White matter integrity in young medication-naïve bipolar II depressed adults

It is unknown if young medication-naïve bipolar II (BPII) depressed patients have increased white matter (WM) disruptions. 27 each of young (average 23 years) and treatment-naïve BPII depressed, unipolar depressed (UD) patients and age–sex–education matched healthy controls (HC) underwent 3 T MRIs w...

Full description

Saved in:
Bibliographic Details
Published inScientific reports Vol. 11; no. 1; pp. 1816 - 10
Main Authors Mak, Arthur Dun Ping, Leung, Owen Ngo Wang, Chou, Idy Wing Yi, Wong, Sheila Lok Yiu, Chu, Winnie Chiu-wing, Yeung, David, So, Suzanne Ho-wai, Ma, Suk Ling, Lam, Linda Chiu Wah, Leung, Chi Ming, Lee, Sing
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 19.01.2021
Nature Publishing Group
Nature Portfolio
Subjects
692/699/476/1333
692/699/476/1414
Affective disorders
Discriminant analysis
Humanities and Social Sciences
Longitudinal studies
Magnetic resonance imaging
Mental depression
multidisciplinary
Patients
Principal components analysis
Science
Science (multidisciplinary)
Substantia alba
Online AccessGet full text

Cover

Abstract It is unknown if young medication-naïve bipolar II (BPII) depressed patients have increased white matter (WM) disruptions. 27 each of young (average 23 years) and treatment-naïve BPII depressed, unipolar depressed (UD) patients and age–sex–education matched healthy controls (HC) underwent 3 T MRIs with diffusion tensor imaging. Diagnostic ratings included Structured Clinical Interview for DSM Disorders (SCID), Montgomery-Åsberg Depression Rating Scale (MADRS), Young Mania Rating Scale (YMRS) and Hamilton Anxiety Rating Scale (HAM-A). Patients were clinically depressed (MADRS-BPII: 26.15 [SD9.25], UD: 25.56 [5.24], p = 0.86). Compared to UD, BPII had increased family bipolarity (BPII 13.6% vs UD 2.5%, p = 0.01, φc = 0.28), hypomanic symptoms (YMRS-BPII: 4.22 [4.24], UD: 1.33 [2], p = 0.02, d = 0.87), lifetime number of depressive episodes (BPII: 2.37 [1.23], UD: 1.44 [0.75], p = 0.02, d = 0.91), lifetime and current-year number of episodes (lifetime BPII: 50.85 [95.47], UD: 1.7 [1.03]; current-year BPII: 9.93 [16.29], UD: 1.11 [0.32], ps = 0.04, ds = 0.73–0.77) and longer illness duration (BPII: 4.96 years [3.96], UD: 2.99 [3.33], p = 0.15, d = 0.54). BPII showed no increased WM disruptions vs UD or HC in any of the 15 a priori WM tracts. UD had lower right superior longitudinal fasciculus (SLF) (temporal) axial diffusivity (AD) (1.14 vs 1.17 (BPII), 1.16 (HC); F = 6.93, 95% CI of F B : 0.00073, 5.22, ηp 2  = 0.15). Principal component analysis followed by exploratory linear discriminant analysis showed that increased R-SLF (temporal) AD, YMRS and family bipolarity distinguished BPII from UD (81.5% sensitivity, 85.2% specificity) independent of episode number and frequency. Young, medication-naïve adults with BPII depression did not show the WM disruptions distinguishing more chronically ill BP patients from UD. These WM disruptions may therefore be partly attributable to illness chronicity. Longitudinal studies should examine the trajectory of WM changes in BPII and UD and predictive validity of these baseline clinical and imaging parameters.
AbstractList It is unknown if young medication-naïve bipolar II (BPII) depressed patients have increased white matter (WM) disruptions. 27 each of young (average 23 years) and treatment-naïve BPII depressed, unipolar depressed (UD) patients and age–sex–education matched healthy controls (HC) underwent 3 T MRIs with diffusion tensor imaging. Diagnostic ratings included Structured Clinical Interview for DSM Disorders (SCID), Montgomery-Åsberg Depression Rating Scale (MADRS), Young Mania Rating Scale (YMRS) and Hamilton Anxiety Rating Scale (HAM-A). Patients were clinically depressed (MADRS-BPII: 26.15 [SD9.25], UD: 25.56 [5.24], p = 0.86). Compared to UD, BPII had increased family bipolarity (BPII 13.6% vs UD 2.5%, p = 0.01, φc = 0.28), hypomanic symptoms (YMRS-BPII: 4.22 [4.24], UD: 1.33 [2], p = 0.02, d = 0.87), lifetime number of depressive episodes (BPII: 2.37 [1.23], UD: 1.44 [0.75], p = 0.02, d = 0.91), lifetime and current-year number of episodes (lifetime BPII: 50.85 [95.47], UD: 1.7 [1.03]; current-year BPII: 9.93 [16.29], UD: 1.11 [0.32], ps = 0.04, ds = 0.73–0.77) and longer illness duration (BPII: 4.96 years [3.96], UD: 2.99 [3.33], p = 0.15, d = 0.54). BPII showed no increased WM disruptions vs UD or HC in any of the 15 a priori WM tracts. UD had lower right superior longitudinal fasciculus (SLF) (temporal) axial diffusivity (AD) (1.14 vs 1.17 (BPII), 1.16 (HC); F = 6.93, 95% CI of $${F}_{B}$$ F B : 0.00073, 5.22, ηp 2  = 0.15). Principal component analysis followed by exploratory linear discriminant analysis showed that increased R-SLF (temporal) AD, YMRS and family bipolarity distinguished BPII from UD (81.5% sensitivity, 85.2% specificity) independent of episode number and frequency. Young, medication-naïve adults with BPII depression did not show the WM disruptions distinguishing more chronically ill BP patients from UD. These WM disruptions may therefore be partly attributable to illness chronicity. Longitudinal studies should examine the trajectory of WM changes in BPII and UD and predictive validity of these baseline clinical and imaging parameters.
Abstract It is unknown if young medication-naïve bipolar II (BPII) depressed patients have increased white matter (WM) disruptions. 27 each of young (average 23 years) and treatment-naïve BPII depressed, unipolar depressed (UD) patients and age–sex–education matched healthy controls (HC) underwent 3 T MRIs with diffusion tensor imaging. Diagnostic ratings included Structured Clinical Interview for DSM Disorders (SCID), Montgomery-Åsberg Depression Rating Scale (MADRS), Young Mania Rating Scale (YMRS) and Hamilton Anxiety Rating Scale (HAM-A). Patients were clinically depressed (MADRS-BPII: 26.15 [SD9.25], UD: 25.56 [5.24], p = 0.86). Compared to UD, BPII had increased family bipolarity (BPII 13.6% vs UD 2.5%, p = 0.01, φc = 0.28), hypomanic symptoms (YMRS-BPII: 4.22 [4.24], UD: 1.33 [2], p = 0.02, d = 0.87), lifetime number of depressive episodes (BPII: 2.37 [1.23], UD: 1.44 [0.75], p = 0.02, d = 0.91), lifetime and current-year number of episodes (lifetime BPII: 50.85 [95.47], UD: 1.7 [1.03]; current-year BPII: 9.93 [16.29], UD: 1.11 [0.32], ps = 0.04, ds = 0.73–0.77) and longer illness duration (BPII: 4.96 years [3.96], UD: 2.99 [3.33], p = 0.15, d = 0.54). BPII showed no increased WM disruptions vs UD or HC in any of the 15 a priori WM tracts. UD had lower right superior longitudinal fasciculus (SLF) (temporal) axial diffusivity (AD) (1.14 vs 1.17 (BPII), 1.16 (HC); F = 6.93, 95% CI of $${F}_{B}$$ F B : 0.00073, 5.22, ηp2 = 0.15). Principal component analysis followed by exploratory linear discriminant analysis showed that increased R-SLF (temporal) AD, YMRS and family bipolarity distinguished BPII from UD (81.5% sensitivity, 85.2% specificity) independent of episode number and frequency. Young, medication-naïve adults with BPII depression did not show the WM disruptions distinguishing more chronically ill BP patients from UD. These WM disruptions may therefore be partly attributable to illness chronicity. Longitudinal studies should examine the trajectory of WM changes in BPII and UD and predictive validity of these baseline clinical and imaging parameters.
It is unknown if young medication-naïve bipolar II (BPII) depressed patients have increased white matter (WM) disruptions. 27 each of young (average 23 years) and treatment-naïve BPII depressed, unipolar depressed (UD) patients and age–sex–education matched healthy controls (HC) underwent 3 T MRIs with diffusion tensor imaging. Diagnostic ratings included Structured Clinical Interview for DSM Disorders (SCID), Montgomery-Åsberg Depression Rating Scale (MADRS), Young Mania Rating Scale (YMRS) and Hamilton Anxiety Rating Scale (HAM-A). Patients were clinically depressed (MADRS-BPII: 26.15 [SD9.25], UD: 25.56 [5.24], p = 0.86). Compared to UD, BPII had increased family bipolarity (BPII 13.6% vs UD 2.5%, p = 0.01, φc = 0.28), hypomanic symptoms (YMRS-BPII: 4.22 [4.24], UD: 1.33 [2], p = 0.02, d = 0.87), lifetime number of depressive episodes (BPII: 2.37 [1.23], UD: 1.44 [0.75], p = 0.02, d = 0.91), lifetime and current-year number of episodes (lifetime BPII: 50.85 [95.47], UD: 1.7 [1.03]; current-year BPII: 9.93 [16.29], UD: 1.11 [0.32], ps = 0.04, ds = 0.73–0.77) and longer illness duration (BPII: 4.96 years [3.96], UD: 2.99 [3.33], p = 0.15, d = 0.54). BPII showed no increased WM disruptions vs UD or HC in any of the 15 a priori WM tracts. UD had lower right superior longitudinal fasciculus (SLF) (temporal) axial diffusivity (AD) (1.14 vs 1.17 (BPII), 1.16 (HC); F = 6.93, 95% CI ofFB: 0.00073, 5.22, ηp2 = 0.15). Principal component analysis followed by exploratory linear discriminant analysis showed that increased R-SLF (temporal) AD, YMRS and family bipolarity distinguished BPII from UD (81.5% sensitivity, 85.2% specificity) independent of episode number and frequency. Young, medication-naïve adults with BPII depression did not show the WM disruptions distinguishing more chronically ill BP patients from UD. These WM disruptions may therefore be partly attributable to illness chronicity. Longitudinal studies should examine the trajectory of WM changes in BPII and UD and predictive validity of these baseline clinical and imaging parameters.
