ATF6 Is a Critical Determinant of CHOP Dynamics during the Unfolded Protein Response

• Published in: iScience Vol. 23; no. 2; p. 100860
• Main Authors: Yang, Huan, Niemeijer, Marije, van de Water, Bob, Beltman, Joost B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.02.2020; Elsevier
• Subjects: Biocomputational Method; Bioinformatics; Optical Imaging; Systems Biology; Optical Imaging; Biocomputational Method; Bioinformatics; Systems Biology

The unfolded protein response (UPR) pathway senses unfolded proteins and regulates proteostasis and cell fate through activity of the transcription factors ATF4, ATF6, and XBP1 within a complex network of three main branches. Here, we investigated contributions of the three branches to UPR activity...