Sur7 promotes plasma membrane organization and is needed for resistance to stressful conditions and to the invasive growth and virulence of Candida albicans

• Published in: mBio Vol. 3; no. 1
• Main Authors: Douglas, Lois M, Wang, Hong X, Keppler-Ross, Sabine, Dean, Neta, Konopka, James B
• Format: Journal Article
• Language: English
• Published: United States American Society of Microbiology 01.01.2012; American Society for Microbiology
• Subjects: Animals; Candida albicans - genetics; Candida albicans - growth & development; Candida albicans - metabolism; Candida albicans - pathogenicity; Candidiasis - parasitology; Candidiasis - pathology; Cell Line; Cell Membrane - metabolism; Cell Survival; Copper - metabolism; Disease Models, Animal; Gene Deletion; Histocytochemistry; Kidney - parasitology; Macrophages - parasitology; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mice, Inbred BALB C; Microscopy; Mutant Proteins - genetics; Mutant Proteins - metabolism; Oxidation-Reduction; Phagosomes - parasitology; Survival Analysis; Virulence; Virulence Factors - genetics; Virulence Factors - metabolism

The human fungal pathogen Candida albicans causes lethal systemic infections because of its ability to grow and disseminate in a host. The C. albicans plasma membrane is essential for virulence by acting as a protective barrier and through its key roles in interfacing with the environment, secretion...