It is unknown if young medication-naïve bipolar II (BPII) depressed patients have increased white matter (WM) disruptions. 27 each of young (average 23 years) and treatment-naïve BPII depressed, unipolar depressed (UD) patients and age–sex–education matched healthy controls (HC) underwent 3 T MRIs with diffusion tensor imaging. Diagnostic ratings included Structured Clinical Interview for DSM Disorders (SCID), Montgomery-Åsberg Depression Rating Scale (MADRS), Young Mania Rating Scale (YMRS) and Hamilton Anxiety Rating Scale (HAM-A). Patients were clinically depressed (MADRS-BPII: 26.15 [SD9.25], UD: 25.56 [5.24], p = 0.86). Compared to UD, BPII had increased family bipolarity (BPII 13.6% vs UD 2.5%, p = 0.01, φc = 0.28), hypomanic symptoms (YMRS-BPII: 4.22 [4.24], UD: 1.33 [2], p = 0.02, d = 0.87), lifetime number of depressive episodes (BPII: 2.37 [1.23], UD: 1.44 [0.75], p = 0.02, d = 0.91), lifetime and current-year number of episodes (lifetime BPII: 50.85 [95.47], UD: 1.7 [1.03]; current-year BPII: 9.93 [16.29], UD: 1.11 [0.32], ps = 0.04, ds = 0.73–0.77) and longer illness duration (BPII: 4.96 years [3.96], UD: 2.99 [3.33], p = 0.15, d = 0.54). BPII showed no increased WM disruptions vs UD or HC in any of the 15 a priori WM tracts. UD had lower right superior longitudinal fasciculus (SLF) (temporal) axial diffusivity (AD) (1.14 vs 1.17 (BPII), 1.16 (HC); F = 6.93, 95% CI of F B : 0.00073, 5.22, ηp 2  = 0.15). Principal component analysis followed by exploratory linear discriminant analysis showed that increased R-SLF (temporal) AD, YMRS and family bipolarity distinguished BPII from UD (81.5% sensitivity, 85.2% specificity) independent of episode number and frequency. Young, medication-naïve adults with BPII depression did not show the WM disruptions distinguishing more chronically ill BP patients from UD. These WM disruptions may therefore be partly attributable to illness chronicity. Longitudinal studies should examine the trajectory of WM changes in BPII and UD and predictive validity of these baseline clinical and imaging parameters.
It is unknown if young medication-naïve bipolar II (BPII) depressed patients have increased white matter (WM) disruptions. 27 each of young (average 23 years) and treatment-naïve BPII depressed, unipolar depressed (UD) patients and age-sex-education matched healthy controls (HC) underwent 3 T MRIs with diffusion tensor imaging. Diagnostic ratings included Structured Clinical Interview for DSM Disorders (SCID), Montgomery-Åsberg Depression Rating Scale (MADRS), Young Mania Rating Scale (YMRS) and Hamilton Anxiety Rating Scale (HAM-A). Patients were clinically depressed (MADRS-BPII: 26.15 [SD9.25], UD: 25.56 [5.24], p = 0.86). Compared to UD, BPII had increased family bipolarity (BPII 13.6% vs UD 2.5%, p = 0.01, φc = 0.28), hypomanic symptoms (YMRS-BPII: 4.22 [4.24], UD: 1.33 [2], p = 0.02, d = 0.87), lifetime number of depressive episodes (BPII: 2.37 [1.23], UD: 1.44 [0.75], p = 0.02, d = 0.91), lifetime and current-year number of episodes (lifetime BPII: 50.85 [95.47], UD: 1.7 [1.03]; current-year BPII: 9.93 [16.29], UD: 1.11 [0.32], ps = 0.04, ds = 0.73-0.77) and longer illness duration (BPII: 4.96 years [3.96], UD: 2.99 [3.33], p = 0.15, d = 0.54). BPII showed no increased WM disruptions vs UD or HC in any of the 15 a priori WM tracts. UD had lower right superior longitudinal fasciculus (SLF) (temporal) axial diffusivity (AD) (1.14 vs 1.17 (BPII), 1.16 (HC); F = 6.93, 95% CI of [Formula: see text]: 0.00073, 5.22, ηp2 = 0.15). Principal component analysis followed by exploratory linear discriminant analysis showed that increased R-SLF (temporal) AD, YMRS and family bipolarity distinguished BPII from UD (81.5% sensitivity, 85.2% specificity) independent of episode number and frequency. Young, medication-naïve adults with BPII depression did not show the WM disruptions distinguishing more chronically ill BP patients from UD. These WM disruptions may therefore be partly attributable to illness chronicity. Longitudinal studies should examine the trajectory of WM changes in BPII and UD and predictive validity of these baseline clinical and imaging parameters.It is unknown if young medication-naïve bipolar II (BPII) depressed patients have increased white matter (WM) disruptions. 27 each of young (average 23 years) and treatment-naïve BPII depressed, unipolar depressed (UD) patients and age-sex-education matched healthy controls (HC) underwent 3 T MRIs with diffusion tensor imaging. Diagnostic ratings included Structured Clinical Interview for DSM Disorders (SCID), Montgomery-Åsberg Depression Rating Scale (MADRS), Young Mania Rating Scale (YMRS) and Hamilton Anxiety Rating Scale (HAM-A). Patients were clinically depressed (MADRS-BPII: 26.15 [SD9.25], UD: 25.56 [5.24], p = 0.86). Compared to UD, BPII had increased family bipolarity (BPII 13.6% vs UD 2.5%, p = 0.01, φc = 0.28), hypomanic symptoms (YMRS-BPII: 4.22 [4.24], UD: 1.33 [2], p = 0.02, d = 0.87), lifetime number of depressive episodes (BPII: 2.37 [1.23], UD: 1.44 [0.75], p = 0.02, d = 0.91), lifetime and current-year number of episodes (lifetime BPII: 50.85 [95.47], UD: 1.7 [1.03]; current-year BPII: 9.93 [16.29], UD: 1.11 [0.32], ps = 0.04, ds = 0.73-0.77) and longer illness duration (BPII: 4.96 years [3.96], UD: 2.99 [3.33], p = 0.15, d = 0.54). BPII showed no increased WM disruptions vs UD or HC in any of the 15 a priori WM tracts. UD had lower right superior longitudinal fasciculus (SLF) (temporal) axial diffusivity (AD) (1.14 vs 1.17 (BPII), 1.16 (HC); F = 6.93, 95% CI of [Formula: see text]: 0.00073, 5.22, ηp2 = 0.15). Principal component analysis followed by exploratory linear discriminant analysis showed that increased R-SLF (temporal) AD, YMRS and family bipolarity distinguished BPII from UD (81.5% sensitivity, 85.2% specificity) independent of episode number and frequency. Young, medication-naïve adults with BPII depression did not show the WM disruptions distinguishing more chronically ill BP patients from UD. These WM disruptions may therefore be partly attributable to illness chronicity. Longitudinal studies should examine the trajectory of WM changes in BPII and UD and predictive validity of these baseline clinical and imaging parameters.
It is unknown if young medication-naïve bipolar II (BPII) depressed patients have increased white matter (WM) disruptions. 27 each of young (average 23 years) and treatment-naïve BPII depressed, unipolar depressed (UD) patients and age–sex–education matched healthy controls (HC) underwent 3 T MRIs with diffusion tensor imaging. Diagnostic ratings included Structured Clinical Interview for DSM Disorders (SCID), Montgomery-Åsberg Depression Rating Scale (MADRS), Young Mania Rating Scale (YMRS) and Hamilton Anxiety Rating Scale (HAM-A). Patients were clinically depressed (MADRS-BPII: 26.15 [SD9.25], UD: 25.56 [5.24], p = 0.86). Compared to UD, BPII had increased family bipolarity (BPII 13.6% vs UD 2.5%, p = 0.01, φc = 0.28), hypomanic symptoms (YMRS-BPII: 4.22 [4.24], UD: 1.33 [2], p = 0.02, d = 0.87), lifetime number of depressive episodes (BPII: 2.37 [1.23], UD: 1.44 [0.75], p = 0.02, d = 0.91), lifetime and current-year number of episodes (lifetime BPII: 50.85 [95.47], UD: 1.7 [1.03]; current-year BPII: 9.93 [16.29], UD: 1.11 [0.32], ps = 0.04, ds = 0.73–0.77) and longer illness duration (BPII: 4.96 years [3.96], UD: 2.99 [3.33], p = 0.15, d = 0.54). BPII showed no increased WM disruptions vs UD or HC in any of the 15 a priori WM tracts. UD had lower right superior longitudinal fasciculus (SLF) (temporal) axial diffusivity (AD) (1.14 vs 1.17 (BPII), 1.16 (HC); F = 6.93, 95% CI of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${F}_{B}$$\end{document} F B : 0.00073, 5.22, ηp 2  = 0.15). Principal component analysis followed by exploratory linear discriminant analysis showed that increased R-SLF (temporal) AD, YMRS and family bipolarity distinguished BPII from UD (81.5% sensitivity, 85.2% specificity) independent of episode number and frequency. Young, medication-naïve adults with BPII depression did not show the WM disruptions distinguishing more chronically ill BP patients from UD. These WM disruptions may therefore be partly attributable to illness chronicity. Longitudinal studies should examine the trajectory of WM changes in BPII and UD and predictive validity of these baseline clinical and imaging parameters.
