Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder

• Published in: Scientific reports Vol. 10; no. 1; p. 1961
• Main Authors: Sakurai, Masashi, Yamamoto, Yasuko, Kanayama, Noriyo, Hasegawa, Masaya, Mouri, Akihiro, Takemura, Masao, Matsunami, Hidetoshi, Miyauchi, Tomoya, Tokura, Tatsuya, Kimura, Hiroyuki, Ito, Mikiko, Umemura, Eri, (Boku), Aiji Sato, Nagashima, Wataru, Tonoike, Takashi, Kurita, Kenichi, Ozaki, Norio, Nabeshima, Toshitaka, Saito, Kuniaki
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.02.2020; Nature Publishing Group
• Subjects: 3-Hydroxyanthranilic Acid - analysis; 3-Hydroxyanthranilic Acid - metabolism; 692/53/2423; 692/699/476/1414; Adult; Animal models; Animals; Anthranilic acid; Biomarkers - blood; Biomarkers - metabolism; Case-Control Studies; Chronic pain; Chronic Pain - blood; Chronic Pain - diagnosis; Chronic Pain - metabolism; Depressive Disorder, Major - blood; Depressive Disorder, Major - diagnosis; Depressive Disorder, Major - metabolism; Disease Models, Animal; Female; Healthy Volunteers; Humanities and Social Sciences; Humans; Interleukin 1; Interleukin 1 receptor antagonist; Interleukin 1 Receptor Antagonist Protein - blood; Kynurenic acid; Kynurenic Acid - blood; Kynurenic Acid - metabolism; Kynurenine - analogs & derivatives; Kynurenine - blood; Kynurenine - metabolism; Male; Mental depression; Metabolites; Metabolome; Mice; Middle Aged; multidisciplinary; ortho-Aminobenzoates - blood; ortho-Aminobenzoates - metabolism; Psychiatric Status Rating Scales; Science; Science (multidisciplinary); Stress, Psychological - blood; Stress, Psychological - diagnosis; Stress, Psychological - metabolism; Tryptophan; Tryptophan - metabolism

Previous reports have shown that during chronic inflammation, the tryptophan (TRP)-kynurenine (KYN) pathway plays a pivotal role in the onset of depression. The aim of this study was to investigate the characteristics of the serum TRP-KYN pathway metabolite profile in high-risk subjects of major dep...