Conjugated equine estrogen used in postmenopausal women associated with a higher risk of stroke than estradiol

• Published in: Scientific reports Vol. 11; no. 1; pp. 10801 - 8
• Main Authors: Chang, Wei-Chuan, Wang, Jen-Hung, Ding, Dah-Ching
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.05.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 17β-Estradiol; 692/308; 692/4019; 692/700; Administration, Oral; Adult; Estradiol - administration & dosage; Estradiol - adverse effects; Estrogen Replacement Therapy - adverse effects; Estrogens; Estrogens, Conjugated (USP) - administration & dosage; Estrogens, Conjugated (USP) - adverse effects; Female; Health risks; Humanities and Social Sciences; Humans; Incidence; Ischemia; Ischemic Stroke - chemically induced; Ischemic Stroke - epidemiology; Menopause; Middle Aged; multidisciplinary; Post-menopause; Postmenopause; Propensity Score; Regression analysis; Retrospective Studies; Science; Science (multidisciplinary); Stroke; Taiwan - epidemiology; Taiwan
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-90357-6

This study aimed to evaluate the risk of ischemic stroke (IS) in hormone therapy (HT) with oral conjugated equine estrogen (CEE) and estradiol (E2) in postmenopausal women in Taiwan. A retrospective cohort study was conducted using the Taiwan National Health Insurance Research Database, a population...