It is unknown if young medication-naïve bipolar II (BPII) depressed patients have increased white matter (WM) disruptions. 27 each of young (average 23 years) and treatment-naïve BPII depressed, unipolar depressed (UD) patients and age-sex-education matched healthy controls (HC) underwent 3 T MRIs with diffusion tensor imaging. Diagnostic ratings included Structured Clinical Interview for DSM Disorders (SCID), Montgomery-Åsberg Depression Rating Scale (MADRS), Young Mania Rating Scale (YMRS) and Hamilton Anxiety Rating Scale (HAM-A). Patients were clinically depressed (MADRS-BPII: 26.15 [SD9.25], UD: 25.56 [5.24], p = 0.86). Compared to UD, BPII had increased family bipolarity (BPII 13.6% vs UD 2.5%, p = 0.01, φc = 0.28), hypomanic symptoms (YMRS-BPII: 4.22 [4.24], UD: 1.33 [2], p = 0.02, d = 0.87), lifetime number of depressive episodes (BPII: 2.37 [1.23], UD: 1.44 [0.75], p = 0.02, d = 0.91), lifetime and current-year number of episodes (lifetime BPII: 50.85 [95.47], UD: 1.7 [1.03]; current-year BPII: 9.93 [16.29], UD: 1.11 [0.32], ps = 0.04, ds = 0.73-0.77) and longer illness duration (BPII: 4.96 years [3.96], UD: 2.99 [3.33], p = 0.15, d = 0.54). BPII showed no increased WM disruptions vs UD or HC in any of the 15 a priori WM tracts. UD had lower right superior longitudinal fasciculus (SLF) (temporal) axial diffusivity (AD) (1.14 vs 1.17 (BPII), 1.16 (HC); F = 6.93, 95% CI of [Formula: see text]: 0.00073, 5.22, ηp  = 0.15). Principal component analysis followed by exploratory linear discriminant analysis showed that increased R-SLF (temporal) AD, YMRS and family bipolarity distinguished BPII from UD (81.5% sensitivity, 85.2% specificity) independent of episode number and frequency. Young, medication-naïve adults with BPII depression did not show the WM disruptions distinguishing more chronically ill BP patients from UD. These WM disruptions may therefore be partly attributable to illness chronicity. Longitudinal studies should examine the trajectory of WM changes in BPII and UD and predictive validity of these baseline clinical and imaging parameters.
ArticleNumber 1816
Author Lee, Sing
Wong, Sheila Lok Yiu
Chu, Winnie Chiu-wing
Lam, Linda Chiu Wah
Leung, Owen Ngo Wang
Yeung, David
Ma, Suk Ling
Chou, Idy Wing Yi
So, Suzanne Ho-wai
Leung, Chi Ming
Mak, Arthur Dun Ping
Author_xml – sequence: 1
  givenname: Arthur Dun Ping
  surname: Mak
  fullname: Mak, Arthur Dun Ping
  email: arthurdpmak@cuhk.edu.hk
  organization: Department of Psychiatry, G/F Multicentre, Tai Po Hospital, The Chinese University of Hong Kong
– sequence: 2
  givenname: Owen Ngo Wang
  surname: Leung
  fullname: Leung, Owen Ngo Wang
  organization: Department of Psychiatry, G/F Multicentre, Tai Po Hospital, The Chinese University of Hong Kong
– sequence: 3
  givenname: Idy Wing Yi
  surname: Chou
  fullname: Chou, Idy Wing Yi
  organization: Department of Psychiatry, G/F Multicentre, Tai Po Hospital, The Chinese University of Hong Kong
– sequence: 4
  givenname: Sheila Lok Yiu
  surname: Wong
  fullname: Wong, Sheila Lok Yiu
  organization: Department of Psychiatry, G/F Multicentre, Tai Po Hospital, The Chinese University of Hong Kong
– sequence: 5
  givenname: Winnie Chiu-wing
  surname: Chu
  fullname: Chu, Winnie Chiu-wing
  organization: Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong
– sequence: 6
  givenname: David
  surname: Yeung
  fullname: Yeung, David
  organization: Department of Clinical Oncology, Prince of Wales Hospital
– sequence: 7
  givenname: Suzanne Ho-wai
  surname: So
  fullname: So, Suzanne Ho-wai
  organization: Department of Psychology, The Chinese University of Hong Kong
– sequence: 8
  givenname: Suk Ling
  surname: Ma
  fullname: Ma, Suk Ling
  organization: Department of Psychiatry, G/F Multicentre, Tai Po Hospital, The Chinese University of Hong Kong
– sequence: 9
  givenname: Linda Chiu Wah
  surname: Lam
  fullname: Lam, Linda Chiu Wah
  organization: Department of Psychiatry, G/F Multicentre, Tai Po Hospital, The Chinese University of Hong Kong
– sequence: 10
  givenname: Chi Ming
  surname: Leung
  fullname: Leung, Chi Ming
  organization: Department of Psychiatry, G/F Multicentre, Tai Po Hospital, The Chinese University of Hong Kong
– sequence: 11
  givenname: Sing
  surname: Lee
  fullname: Lee, Sing
  organization: Department of Psychiatry, G/F Multicentre, Tai Po Hospital, The Chinese University of Hong Kong
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33469064$$D View this record in MEDLINE/PubMed
BookMark eNp9UstuFDEQtFAiEkJ-gAMaiQuXIX7u2BckFBFYKSiXII6WZ9wz8WrWXmxPpP0qPoIfi3cngSSH-GLLXVWq7q436MAHDwi9I_gTwUyeJU6EkjWmpJaECVGrV-iYYi5qyig9ePQ-QqcprXA5gipO1Gt0xBhfKLzgx-jHrxuXoVqbnCFWzmcYosvb8qq2YfJDtQbrOpNd8LU3f__cQtW6TRhNrJbLysImQkpgK2OnMae36LA3Y4LT-_sE_bz4en3-vb68-rY8_3JZd0LKXAvWkEYYpqwiglJhe0ostVwQBn1pptSEsoxaK2zbS8wlsQSIZLhvbUNadoKWs64NZqU30a1N3OpgnN5_hDhoE7PrRtACc9IZ1naKC96YVoqGy76FhmHMrDJF6_OstZna0mwHPkczPhF9WvHuRg_hVjeybIDiIvDxXiCG3xOkrNcudTCOxkOYkqa8KWNvFlgV6Idn0FWYoi-j2qGkXCjKd6j3jx39s_KwtQKQM6CLIaUIve5c3u-oGHSjJljvMqLnjOiSEb3PiN5p02fUB_UXSWwmpQL2A8T_tl9g3QHCwM3W
CitedBy_id crossref_primary_10_1017_S0033291723000107
crossref_primary_10_1016_j_jad_2024_09_112
crossref_primary_10_1002_hbm_25747
Cites_doi 10.1017/S0033291706008968
10.1016/j.jclinepi.2004.12.008
10.1038/s41386-019-0485-6
10.1016/j.neuroimage.2015.07.067
10.1080/10401230802177722
10.1016/j.neubiorev.2010.10.001
10.1016/j.biopsych.2008.07.026
10.3109/07853890.2011.595733
10.3389/fnins.2018.00842
10.1016/j.neuroimage.2013.05.012
10.1038/mp.2017.92
10.1016/j.neuroimage.2011.09.015
10.1017/S0033291706009743
10.1111/bdi.12465
10.1016/j.neuroimage.2013.05.057
10.1016/S0165-0327(02)00327-0
10.1016/j.euroneuro.2018.01.001
10.1111/j.1600-0447.2007.01066.x
10.1007/s00406-009-0002-8
10.2217/iim.13.49
10.1016/j.jad.2010.05.026
10.3389/fninf.2011.00023
10.1016/j.neulet.2014.06.061
10.1111/j.1399-5618.2011.00938.x
10.1016/j.neuroimage.2009.06.039
10.1016/j.biopsych.2010.07.028
10.1016/j.neuroimage.2013.05.041
10.1136/bmj.305.6846.160
10.1017/S0033291714000440
10.1038/mp.2012.188
10.1038/s41598-018-20295-3
10.1016/j.neuroimage.2012.02.084
10.1016/j.biopsych.2010.04.036
10.1001/archpsyc.65.9.1041
10.1016/j.biopsych.2010.09.027
10.1016/j.pnpbp.2018.03.022
10.1016/j.nicl.2018.101649
10.1016/j.jad.2015.02.004
10.1111/j.2044-8341.1959.tb00467.x
10.1002/hbm.22493
10.1016/j.neuroimage.2012.06.081
10.1016/j.jad.2020.09.133
10.1016/j.jad.2008.05.006
10.1111/bdi.12446
10.1111/j.1528-1167.2005.463003.x
10.1503/jpn.150341
10.1192/bjp.2018.101
10.1371/journal.pone.0059108
10.1016/j.eurpsy.2014.06.005
10.1176/appi.ajp.2013.12111462
10.1186/1471-244X-12-138
10.3389/fneur.2018.00092
10.1176/appi.ajp.163.2.322
10.1111/j.1399-5618.2012.01023.x
10.1111/bdi.12385
10.1016/j.physbeh.2011.10.029
10.1192/bjp.133.5.429
10.1176/appi.ajp.161.1.163
10.1192/bjp.134.4.382
10.1038/npp.2010.199
ContentType Journal Article
Copyright The Author(s) 2021
The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2021
– notice: The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
NPM
3V.
