Proneural Transcription Factors Regulate Different Steps of Cortical Neuron Migration through Rnd-Mediated Inhibition of RhoA Signaling

• Published in: Neuron (Cambridge, Mass.) Vol. 69; no. 6; pp. 1069 - 1084
• Main Authors: Pacary, Emilie, Heng, Julian, Azzarelli, Roberta, Riou, Philippe, Castro, Diogo, Lebel-Potter, Mélanie, Parras, Carlos, Bell, Donald M., Ridley, Anne J., Parsons, Maddy, Guillemot, François
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 24.03.2011; Elsevier Limited; Cell Press
• Subjects: Analysis of Variance; Animals; Basic Helix-Loop-Helix Transcription Factors - metabolism; Blotting, Western; Brain research; Cell adhesion & migration; Cell Count; Cell Movement - physiology; Cerebral Cortex - cytology; Cerebral Cortex - metabolism; Cytoskeleton; Fluorescence Resonance Energy Transfer; Immunohistochemistry; In Situ Hybridization; Kinases; Mice; Neurogenesis; Neurons; Neurons - metabolism; Neurons - physiology; Proteins; rho GTP-Binding Proteins - metabolism; rhoA GTP-Binding Protein - antagonists & inhibitors; RNA Interference; Scholarships & fellowships; Signal Transduction - physiology; Transcription factors

Little is known of the intracellular machinery that controls the motility of newborn neurons. We have previously shown that the proneural protein Neurog2 promotes the migration of nascent cortical neurons by inducing the expression of the atypical Rho GTPase Rnd2. Here, we show that another proneura...