The interferon landscape along the respiratory tract impacts the severity of COVID-19

• Published in: Cell Vol. 184; no. 19; pp. 4953 - 4968.e16
• Main Authors: Sposito, Benedetta, Broggi, Achille, Pandolfi, Laura, Crotta, Stefania, Clementi, Nicola, Ferrarese, Roberto, Sisti, Sofia, Criscuolo, Elena, Spreafico, Roberto, Long, Jaclyn M., Ambrosi, Alessandro, Liu, Enju, Frangipane, Vanessa, Saracino, Laura, Bozzini, Sara, Marongiu, Laura, Facchini, Fabio A., Bottazzi, Andrea, Fossali, Tommaso, Colombo, Riccardo, Clementi, Massimo, Tagliabue, Elena, Chou, Janet, Pontiroli, Antonio E., Meloni, Federica, Wack, Andreas, Mancini, Nicasio, Zanoni, Ivan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 16.09.2021; Elsevier; Cell Press
• Subjects: Age Factors; Aging - pathology; airways; apoptosis; COVID-19; COVID-19 - genetics; COVID-19 - immunology; COVID-19 - pathology; COVID-19 infection; dendritic cell; epithelial cell; Epithelial Cells - pathology; Epithelial Cells - virology; Gene Expression Regulation; genes; Humans; interferon; interferons; Interferons - genetics; Interferons - metabolism; landscapes; Leukocytes - pathology; Leukocytes - virology; Life Sciences; lung; Lung - pathology; Lung - virology; lungs; pattern recognition receptor; Respiratory Distress Syndrome - pathology; Respiratory Distress Syndrome - virology; Respiratory System - virology; risk; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Severity of Illness Index; Type I IFN; Type III IFN; Viral Load; COVID-19; lung; Type III IFN; SARS-CoV-2; airways; interferon; epithelial cell; Type I IFN; dendritic cell; pattern recognition receptor

Severe coronavirus disease 2019 (COVID-19) is characterized by overproduction of immune mediators, but the role of interferons (IFNs) of the type I (IFN-I) or type III (IFN-III) families remains debated. We scrutinized the production of IFNs along the respiratory tract of COVID-19 patients and found...