7X7
7XB
88A
88E
88I
8FE
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M2P
M7P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOA
DOI 10.1038/s41598-021-81355-9
DatabaseName Springer Nature OA Free Journals (Freely Accessible)
CrossRef
PubMed
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
Science Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Journals
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability (subscription)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection (subscription)
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection (UHCL Subscription)
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Science Database (subscription)
Biological Science Database
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database (subscription)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
PubMed
Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Science Journals
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList CrossRef

Publicly Available Content Database

MEDLINE - Academic

PubMed
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals (Freely Accessible)
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2045-2322
EndPage 10
ExternalDocumentID oai_doaj_org_article_5041ca3bc94547ab85748fbe73003d9a
PMC7815920
33469064
10_1038_s41598_021_81355_9
Genre Journal Article
GrantInformation_xml – fundername: Research Grants Council, University Grants Committee
  grantid: 24100114
  funderid: http://dx.doi.org/10.13039/501100002920
– fundername: Research Grants Council, University Grants Committee
  grantid: 24100114
– fundername: ;
  grantid: 24100114
GroupedDBID 0R~
3V.
4.4
53G
5VS
7X7
88A
88E
88I
8FE
8FH
8FI
8FJ
AAFWJ
AAJSJ
AAKDD
ABDBF
ABUWG
ACGFS
ACSMW
ACUHS
ADBBV
ADRAZ
AENEX
AEUYN
AFKRA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
DWQXO
EBD
EBLON
EBS
ESX
FYUFA
GNUQQ
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
KQ8
LK8
M0L
M1P
M2P
M48
M7P
M~E
NAO
OK1
PIMPY
PQQKQ
PROAC
PSQYO
RNT
RNTTT
RPM
SNYQT
UKHRP
AASML
AAYXX
AFPKN
CITATION
PHGZM
PHGZT
NPM
7XB
8FK
AARCD
K9.
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
Q9U
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c588t-537175a39d915225df21d2d4513ef13575a59d32dd5dbf80481d1e1830fbd71b3
IEDL.DBID 7X7
ISSN 2045-2322
IngestDate Wed Aug 27 01:08:47 EDT 2025
Thu Aug 21 18:21:24 EDT 2025
Fri Jul 11 17:03:25 EDT 2025
Wed Aug 13 05:16:11 EDT 2025
Thu Jan 02 22:57:49 EST 2025
Thu Apr 24 22:55:37 EDT 2025
Tue Jul 01 01:07:16 EDT 2025
Fri Feb 21 02:39:37 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c588t-537175a39d915225df21d2d4513ef13575a59d32dd5dbf80481d1e1830fbd71b3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
OpenAccessLink https://www.proquest.com/docview/2478869249?pq-origsite=%requestingapplication%
PMID 33469064
PQID 2478869249
PQPubID 2041939
PageCount 10
ParticipantIDs doaj_primary_oai_doaj_org_article_5041ca3bc94547ab85748fbe73003d9a
pubmedcentral_primary_oai_pubmedcentral_nih_gov_7815920
proquest_miscellaneous_2479417609
proquest_journals_2478869249
pubmed_primary_33469064
crossref_citationtrail_10_1038_s41598_021_81355_9
crossref_primary_10_1038_s41598_021_81355_9
springer_journals_10_1038_s41598_021_81355_9
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2021-01-19
PublicationDateYYYYMMDD 2021-01-19
PublicationDate_xml – month: 01
  year: 2021
  text: 2021-01-19
  day: 19
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Scientific reports
PublicationTitleAbbrev Sci Rep
PublicationTitleAlternate Sci Rep
PublicationYear 2021
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Berk (CR16) 2011; 35
Yendiki, Panneck, Srinivasan, Stevens, Zöllei, Augustinack, Wang, Salat, Ehrlich, Behrens, Jbabdi, Gollub, Fischl (CR42) 2011; 5
Atmaca, Yildirim, Ozdemir, Ogur, Tezcan (CR28) 2007; 37
Abramovic (CR17) 2018; 28
Jiang (CR23) 2021; 279
CR38
Jones, Knosche, Turner (CR41) 2013; 73
Jenkinson, Bechmann, Behrens, Woolrich, Smith (CR61) 2012; 62
Madhyastha, Mérillat, Hirsiger, Bezzola, Liem, Grabowski, Jäncke (CR45) 2014; 35
Atmaca, Ozdemir, Yildirim (CR22) 2007; 37
Benazzi, Akiskal (CR51) 2003; 73
Hafeman, Chang, Garrett, Sanders, Phillips (CR26) 2012; 14
Lagopoulos (CR9) 2013; 8
Aiken, Weisler, Sachs (CR39) 2015; 177
Sole (CR3) 2016; 18
CR4
Tondo, Lepri, Baldessarini (CR5) 2007; 116
Adler (CR31) 2006; 163
Benedetti (CR7) 2011; 13
Benedetti (CR29) 2011; 69
Andersson, Sotiropoulos (CR50) 2015; 122
Wechsler (CR59) 1987
Aung, Mar, Benzinger (CR35) 2013; 5
Ugurbil (CR47) 2013; 80
Mak (CR21) 2018; 8
Teixeira (CR30) 2014; 579
Savitz (CR24) 2011; 69
Lam, Tse, Gandek, Fong (CR58) 2005; 58
McIntosh (CR8) 2008; 64
Reuter, Schmansky, Rosas, Fischl (CR62) 2012; 61
Versace (CR10) 2010; 68
Shi, Toga (CR49) 2017; 22
Favre (CR18) 2019; 44
Borgwardt, Fusar-Poli (CR15) 2012; 12
Chan, Chen, Chan (CR60) 2005; 15
Yin (CR34) 2018; 12
Repple (CR12) 2017; 19
Mak (CR52) 2009; 112
Sotiropoulos (CR48) 2013; 80
CR55
Liu (CR13) 2010; 127
Rive (CR25) 2016; 18
CR54
Gunde, Blagdon, Hajek (CR43) 2011; 43
Lai, Wu (CR36) 2014; 44
Fiedorowicz, Palagummi, Forman-Hoffman, Miller, Haynes (CR44) 2008; 20
Sprooten (CR6) 2013; 170
So, Kam, Leung, Chung, Liu, Fong (CR53) 2003; 13
Bauer, Pfennig (CR1) 2005; 46
Han, De Berardis, Fornaro, Kim (CR11) 2019; 91
Mamah, Ji, Rutlin, Shimony (CR19) 2019; 21
Grande, Magalhaes, Kunz, Vieta, Kapczinski (CR32) 2012; 106
Jiang (CR40) 2017; 42
Van Essen (CR46) 2013; 80
Dervic (CR2) 2015; 30
Versace (CR20) 2014; 19
Foley (CR14) 2018; 213
Hamilton (CR56) 1959; 32
Winklewski (CR37) 2018
Brazier, Harper, Jones, O’Cathain, Thomas, Usherwood, Westlake (CR57) 1992; 305
CR64
Zanetti (CR33) 2009; 259
Versace (CR27) 2008; 65
Zheng, Chee, Zagorodnov (CR63) 2009; 48
M Bauer (81355_CR1) 2005; 46
CM Adler (81355_CR31) 2006; 163
WY Aung (81355_CR35) 2013; 5
81355_CR54
JX Liu (81355_CR13) 2010; 127
I Grande (81355_CR32) 2012; 106
DC Van Essen (81355_CR46) 2013; 80
L Tondo (81355_CR5) 2007; 116
M Atmaca (81355_CR22) 2007; 37
A Yendiki (81355_CR42) 2011; 5
M Berk (81355_CR16) 2011; 35
81355_CR55
J Lagopoulos (81355_CR9) 2013; 8
Z Yin (81355_CR34) 2018; 12
81355_CR4
P Favre (81355_CR18) 2019; 44
E Sprooten (81355_CR6) 2013; 170
W Zheng (81355_CR63) 2009; 48
JE Brazier (81355_CR57) 1992; 305
D Mamah (81355_CR19) 2019; 21
MV Zanetti (81355_CR33) 2009; 259
SF Foley (81355_CR14) 2018; 213
AM Teixeira (81355_CR30) 2014; 579
A Versace (81355_CR10) 2010; 68
M Hamilton (81355_CR56) 1959; 32
JG Fiedorowicz (81355_CR44) 2008; 20
SN Sotiropoulos (81355_CR48) 2013; 80
L Abramovic (81355_CR17) 2018; 28
F Benedetti (81355_CR29) 2011; 69
CB Aiken (81355_CR39) 2015; 177
M Reuter (81355_CR62) 2012; 61
MM Rive (81355_CR25) 2016; 18
J Jiang (81355_CR40) 2017; 42
DK Jones (81355_CR41) 2013; 73
F Benazzi (81355_CR51) 2003; 73
A Versace (81355_CR20) 2014; 19
81355_CR38
A Versace (81355_CR27) 2008; 65
PJ Winklewski (81355_CR37) 2018
JB Savitz (81355_CR24) 2011; 69
E So (81355_CR53) 2003; 13
ELS Chan (81355_CR60) 2005; 15
DM Hafeman (81355_CR26) 2012; 14
KM Han (81355_CR11) 2019; 91
K Dervic (81355_CR2) 2015; 30
F Benedetti (81355_CR7) 2011; 13
T Madhyastha (81355_CR45) 2014; 35
D Wechsler (81355_CR59) 1987
B Sole (81355_CR3) 2016; 18
S Borgwardt (81355_CR15) 2012; 12
K Ugurbil (81355_CR47) 2013; 80
AM McIntosh (81355_CR8) 2008; 64
X Jiang (81355_CR23) 2021; 279
Y Shi (81355_CR49) 2017; 22
J Repple (81355_CR12) 2017; 19
81355_CR64
CH Lai (81355_CR36) 2014; 44
M Atmaca (81355_CR28) 2007; 37
ADP Mak (81355_CR52) 2009; 112
ADP Mak (81355_CR21) 2018; 8
CL Lam (81355_CR58) 2005; 58
E Gunde (81355_CR43) 2011; 43
M Jenkinson (81355_CR61) 2012; 62
JLR Andersson (81355_CR50) 2015; 122
References_xml – volume: 37
  start-page: 121
  year: 2007
  end-page: 129
  ident: CR28
  article-title: Hippocampal 1H MRS in patients with bipolar disorder taking valproate versus valproate plus quetiapine
  publication-title: Psychol. Med.
