Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies

• Published in: Biotechnology advances Vol. 37; no. 1; pp. 177 - 192
• Main Authors: Pang, Zheng, Raudonis, Renee, Glick, Bernard R., Lin, Tong-Jun, Cheng, Zhenyu
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.01.2019; Elsevier Science Ltd
• Subjects: alternative therapeutics; antibiotic resistance; Antibiotics; Cystic fibrosis; Drug resistance; immunocompromised population; Infections; morbidity; mortality; multiple drug resistance; new antibiotics; Pathogens; patients; Pseudomonas aeruginosa; relapse; resistance mechanisms; secondary infection; therapeutics; new antibiotics; Pseudomonas aeruginosa; alternative therapeutics; antibiotic resistance; resistance mechanisms

Pseudomonas aeruginosa is an opportunistic pathogen that is a leading cause of morbidity and mortality in cystic fibrosis patients and immunocompromised individuals. Eradication of P. aeruginosa has become increasingly difficult due to its remarkable capacity to resist antibiotics. Strains of Pseudo...