Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies
Pseudomonas aeruginosa is an opportunistic pathogen that is a leading cause of morbidity and mortality in cystic fibrosis patients and immunocompromised individuals. Eradication of P. aeruginosa has become increasingly difficult due to its remarkable capacity to resist antibiotics. Strains of Pseudo...
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| Published in | Biotechnology advances Vol. 37; no. 1; pp. 177 - 192 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Inc
01.01.2019
Elsevier Science Ltd |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Pseudomonas aeruginosa is an opportunistic pathogen that is a leading cause of morbidity and mortality in cystic fibrosis patients and immunocompromised individuals. Eradication of P. aeruginosa has become increasingly difficult due to its remarkable capacity to resist antibiotics. Strains of Pseudomonas aeruginosa are known to utilize their high levels of intrinsic and acquired resistance mechanisms to counter most antibiotics. In addition, adaptive antibiotic resistance of P. aeruginosa is a recently characterized mechanism, which includes biofilm-mediated resistance and formation of multidrug-tolerant persister cells, and is responsible for recalcitrance and relapse of infections. The discovery and development of alternative therapeutic strategies that present novel avenues against P. aeruginosa infections are increasingly demanded and gaining more and more attention. Although mostly at the preclinical stages, many recent studies have reported several innovative therapeutic technologies that have demonstrated pronounced effectiveness in fighting against drug-resistant P. aeruginosa strains. This review highlights the mechanisms of antibiotic resistance in P. aeruginosa and discusses the current state of some novel therapeutic approaches for treatment of P. aeruginosa infections that can be further explored in clinical practice. |
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| AbstractList | Pseudomonas aeruginosa is an opportunistic pathogen that is a leading cause of morbidity and mortality in cystic fibrosis patients and immunocompromised individuals. Eradication of P. aeruginosa has become increasingly difficult due to its remarkable capacity to resist antibiotics. Strains of Pseudomonas aeruginosa are known to utilize their high levels of intrinsic and acquired resistance mechanisms to counter most antibiotics. In addition, adaptive antibiotic resistance of P. aeruginosa is a recently characterized mechanism, which includes biofilm-mediated resistance and formation of multidrug-tolerant persister cells, and is responsible for recalcitrance and relapse of infections. The discovery and development of alternative therapeutic strategies that present novel avenues against P. aeruginosa infections are increasingly demanded and gaining more and more attention. Although mostly at the preclinical stages, many recent studies have reported several innovative therapeutic technologies that have demonstrated pronounced effectiveness in fighting against drug-resistant P. aeruginosa strains. This review highlights the mechanisms of antibiotic resistance in P. aeruginosa and discusses the current state of some novel therapeutic approaches for treatment of P. aeruginosa infections that can be further explored in clinical practice. Pseudomonas aeruginosa is an opportunistic pathogen that is a leading cause of morbidity and mortality in cystic fibrosis patients and immunocompromised individuals. Eradication of P. aeruginosa has become increasingly difficult due to its remarkable capacity to resist antibiotics. Strains of Pseudomonas aeruginosa are known to utilize their high levels of intrinsic and acquired resistance mechanisms to counter most antibiotics. In addition, adaptive antibiotic resistance of P. aeruginosa is a recently characterized mechanism, which includes biofilm-mediated resistance and formation of multidrug-tolerant persister cells, and is responsible for recalcitrance and relapse of infections. The discovery and development of alternative therapeutic strategies that present novel avenues against P. aeruginosa infections are increasingly demanded and gaining more and more attention. Although mostly at the preclinical stages, many recent studies have reported several innovative therapeutic technologies that have demonstrated pronounced effectiveness in fighting against drug-resistant P. aeruginosa strains. This review highlights the mechanisms of antibiotic resistance in P. aeruginosa and discusses the current state of some novel therapeutic approaches for treatment of P. aeruginosa infections that can be further explored in clinical practice.Pseudomonas aeruginosa is an opportunistic pathogen that is a leading cause of morbidity and mortality in cystic fibrosis patients and immunocompromised individuals. Eradication of P. aeruginosa has become increasingly difficult due to its remarkable capacity to resist antibiotics. Strains of Pseudomonas aeruginosa are known to utilize their high levels of intrinsic and acquired resistance mechanisms to counter most antibiotics. In addition, adaptive antibiotic resistance of P. aeruginosa is a recently characterized mechanism, which includes biofilm-mediated resistance and formation of multidrug-tolerant persister cells, and is responsible for recalcitrance and relapse of infections. The discovery and development of alternative therapeutic strategies that present novel avenues against P. aeruginosa infections are increasingly demanded and gaining more and more attention. Although mostly at the preclinical stages, many recent studies have reported several innovative therapeutic technologies that have demonstrated pronounced effectiveness in fighting against drug-resistant P. aeruginosa strains. This review highlights the mechanisms of antibiotic resistance in P. aeruginosa and discusses the current state of some novel therapeutic approaches for treatment of P. aeruginosa infections that can be further explored in clinical practice. |
| Author | Cheng, Zhenyu Glick, Bernard R. Raudonis, Renee Pang, Zheng Lin, Tong-Jun |
| Author_xml | – sequence: 1 givenname: Zheng surname: Pang fullname: Pang, Zheng organization: Department of Pathology, Dalhousie University, Halifax, NS B3H 4R2, Canada – sequence: 2 givenname: Renee surname: Raudonis fullname: Raudonis, Renee organization: Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H 4R2, Canada – sequence: 3 givenname: Bernard R. surname: Glick fullname: Glick, Bernard R. organization: Department of Biology, University of Waterloo, Waterloo, ON N2L 3G1, Canada – sequence: 4 givenname: Tong-Jun surname: Lin fullname: Lin, Tong-Jun organization: Department of Pathology, Dalhousie University, Halifax, NS B3H 4R2, Canada – sequence: 5 givenname: Zhenyu orcidid: 0000-0002-7240-9126 surname: Cheng fullname: Cheng, Zhenyu email: zhenyu.cheng@dal.ca organization: Department of Pathology, Dalhousie University, Halifax, NS B3H 4R2, Canada |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30500353$$D View this record in MEDLINE/PubMed |
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| OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S0734975018301976 |
| PMID | 30500353 |
| PQID | 2176698580 |
| PQPubID | 2047478 |
| PageCount | 16 |
| ParticipantIDs | proquest_miscellaneous_2221023963 proquest_miscellaneous_2149022999 proquest_journals_2176698580 pubmed_primary_30500353 crossref_citationtrail_10_1016_j_biotechadv_2018_11_013 crossref_primary_10_1016_j_biotechadv_2018_11_013 elsevier_sciencedirect_doi_10_1016_j_biotechadv_2018_11_013 |
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| PublicationCentury | 2000 |
| PublicationDate | January-February 2019 2019-01-00 2019 Jan - Feb 20190101 |
| PublicationDateYYYYMMDD | 2019-01-01 |
| PublicationDate_xml | – month: 01 year: 2019 text: January-February 2019 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England – name: Oxford |
| PublicationTitle | Biotechnology advances |
| PublicationTitleAlternate | Biotechnol Adv |
| PublicationYear | 2019 |
| Publisher | Elsevier Inc Elsevier Science Ltd |
| Publisher_xml | – name: Elsevier Inc – name: Elsevier Science Ltd |
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| SubjectTerms | alternative therapeutics antibiotic resistance Antibiotics Cystic fibrosis Drug resistance immunocompromised population Infections morbidity mortality multiple drug resistance new antibiotics Pathogens patients Pseudomonas aeruginosa relapse resistance mechanisms secondary infection therapeutics |
| Title | Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies |
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