  doi: 10.1017/S0033291706008968
– volume: 58
  start-page: 815
  year: 2005
  end-page: 822
  ident: CR58
  article-title: The SF-36 summary scales were valid, reliable, and equivalent in a Chinese population
  publication-title: J. Clin. Epidemiol.
  doi: 10.1016/j.jclinepi.2004.12.008
– volume: 44
  start-page: 2285
  year: 2019
  end-page: 2293
  ident: CR18
  article-title: Widespread white matter microstructural abnormalities in bipolar disorder: Evidence from mega- and meta-analyses across 3033 individuals
  publication-title: Neuropsychopharmacology
  doi: 10.1038/s41386-019-0485-6
– ident: CR4
– volume: 13
  start-page: 7
  year: 2003
  end-page: 18
  ident: CR53
  article-title: The Chinese-bilingual SCID-I/P Project: Stage 1—Reliability for mood disorders and schizophrenia
  publication-title: Hong Kong J. Psychiatry
– volume: 122
  start-page: 166
  year: 2015
  end-page: 176
  ident: CR50
  article-title: Non-parametric representation and prediction of single- and multi-shell diffusion-weighted MRI data using Gaussian processes
  publication-title: NeuroImage
  doi: 10.1016/j.neuroimage.2015.07.067
– volume: 20
  start-page: 131
  year: 2008
  end-page: 137
  ident: CR44
  article-title: Elevated prevalence of obesity, metabolic syndrome, and cardiovascular risk factors in bipolar disorder
  publication-title: Ann. Clin. Psychiatry
  doi: 10.1080/10401230802177722
– volume: 35
  start-page: 804
  year: 2011
  end-page: 817
  ident: CR16
  article-title: Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors
  publication-title: Neurosci. Biobehav. Rev.
  doi: 10.1016/j.neubiorev.2010.10.001
– volume: 64
  start-page: 1088
  year: 2008
  end-page: 1092
  ident: CR8
  article-title: White matter tractography in bipolar disorder and schizophrenia
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2008.07.026
– volume: 43
  start-page: 571
  year: 2011
  end-page: 580
  ident: CR43
  article-title: White matter hyperintensities: From medical comorbidities to bipolar disorders and back
  publication-title: Ann. Med.
  doi: 10.3109/07853890.2011.595733
– ident: CR54
– volume: 12
  start-page: 842
  year: 2018
  ident: CR34
  article-title: Decreased functional connectivity in insular subregions in depressive episodes of bipolar disorder and major depressive disorder
  publication-title: Front. Neurosci.
  doi: 10.3389/fnins.2018.00842
– volume: 80
  start-page: 80
  year: 2013
  end-page: 104
  ident: CR47
  article-title: Pushing spatial and temporal resolution for functional and diffusion MRI in the Human Connectome Project
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2013.05.012
– volume: 22
  start-page: 1230
  year: 2017
  end-page: 1240
  ident: CR49
  article-title: Connectome imaging for mapping human brain pathways
  publication-title: Mol. Psychiatry
  doi: 10.1038/mp.2017.92
– volume: 62
  start-page: 782
  year: 2012
  end-page: 790
  ident: CR61
  article-title: FSL
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2011.09.015
– volume: 37
  start-page: 699
  year: 2007
  end-page: 704
  ident: CR22
  article-title: Corpus callosum areas in first-episode patients with bipolar disorder
  publication-title: Psychol. Med.
  doi: 10.1017/S0033291706009743
– volume: 19
  start-page: 23
  year: 2017
  end-page: 31
  ident: CR12
  article-title: A voxel-based diffusion tensor imaging study in unipolar and bipolar depression
  publication-title: Bipolar Disord.
  doi: 10.1111/bdi.12465
– volume: 80
  start-page: 125
  year: 2013
  end-page: 143
  ident: CR48
  article-title: Advances in diffusion MRI acquisition and processing in the Human Connectome Project
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2013.05.057
– volume: 73
  start-page: 33
  year: 2003
  end-page: 38
  ident: CR51
  article-title: Refining the evaluation of bipolar II: Beyond the strict SCID-CV guidelines for hypomania
  publication-title: J. Affect. Disord.
  doi: 10.1016/S0165-0327(02)00327-0
– volume: 28
  start-page: 743
  year: 2018
  end-page: 751
  ident: CR17
  article-title: White matter disruptions in patients with bipolar disorder
  publication-title: Eur. Neuropsychopharmacol.
  doi: 10.1016/j.euroneuro.2018.01.001
– volume: 15
  start-page: 39
  year: 2005
  end-page: 42
  ident: CR60
  article-title: Three-subtest short form of the wechsler adult intelligence scale-III for patients with psychotic disorders: A preliminary report
  publication-title: Hong Kong J. Psychiatry
– volume: 116
  start-page: 419
  year: 2007
  end-page: 428
  ident: CR5
  article-title: Suicidal risks among 2826 Sardinian major affective disorder patients
  publication-title: Acta Psychiatr. Scand.
  doi: 10.1111/j.1600-0447.2007.01066.x
– volume: 259
  start-page: 316
  year: 2009
  end-page: 328
  ident: CR33
  article-title: State-dependent microstructural white matter changes in bipolar I depression
  publication-title: Eur. Arch. Psychiatry Clin. Neurosci.
  doi: 10.1007/s00406-009-0002-8
– volume: 5
  start-page: 427
  year: 2013
  end-page: 440
  ident: CR35
  article-title: Diffusion tensor MRI as a biomarker in axonal and myelin damage
  publication-title: Imaging Med.
  doi: 10.2217/iim.13.49
– volume: 127
  start-page: 309
  year: 2010
  end-page: 315
  ident: CR13
  article-title: Differences in white matter abnormalities between bipolar I and II disorders
  publication-title: J. Affect Disord.
  doi: 10.1016/j.jad.2010.05.026
– volume: 5
  start-page: 23
  year: 2011
  ident: CR42
  article-title: Automated probabilistic reconstruction of white-matter pathways in health and disease using an atlas of the underlying anatomy
  publication-title: Front. Neuroinform.
  doi: 10.3389/fninf.2011.00023
– volume: 579
  start-page: 41
  year: 2014
  end-page: 45
  ident: CR30
  article-title: Preserved white matter in unmedicated pediatric bipolar disorder
  publication-title: Neurosci. Lett.
  doi: 10.1016/j.neulet.2014.06.061
– year: 1987
  ident: CR59
  publication-title: Wechsler Memory Scale-Revised Manual
– volume: 13
  start-page: 414
  year: 2011
  end-page: 424
  ident: CR7
  article-title: Tract-specific white matter structural disruption in patients with bipolar disorder
  publication-title: Bipolar Disord.
  doi: 10.1111/j.1399-5618.2011.00938.x
– ident: CR64
– volume: 48
  start-page: 73
  year: 2009
  end-page: 83
  ident: CR63
  article-title: Improvement of brain segmentation accuracy by optimizing non-uniformity correction using N3
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2009.06.039
– volume: 69
  start-page: 309
  year: 2011
  end-page: 317
  ident: CR29
  article-title: Disruption of white matter integrity in bipolar depression as a possible structural marker of illness
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2010.07.028
– volume: 80
  start-page: 62
  year: 2013
  end-page: 79
  ident: CR46
  article-title: The WU-Minn human connectome project: An overview
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2013.05.041
– volume: 305
  start-page: 160
  year: 1992
  end-page: 164
  ident: CR57
  article-title: Validating the SF-36 health survey questionnaire: New outcome measure for primary care
  publication-title: BMJ
  doi: 10.1136/bmj.305.6846.160
– volume: 44
  start-page: 2825
  year: 2014
  end-page: 2832
  ident: CR36
  article-title: Alterations in white matter micro-integrity of the superior longitudinal fasciculus and anterior thalamic radiation of young adult patients with depression
  publication-title: Psychol. Med.
