Older adults lack SARS CoV-2 cross-reactive T lymphocytes directed to human coronaviruses OC43 and NL63

• Published in: Scientific reports Vol. 10; no. 1; pp. 21447 - 10
• Main Authors: Saletti, Giulietta, Gerlach, Thomas, Jansen, Janina M., Molle, Antonia, Elbahesh, Husni, Ludlow, Martin, Li, Wentao, Bosch, Berend-Jan, Osterhaus, Albert D. M. E., Rimmelzwaan, Guus F.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.12.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326/596/2553; 631/326/596/4130; Adult; Age; Aged; Antibodies, Viral - immunology; Cell-mediated immunity; Coronaviridae; Coronavirus NL63, Human - immunology; Coronavirus OC43, Human - immunology; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - pathology; Cross Reactions - immunology; Humanities and Social Sciences; Humans; Immunity, Cellular - immunology; Infections; Lymphocytes; Lymphocytes T; Middle Aged; Morbidity; Mortality; multidisciplinary; Older people; Pandemics; SARS-CoV-2 - immunology; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Severity of Illness Index; Spike Glycoprotein, Coronavirus - immunology; T-Lymphocytes - immunology; Young Adult; Young adults

Currently, infections with SARS-Coronavirus-2 (SARS-CoV-2), the causative agent of the COVID-19 pandemic, are responsible for substantial morbidity and mortality worldwide. Older adults subjects > 60 years of age account for > 95% of the over one million fatal cases reported to date. It is unc...