremia; Virology; Viruses; Immune response; Rodentia; Retroviridae; Neutralizing antibody; Infection; Virus; Vertebrata; Gammaretrovirus; Mammalia; Sensitivity resistance; Mouse; Viral disease; Friend murine leukemia virus; Humoral immunity

Recovery from Friend virus 3 (Rfv3) is a single autosomal gene encoding a resistance trait that influences retroviral neutralizing antibody responses and viremia. Despite extensive research for 30 years, the molecular identity of Rfv3 has remained elusive. Here, we demonstrate that Rfv3 is encoded b...