  doi: 10.1017/S0033291714000440
– volume: 19
  start-page: 200
  year: 2014
  end-page: 208
  ident: CR20
  article-title: Elevated serum measures of lipid peroxidation and abnormal prefrontal white matter in euthymic bipolar adults: Toward peripheral biomarkers of bipolar disorder
  publication-title: Mol. Psychiatry
  doi: 10.1038/mp.2012.188
– volume: 8
  start-page: 1905
  year: 2018
  ident: CR21
  article-title: Cognitive impairment in treatment-naive bipolar II and unipolar depression
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-20295-3
– volume: 61
  start-page: 1402
  year: 2012
  end-page: 1418
  ident: CR62
  article-title: Within-subject template estimation for unbiased longitudinal image analysis
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2012.02.084
– volume: 68
  start-page: 560
  year: 2010
  end-page: 567
  ident: CR10
  article-title: Right orbitofrontal corticolimbic and left corticocortical white matter connectivity differentiate bipolar and unipolar depression
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2010.04.036
– volume: 65
  start-page: 1041
  year: 2008
  end-page: 1052
  ident: CR27
  article-title: Elevated left and reduced right orbitomedial prefrontal fractional anisotropy in adults with bipolar disorder revealed by tract-based spatial statistics
  publication-title: Arch. Gen. Psychiatry
  doi: 10.1001/archpsyc.65.9.1041
– volume: 69
  start-page: 336
  year: 2011
  end-page: 343
  ident: CR24
  article-title: Habenula volume in bipolar disorder and major depressive disorder: A high-resolution magnetic resonance imaging study
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2010.09.027
– volume: 91
  start-page: 20
  year: 2019
  end-page: 27
  ident: CR11
  article-title: Differentiating between bipolar and unipolar depression in functional and structural MRI studies
  publication-title: Prog. Neuropsychopharmacol. Biol. Psychiatry
  doi: 10.1016/j.pnpbp.2018.03.022
– volume: 21
  start-page: 101649
  year: 2019
  ident: CR19
  article-title: White matter integrity in schizophrenia and bipolar disorder: Tract- and voxel-based analyses of diffusion data from the Connectom scanner
  publication-title: Neuroimage Clin.
  doi: 10.1016/j.nicl.2018.101649
– volume: 177
  start-page: 59
  year: 2015
  end-page: 64
  ident: CR39
  article-title: The Bipolarity Index: A clinician-rated measure of diagnostic confidence
  publication-title: J. Affect. Disord.
  doi: 10.1016/j.jad.2015.02.004
– volume: 32
  start-page: 50
  year: 1959
  end-page: 55
  ident: CR56
  article-title: The assessment of anxiety states by rating
  publication-title: Br. J. Med. Psychol.
  doi: 10.1111/j.2044-8341.1959.tb00467.x
– volume: 35
  start-page: 4544
  year: 2014
  end-page: 4555
  ident: CR45
  article-title: Longitudinal reliability of tract-based spatial statistics in diffusion tensor imaging
  publication-title: Hum. Brain Mapp.
  doi: 10.1002/hbm.22493
– volume: 73
  start-page: 239
  year: 2013
  end-page: 254
  ident: CR41
  article-title: White matter integrity, fiber count, and other fallacies: The do's and don'ts of diffusion MRI
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2012.06.081
– volume: 279
  start-page: 324
  year: 2021
  end-page: 333
  ident: CR23
  article-title: Structural and functional alterations in untreated patients with major depressive disorder and bipolar disorder experiencing first depressive episode: A magnetic resonance imaging study combined with follow-up
  publication-title: J. Affect Disord.
  doi: 10.1016/j.jad.2020.09.133
– volume: 112
  start-page: 201
  year: 2009
  end-page: 205
  ident: CR52
  article-title: Prevalence and correlates of bipolar II disorder in major depressive patients at a psychiatric outpatient clinic in Hong Kong
  publication-title: J. Affect. Disord.
  doi: 10.1016/j.jad.2008.05.006
– volume: 18
  start-page: 612
  year: 2016
  end-page: 623
  ident: CR25
  article-title: Distinguishing medication-free subjects with unipolar disorder from subjects with bipolar disorder: state matters
  publication-title: Bipolar Disord.
  doi: 10.1111/bdi.12446
– volume: 46
  start-page: 8
  year: 2005
  end-page: 13
  ident: CR1
  article-title: Epidemiology of bipolar disorders
  publication-title: Epilepsia
  doi: 10.1111/j.1528-1167.2005.463003.x
– ident: CR38
– volume: 42
  start-page: 150
  year: 2017
  end-page: 163
  ident: CR40
  article-title: Microstructural brain abnormalities in medication-free patients with major depressive disorder: A systematic review and meta-analysis of diffusion tensor imaging
  publication-title: J. Psychiatry Neurosci. JPN
  doi: 10.1503/jpn.150341
– volume: 213
  start-page: 548
  year: 2018
  end-page: 554
  ident: CR14
  article-title: Fractional anisotropy of the uncinate fasciculus and cingulum in bipolar disorder type I, type II, unaffected siblings and healthy controls
  publication-title: Br. J. Psychiatry
  doi: 10.1192/bjp.2018.101
– volume: 8
  start-page: e59108
  year: 2013
  ident: CR9
  article-title: Microstructural white matter changes in the corpus callosum of young people with Bipolar Disorder: A diffusion tensor imaging study
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0059108
– ident: CR55
– volume: 30
  start-page: 106
  year: 2015
  end-page: 113
  ident: CR2
  article-title: Bipolar I and II versus unipolar depression: Clinical differences and impulsivity/aggression traits
  publication-title: Eur. Psychiatry
  doi: 10.1016/j.eurpsy.2014.06.005
– volume: 170
  start-page: 1317
  year: 2013
  end-page: 1325
  ident: CR6
  article-title: Reduced white matter integrity in sibling pairs discordant for bipolar disorder
  publication-title: Am. J. Psychiatry
  doi: 10.1176/appi.ajp.2013.12111462
– volume: 12
  start-page: 138
  year: 2012
  ident: CR15
  article-title: White matter pathology—An endophenotype for bipolar disorder?
  publication-title: BMC Psychiatry
  doi: 10.1186/1471-244X-12-138
– year: 2018
  ident: CR37
  article-title: Understanding the physiopathology behind axial and radial diffusivity changes—What do we know?
  publication-title: Front. Neurol.
  doi: 10.3389/fneur.2018.00092
– volume: 163
  start-page: 322
  year: 2006
  end-page: 324
  ident: CR31
  article-title: Evidence of white matter pathology in bipolar disorder adolescents experiencing their first episode of mania: A diffusion tensor imaging study
  publication-title: Am. J. Psychiatry
  doi: 10.1176/appi.ajp.163.2.322
– volume: 14
  start-page: 375
  year: 2012
  end-page: 410
  ident: CR26
  article-title: Effects of medication on neuroimaging findings in bipolar disorder: An updated review
  publication-title: Bipolar Disord.
  doi: 10.1111/j.1399-5618.2012.01023.x
– volume: 18
  start-page: 288
  year: 2016
  end-page: 299
  ident: CR3
  article-title: Cognitive variability in bipolar II disorder: Who is cognitively impaired and who is preserved
  publication-title: Bipolar Disord.
  doi: 10.1111/bdi.12385
– volume: 106
  start-page: 46
  year: 2012
  end-page: 50
  ident: CR32
  article-title: Mediators of allostasis and systemic toxicity in bipolar disorder
  publication-title: Physiol. Behav.
  doi: 10.1016/j.physbeh.2011.10.029
– volume: 35
  start-page: 804
  year: 2011
  ident: 81355_CR16
  publication-title: Neurosci. Biobehav. Rev.
  doi: 10.1016/j.neubiorev.2010.10.001
– volume: 177
  start-page: 59
  year: 2015
  ident: 81355_CR39
  publication-title: J. Affect. Disord.
  doi: 10.1016/j.jad.2015.02.004
– volume: 80
  start-page: 80
  year: 2013
  ident: 81355_CR47
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2013.05.012
– volume: 22
  start-page: 1230
  year: 2017
  ident: 81355_CR49
  publication-title: Mol. Psychiatry
  doi: 10.1038/mp.2017.92
– volume: 259
  start-page: 316
  year: 2009
  ident: 81355_CR33
  publication-title: Eur. Arch. Psychiatry Clin. Neurosci.
  doi: 10.1007/s00406-009-0002-8
– volume: 20
  start-page: 131
  year: 2008
  ident: 81355_CR44
  publication-title: Ann. Clin. Psychiatry
  doi: 10.1080/10401230802177722
– volume: 68
  start-page: 560
  year: 2010
  ident: 81355_CR10
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2010.04.036
– volume: 80
  start-page: 62
  year: 2013
  ident: 81355_CR46
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2013.05.041
– volume: 15
  start-page: 39
  year: 2005
  ident: 81355_CR60
  publication-title: Hong Kong J. Psychiatry
– volume: 19
  start-page: 23
  year: 2017
  ident: 81355_CR12
  publication-title: Bipolar Disord.
  doi: 10.1111/bdi.12465
– ident: 81355_CR55
  doi: 10.1192/bjp.133.5.429
– volume: 213
  start-page: 548
  year: 2018
  ident: 81355_CR14
  publication-title: Br. J. Psychiatry
  doi: 10.1192/bjp.2018.101
– volume: 28
  start-page: 743
  year: 2018
  ident: 81355_CR17
  publication-title: Eur. Neuropsychopharmacol.
  doi: 10.1016/j.euroneuro.2018.01.001
– volume: 44
  start-page: 2825
  year: 2014
  ident: 81355_CR36
  publication-title: Psychol. Med.
  doi: 10.1017/S0033291714000440
– volume: 21
  start-page: 101649
  year: 2019
  ident: 81355_CR19
  publication-title: Neuroimage Clin.
  doi: 10.1016/j.nicl.2018.101649
– volume: 48
  start-page: 73
  year: 2009
  ident: 81355_CR63
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2009.06.039
– volume: 64
  start-page: 1088
  year: 2008
  ident: 81355_CR8
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2008.07.026
– volume: 579
  start-page: 41
  year: 2014
  ident: 81355_CR30
  publication-title: Neurosci. Lett.
