Natural killer cells direct hemochorial placentation by regulating hypoxia-inducible factor dependent trophoblast lineage decisions

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 108; no. 39; pp. 16295 - 16300
• Main Authors: Chakraborty, Damayanti, Rumi, M. A. Karim, Konno, Toshihiro, Soares, Michael J
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 27.09.2011; National Acad Sciences
• Subjects: Animals; Arteries; Biological Sciences; Cell Lineage; Cells; Differentiation; Endothelium; Female; Genotype & phenotype; Hypoxia; Hypoxia-inducible factor 1 alpha; Hypoxia-Inducible Factor 1, alpha Subunit - physiology; Hypoxia-inducible factors; Killer Cells, Natural - physiology; Natural killer cells; Oxygen; Oxygen - metabolism; Oxygen tension; phenotype; Placenta; Placenta - blood supply; Placenta - cytology; Placenta - metabolism; Placentation; Pregnancy; Proteins; Rats; Rats, Sprague-Dawley; Reflexes; Renovations; Signal Transduction; Stem cells; Stroma; trophoblast; Trophoblasts; Trophoblasts - cytology; Uterus

Natural killer (NK) cells are recruited into the uterine stroma during establishment of the hemochorial placenta and are proposed regulators of uterine spiral artery remodeling. Failures in uterine spiral artery remodeling are linked to diseases of pregnancy. This prompted an investigation of the in...