Blood pressure is associated with higher brain amyloid burden and lower glucose metabolism in healthy late middle-age persons

• Published in: Neurobiology of aging Vol. 33; no. 4; pp. 827.e11 - 827.e19
• Main Authors: Langbaum, Jessica B.S., Chen, Kewei, Launer, Lenore J., Fleisher, Adam S., Lee, Wendy, Liu, Xiaofen, Protas, Hillary D., Reeder, Stephanie A., Bandy, Daniel, Yu, Meixiang, Caselli, Richard J., Reiman, Eric M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2012
• Subjects: Age Factors; Aged; Alzheimer's disease; Amyloid; Amyloid beta-Peptides - metabolism; Aniline Compounds - metabolism; APOE; Apolipoprotein E4 - genetics; Arterial stiffness; Blood pressure; Blood Pressure - genetics; Blood Pressure - physiology; Brain - diagnostic imaging; Brain - metabolism; Brain imaging; Brain Mapping; Female; Fluorodeoxyglucose F18 - metabolism; Glucose - metabolism; Humans; Internal Medicine; Male; Middle Aged; Neurology; PET; PiB; Pittsburgh Compound-B; Positron-Emission Tomography; Thiazoles - metabolism; Brain imaging; Arterial stiffness; PiB; Pittsburgh Compound-B; Blood pressure; Amyloid; APOE; Alzheimer's disease; PET

Epidemiological studies suggest that elevated blood pressure (BP) in midlife is associated with increased risk of Alzheimer's disease (AD) in late life. In this preliminary study, we investigated the extent to which BP measurements are related to positron emission tomography (PET) measurements...