  doi: 10.1016/j.neulet.2014.06.061
– volume: 8
  start-page: e59108
  year: 2013
  ident: 81355_CR9
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0059108
– volume: 18
  start-page: 612
  year: 2016
  ident: 81355_CR25
  publication-title: Bipolar Disord.
  doi: 10.1111/bdi.12446
– volume: 35
  start-page: 4544
  year: 2014
  ident: 81355_CR45
  publication-title: Hum. Brain Mapp.
  doi: 10.1002/hbm.22493
– volume: 32
  start-page: 50
  year: 1959
  ident: 81355_CR56
  publication-title: Br. J. Med. Psychol.
  doi: 10.1111/j.2044-8341.1959.tb00467.x
– volume: 8
  start-page: 1905
  year: 2018
  ident: 81355_CR21
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-20295-3
– volume: 43
  start-page: 571
  year: 2011
  ident: 81355_CR43
  publication-title: Ann. Med.
  doi: 10.3109/07853890.2011.595733
– volume: 62
  start-page: 782
  year: 2012
  ident: 81355_CR61
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2011.09.015
– volume: 279
  start-page: 324
  year: 2021
  ident: 81355_CR23
  publication-title: J. Affect Disord.
  doi: 10.1016/j.jad.2020.09.133
– volume: 44
  start-page: 2285
  year: 2019
  ident: 81355_CR18
  publication-title: Neuropsychopharmacology
  doi: 10.1038/s41386-019-0485-6
– volume: 65
  start-page: 1041
  year: 2008
  ident: 81355_CR27
  publication-title: Arch. Gen. Psychiatry
  doi: 10.1001/archpsyc.65.9.1041
– volume: 5
  start-page: 427
  year: 2013
  ident: 81355_CR35
  publication-title: Imaging Med.
  doi: 10.2217/iim.13.49
– volume: 305
  start-page: 160
  year: 1992
  ident: 81355_CR57
  publication-title: BMJ
  doi: 10.1136/bmj.305.6846.160
– volume: 42
  start-page: 150
  year: 2017
  ident: 81355_CR40
  publication-title: J. Psychiatry Neurosci. JPN
  doi: 10.1503/jpn.150341
– volume: 112
  start-page: 201
  year: 2009
  ident: 81355_CR52
  publication-title: J. Affect. Disord.
  doi: 10.1016/j.jad.2008.05.006
– volume-title: Wechsler Memory Scale-Revised Manual
  year: 1987
  ident: 81355_CR59
– volume: 46
  start-page: 8
  year: 2005
  ident: 81355_CR1
  publication-title: Epilepsia
  doi: 10.1111/j.1528-1167.2005.463003.x
– volume: 5
  start-page: 23
  year: 2011
  ident: 81355_CR42
  publication-title: Front. Neuroinform.
  doi: 10.3389/fninf.2011.00023
– volume: 69
  start-page: 336
  year: 2011
  ident: 81355_CR24
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2010.09.027
– volume: 14
  start-page: 375
  year: 2012
  ident: 81355_CR26
  publication-title: Bipolar Disord.
  doi: 10.1111/j.1399-5618.2012.01023.x
– ident: 81355_CR4
  doi: 10.1176/appi.ajp.161.1.163
– volume: 12
  start-page: 138
  year: 2012
  ident: 81355_CR15
  publication-title: BMC Psychiatry
  doi: 10.1186/1471-244X-12-138
– volume: 18
  start-page: 288
  year: 2016
  ident: 81355_CR3
  publication-title: Bipolar Disord.
  doi: 10.1111/bdi.12385
– volume: 91
  start-page: 20
  year: 2019
  ident: 81355_CR11
  publication-title: Prog. Neuropsychopharmacol. Biol. Psychiatry
  doi: 10.1016/j.pnpbp.2018.03.022
– volume: 37
  start-page: 699
  year: 2007
  ident: 81355_CR22
  publication-title: Psychol. Med.
  doi: 10.1017/S0033291706009743
– volume: 13
  start-page: 7
  year: 2003
  ident: 81355_CR53
  publication-title: Hong Kong J. Psychiatry
– volume: 61
  start-page: 1402
  year: 2012
  ident: 81355_CR62
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2012.02.084
– volume: 19
  start-page: 200
  year: 2014
  ident: 81355_CR20
  publication-title: Mol. Psychiatry
  doi: 10.1038/mp.2012.188
– volume: 116
  start-page: 419
  year: 2007
  ident: 81355_CR5
  publication-title: Acta Psychiatr. Scand.
  doi: 10.1111/j.1600-0447.2007.01066.x
– volume: 106
  start-page: 46
  year: 2012
  ident: 81355_CR32
  publication-title: Physiol. Behav.
  doi: 10.1016/j.physbeh.2011.10.029
– ident: 81355_CR64
– volume: 37
  start-page: 121
  year: 2007
  ident: 81355_CR28
  publication-title: Psychol. Med.
  doi: 10.1017/S0033291706008968
– ident: 81355_CR54
  doi: 10.1192/bjp.134.4.382
– volume: 73
  start-page: 239
  year: 2013
  ident: 81355_CR41
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2012.06.081
– volume: 12
  start-page: 842
  year: 2018
  ident: 81355_CR34
  publication-title: Front. Neurosci.
  doi: 10.3389/fnins.2018.00842
– ident: 81355_CR38
  doi: 10.1038/npp.2010.199
– year: 2018
  ident: 81355_CR37
  publication-title: Front. Neurol.
  doi: 10.3389/fneur.2018.00092
– volume: 13
  start-page: 414
  year: 2011
  ident: 81355_CR7
  publication-title: Bipolar Disord.
  doi: 10.1111/j.1399-5618.2011.00938.x
– volume: 69
  start-page: 309
  year: 2011
  ident: 81355_CR29
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2010.07.028
– volume: 122
  start-page: 166
  year: 2015
  ident: 81355_CR50
  publication-title: NeuroImage
  doi: 10.1016/j.neuroimage.2015.07.067
– volume: 170
  start-page: 1317
  year: 2013
  ident: 81355_CR6
  publication-title: Am. J. Psychiatry
  doi: 10.1176/appi.ajp.2013.12111462
– volume: 163
  start-page: 322
  year: 2006
  ident: 81355_CR31
  publication-title: Am. J. Psychiatry
  doi: 10.1176/appi.ajp.163.2.322
– volume: 30
  start-page: 106
  year: 2015
  ident: 81355_CR2
  publication-title: Eur. Psychiatry
  doi: 10.1016/j.eurpsy.2014.06.005
– volume: 58
  start-page: 815
  year: 2005
  ident: 81355_CR58
  publication-title: J. Clin. Epidemiol.
  doi: 10.1016/j.jclinepi.2004.12.008
– volume: 80
  start-page: 125
  year: 2013
  ident: 81355_CR48
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2013.05.057
– volume: 73
  start-page: 33
  year: 2003
  ident: 81355_CR51
  publication-title: J. Affect. Disord.
  doi: 10.1016/S0165-0327(02)00327-0
– volume: 127
  start-page: 309
  year: 2010
  ident: 81355_CR13
  publication-title: J. Affect Disord.
  doi: 10.1016/j.jad.2010.05.026
SSID ssj0000529419
Score 2.331049
Snippet It is unknown if young medication-naïve bipolar II (BPII) depressed patients have increased white matter (WM) disruptions. 27 each of young (average 23 years)...
It is unknown if young medication-naïve bipolar II (BPII) depressed patients have increased white matter (WM) disruptions. 27 each of young (average 23 years)...
