Protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe disease: a systematic review and meta-regression

• Published in: The Lancet infectious diseases Vol. 23; no. 5; pp. 556 - 567
• Main Authors: Bobrovitz, Niklas, Ware, Harriet, Ma, Xiaomeng, Li, Zihan, Hosseini, Reza, Cao, Christian, Selemon, Anabel, Whelan, Mairead, Premji, Zahra, Issa, Hanane, Cheng, Brianna, Abu Raddad, Laith J, Buckeridge, David L, Van Kerkhove, Maria D, Piechotta, Vanessa, Higdon, Melissa M, Wilder-Smith, Annelies, Bergeri, Isabel, Feikin, Daniel R, Arora, Rahul K, Patel, Minal K, Subissi, Lorenzo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.05.2023; World Health Organization. Published by Elsevier Ltd
• Subjects: Adaptive Immunity; COVID-19 - prevention & control; Cross-Sectional Studies; Humans; Reinfection - prevention & control; SARS-CoV-2

The global surge in the omicron (B.1.1.529) variant has resulted in many individuals with hybrid immunity (immunity developed through a combination of SARS-CoV-2 infection and vaccination). We aimed to systematically review the magnitude and duration of the protective effectiveness of previous SARS-...