Low ketolytic enzyme levels in tumors predict ketogenic diet responses in cancer cell lines in vitro and in vivo

• Published in: Journal of lipid research Vol. 59; no. 4; pp. 625 - 634
• Main Authors: Zhang, Jie, Jia, Ping-Ping, Liu, Qing-Le, Cong, Ming-Hua, Gao, Yun, Shi, Han-Ping, Yu, Wei-Nan, Miao, Ming-Yong
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2018; Journal of Lipid Research; The American Society for Biochemistry and Molecular Biology; Elsevier
• Subjects: 3-Hydroxybutyrate dehydrogenase; Animal models; Animals; BDH1; Cancer; Cell culture; Cell Proliferation; Clinical trials; CoA transferase; Coenzyme A-Transferases - genetics; Coenzyme A-Transferases - metabolism; Diet, Ketogenic; Enzymes; HeLa; High carbohydrate diet; High fat diet; Humans; Hydroxybutyrate Dehydrogenase - genetics; Hydroxybutyrate Dehydrogenase - metabolism; Ketogenesis; ketogenic diet; ketone bodies; Ketone Bodies - metabolism; Ketones; Low carbohydrate diet; Low fat diet; Male; metabolism; Mice; Mice, Nude; Neoplasms - metabolism; Neoplasms - pathology; Neoplasms - therapy; Nutrient deficiency; OXCT1; PANC-1; Rodents; Succinyl-CoA; Tumor cell lines; Tumor Cells, Cultured; Tumors; xenograft; Xenografts; HeLa; BDH1; xenograft; ketogenic diet; OXCT1; PANC-1; ketone bodies; cancer; metabolism

The ketogenic diet (KD) is a high-fat, very-low-carbohydrate diet that triggers a fasting state by decreasing glucose and increasing ketone bodies, such as β-hydroxybutyrate (βHB). In experimental models and clinical trials, the KD has shown anti-tumor effects, possibly by reducing energy supplies t...