Abstract It is unknown if young medication-naïve bipolar II (BPII) depressed patients have increased white matter (WM) disruptions. 27 each of young (average...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1816
SubjectTerms 692/699/476/1333
692/699/476/1414
Affective disorders
Discriminant analysis
Humanities and Social Sciences
Longitudinal studies
Magnetic resonance imaging
Mental depression
multidisciplinary
Patients
Principal components analysis
Science
Science (multidisciplinary)
Substantia alba
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1baxUxEB6kIPgi1utqlQi-aWgum03yqGJphfpkoW8h2SRY0G3pORX6q_wR_WNOkj3HHq8vvi3JBCaTGWZmJ_kG4AXLXsXERqqtxwTFBE59kInioM7GZ5lZee98-GHYP-rfH6vja62-yp2wBg_cBLerWM9HL8NoC_SUD0bp3uSQCs66jLaGRujzriVTDdVb2J7b-ZUMk2Z3gZ6qvCYTnBqOTpbaDU9UAft_F2X-elnyp4ppdUR7d-D2HEGS143zbbiRprtws_WUvLwHh7XlHflScTNJQ4PASBu_yGWxbFKr6fU86OSvvn1NJJyclQSXHByQ-WJsiqQCcyzuw9Heu49v9-ncM4GOypglVRLzM-WljRY9s1AxCx5F7BWXKeO-cU7ZKEWMKoZsClpM5AntmuUQNQ_yAWxNp1N6BETHgOYuR29G3w8-W-21GLMcPIYguLgDvpKfG2dA8dLX4rOrhW1pXJO5Q5m7KnNnO3i5XnPW4DT-Sv2mHMuaskBh1wFUEDcriPuXgnSwszpUN9vnwonSNWAouWcHz9fTaFmlXOKndHpRaVCH9MCQ5mHTgTUnUpbfCkPfgd7Qjg1WN2emk08VvVsb3KZgHbxa6dEPtv4sisf_QxRP4JYoBsA45XYHtpbnF-kpxlTL8Kyaz3fxnhzY
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1fb9QwDLfGEBIviP90DFQk3iDQJE2TPCAEiGlDOp44aW9R0iRs0uiNu9vEfSo-BF8MJ20PHRx7qxpHShy7tuv4Z4DnVbTCh6olUlsMUJSjxDoeCL6UUdnIY5XqnSefm8Np_elYHO_A2O5oYOBia2iX-klN52evfnxfvUWFf9OXjKvXCzRCqVCMUaIo2k-ir8F1tEwyKepkcPd7rG-ma6qH2pntUzfsU4bx3-Z7_nuF8q88ajZPB7fh1uBXlu96QbgDO6G7Czf6TpOrezDJjfDKbxlNs-wxItD_xqdylfS9zDn2fEqks79-XobSnZ4n3pRHR-VwXTb4MsN1LO7D9ODjlw-HZOikQFqh1JIIjlGbsFx7jfaaCR8Z9czXgvIQcd84JrTnzHvhXVQJQ8bTgNpeRecldfwB7HazLjyCUnqHHwHeWtXaurFRSytZG3lj0THByQXQkX-mHWDGU7eLM5PT3VyZnucGeW4yz40u4MV6znkPsnEl9ft0LGvKBJCdX8zmX82gb0ZUNW0td61OiGXWKSFrFV1I8Pzca1vA_nioZhQ6w1IvgSZFpAU8Ww-jvqUkiu3C7CLToAzJpkKah70MrFfCefrZ0NQFyA3p2Fjq5kh3epIxvaXCbbKqgJejHP1Z1v9ZsXf1Lh7DTZZEu6KE6n3YXc4vwhP0oZbuaVaM32iJF-8
  priority: 102
  providerName: Scholars Portal
– databaseName: Springer Nature OA Free Journals (Freely Accessible)
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3dahUxEB5qRfBG_He1lgjeaXCTbDbJpR4sbaFeWehdSDaJFnRP6TkV-lQ-hC_mJPsjR1uhd0sygWQyszPJZL4BeF0nJ0OsO6qMwwOK9ow6LyLFRpW0SyLVOd_56FO7f9wcnsiTLeBTLkx5tF8gLctvenod9m6FhiYng3FGNUMbSc0tuJ2h27NUL9rFfK-SI1cNM2N-TC30FUM3bFCB6r_Kv_z3meRfsdJigvbuw73RdyTvh9k-gK3YP4Q7QzXJy0dwVIrdke8FMZMMOBDoY-MXucw6TUocvewE7d2vnz8i8adn-WhLDg7I-CQ2BlIgOVaP4Xjv4-fFPh2rJdBOar2mUuDJTDphgkGbzGVInAUeGslETLhu7JMmCB6CDD7pjBMTWESNrpMPinnxBLb7ZR-fAVHBo6KLzunONa1LRjnFuyRah84HDq6ATfyz3QglnitafLMlpC20HXhukee28NyaCt7MY84GII3_Un_I2zJTZhDs0rA8_2JHobCybljnhO9MRiVzXkvV6ORjhuAXwbgKdqZNtaNmrizP9QLafOqs4NXcjTqVAyWuj8uLQoMypNoaaZ4OMjDPRIh8odA2FagN6diY6mZPf_q14HYrjcvkdQVvJzn6M63rWfH8ZuQv4C7Pol4zyswObK_PL-JL9JvWfrcoym8TnxKF
  priority: 102
  providerName: Springer Nature
Title White matter integrity in young medication-naïve bipolar II depressed adults
URI https://link.springer.com/article/10.1038/s41598-021-81355-9
https://www.ncbi.nlm.nih.gov/pubmed/33469064
https://www.proquest.com/docview/2478869249
https://www.proquest.com/docview/2479417609
https://pubmed.ncbi.nlm.nih.gov/PMC7815920
https://doaj.org/article/5041ca3bc94547ab85748fbe73003d9a
Volume 11
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1fb9MwELdgExIviP8ERhUk3sBaHMex_YS6atNWqRMCJvXNsmMbJkFa1g5pn4oPwRfjzkkzlT97SSLbkezzne98Z_-OkNdFtMKHoqFSW9igKMeodTxQKJRR2chjgfedZ6f18Vk1nYt573Bb9ccqN2tiWqj9okEf-X6JOO817hbeLb9TzBqF0dU-hcZtsovQZXikS87l4GPBKFbFdH9XpuBqfwX6Cu-UlYwqBqqW6i19lGD7_2Vr_n1k8o-4aVJHR_fJvd6OzMfdxD8gt0L7kNzpMktePSKzlPgu_5bQM_MOEwLsbfjKr1C-8xRTT7NCW_vr54-Qu_MlbnPzk5O8Px4bfJ7gOVaPydnR4afJMe0zJ9BGKLWmgsMuTViuvQb9XAofS-ZLXwnGQ4RxQ53QnpfeC--iQswYzwJIdxGdl8zxJ2SnXbThGcmldyD0vLGqsVVto5ZWlk3ktQVDBH7OCNvQzzQ9rDhmt_hqUnibK9PR3ADNTaK50Rl5M_yz7EA1bmx9gNMytERA7FSwuPhsevkyoqhYY7lrNCKUWaeErFR0AeH4udc2I3ubSTW9lK7MNU9l5NVQDfKFQRPbhsVlagM8JOsC2jzteGDoCefoXKirjMgt7tjq6nZNe_4lYXhLBcMsi4y83fDRdbf-T4rnN4_iBblbImsXjDK9R3bWF5fhJdhMazdKgjEiu-Px9OMU3geHp-8_QOmknoySHwKes0r9BgBCGp8
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELbKVgguiDeBAkaCE1iN7TixDwhRaLVLuyuEWqm31I5tqATZpbsF7Z-CH8EfY-w8quXRW2-R41jO-PN4xmN_g9DT1GthXVqRQmlwUKShRBvuCBQWXmrPfRruO48n-fAge3coDtfQj-4uTDhW2enEqKjttAp75Jss8LznwVt4NftKQtaoEF3tUmg0sNh1y-_gss1fjt7C-D5jbGd7_82QtFkFSCWkXBDBwYMRmiurYO1iwnpGLbOZoNx5ysF80UJZzqwV1ngZ-FQsdYD81BtbUMOh3UtoPePgygzQ-tb25P2HflcnxM0yqtrbOSmXm3NYIcMtNkaJhNYFUSsrYEwU8C_r9u9Dmn9EauMCuHMdXWstV_y6gdoNtObqm-hyk8tyeQuNY6o9_CXydeKGhQIsfHjCy6BRcIziRxyQWv_6-c1hczwLjjUejXB7INdZHAlB5rfRwYVI9Q4a1NPa3UO4sAbUDK-0rHSWa68KXbDK81yD6QMfJ4h28iurlsg85NP4XMaAOpdlI_MSZF5GmZcqQc_7b2YNjce5tbfCsPQ1AwV3LJiefCzbGV2KNKOV5qZSgRNNGymKTHrjQgIAbpVO0EY3qGWrF-blGYoT9KR_DTM6hGl07aansQ5gqMhTqHO3wUDfE87DdkaeJahYQcdKV1ff1MefImt4IeE3WZqgFx2Ozrr1f1HcP_8vHqMrw_3xXrk3muw-QFdZgHlKCVUbaLA4OXUPwWJbmEftNMHo6KJn5m8sDFGw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LjxQhECbrGo0X49vWVTHRk3amgaaBgzHqOtlx3Y0HN5kbQgO6ifaMO7Oa-VXevfrHLOjHZnzsbW8dGggUVUUVBV8h9KgIhjtf1LlQBhwUaUluLPM5FIogTWChiO-d9_arnYPyzZRPN9DP_i1MvFbZ68SkqN2sjmfkIxpx3qvoLYxCdy3i3fb4-fxrHjNIxUhrn06jZZFdv_oO7tvi2WQb1voxpePX71_t5F2GgbzmUi5zzsCb4YYpp2Afo9wFShx1JSfMB8LAlDFcOUad484GGbFVHPEgBUWwThDLoN9z6Lxg0ABkSUzFcL4TI2glUd07nYLJ0QL2yviejZJcQt88V2t7YUoZ8C879-_rmn_EbNNWOL6CLnc2LH7RMt1VtOGba-hCm9VydR3tpaR7-EtC7sQtHgXY-vCFV1G34BTPTxyRN-bXj28e28N5dLHxZIK7q7ne4QQNsriBDs6EpjfRZjNr_G2EhbOgcFhtZG3KygQljKB1YJUBIwgaZ4j09NN1B2keM2t81im0zqRuaa6B5jrRXKsMPRnazFtAj1Nrv4zLMtSMYNypYHb0UXeyrXlRktowW6uIjmas5KKUwfqYCoA5ZTK01S-q7jTEQp_wc4YeDr9BtmPAxjR-dpzqAA-JqoA6t1oeGEbCWDzYqMoMiTXuWBvq-p_m8FPCDxcSpkmLDD3t-ehkWP8nxZ3TZ_EAXQR51G8n-7t30SUaubwgOVFbaHN5dOzvgem2tPeTjGD04ayF8jdAO1SA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=White+matter+integrity+in+young+medication-na%C3%AFve+bipolar+II+depressed+adults&rft.jtitle=Scientific+reports&rft.au=Mak+Arthur+Dun+Ping&rft.au=Leung+Owen+Ngo+Wang&rft.au=Chou+Idy+Wing+Yi&rft.au=Wong+Sheila+Lok+Yiu&rft.date=2021-01-19&rft.pub=Nature+Publishing+Group&rft.eissn=2045-2322&rft.volume=11&rft.issue=1&rft_id=info:doi/10.1038%2Fs41598-021-81355-9&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon