Detectable clonal mosaicism in blood as a biomarker of cancer risk in Fanconi anemia

• Published in: Blood advances Vol. 1; no. 5; pp. 319 - 329
• Main Authors: Reina-Castillón, Judith, Pujol, Roser, López-Sánchez, Marcos, Rodríguez-Santiago, Benjamín, Aza-Carmona, Miriam, González, Juan Ramón, Casado, José Antonio, Bueren, Juan Antonio, Sevilla, Julián, Badel, Isabel, Català, Albert, Beléndez, Cristina, Dasí, María Ángeles, Díaz de Heredia, Cristina, Soulier, Jean, Schindler, Detlev, Pérez-Jurado, Luis Alberto, Surrallés, Jordi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 24.01.2017; American Society of Hematology; Elsevier
• Subjects: Biochemical markers; Cancer; Càncer; Marcadors bioquímics; Myeloid Neoplasia

Detectable clonal mosaicism for large chromosomal events has been associated with aging and an increased risk of hematological and some solid cancers. We hypothesized that genetic cancer predisposition disorders, such as Fanconi anemia (FA), could manifest a high rate of chromosomal mosaic events (C...