Differential regulation by exercise of BDNF and NT-3 in rat spinal cord and skeletal muscle

• Published in: The European journal of neuroscience Vol. 13; no. 6; pp. 1078 - 1084
• Main Authors: Gómez-Pinilla, F., Ying, Z., Opazo, P., Roy, R. R., Edgerton, V. R.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.03.2001
• Subjects: activity-dependency; Animals; Brain-Derived Neurotrophic Factor - genetics; Brain-Derived Neurotrophic Factor - metabolism; exercise; Motor Activity - physiology; Muscle, Skeletal - metabolism; neuromuscular system; Neurotrophin 3 - genetics; Neurotrophin 3 - metabolism; neurotrophins; rat; Rats; Rats, Sprague-Dawley; rehabilitation; RNA, Messenger - metabolism; Space life sciences; Spinal Cord - metabolism; trophic factors; Non-programmatic

We have investigated the impact of neuromuscular activity on the expression of neurotrophins in the lumbar spinal cord region and innervating skeletal muscle of adult rats. Rats were exercised on a treadmill for 1 day or 5 consecutive days and euthanized at 0, 2 or 6 h after the last bout of exercis...