Treatment with a GPIIb/IIIa antagonist inhibits thrombin generation in platelet rich plasma from patients
Infusion of the GPIIb/IIIa-inhibitor MK383 inhibits thrombin generation in platelet rich plasma by interfering with the production of platelet procoagulant phospholipid exposure. The effect is similar to that of 0.2 U/ml of heparin. Heparin infusion, well known to inhibit thrombin generation by fost...
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| Published in | Thrombosis and haemostasis Vol. 80; no. 3; p. 370 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Germany
01.09.1998
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| Subjects | |
| Online Access | Get more information |
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| Abstract | Infusion of the GPIIb/IIIa-inhibitor MK383 inhibits thrombin generation in platelet rich plasma by interfering with the production of platelet procoagulant phospholipid exposure. The effect is similar to that of 0.2 U/ml of heparin. Heparin infusion, well known to inhibit thrombin generation by fostering antithrombin activity, inhibits the formation of platelet-derived procoagulant microparticles, probably by decreasing the formation of free thrombin, which, under our circumstances, is the main platelet activator. |
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| AbstractList | Infusion of the GPIIb/IIIa-inhibitor MK383 inhibits thrombin generation in platelet rich plasma by interfering with the production of platelet procoagulant phospholipid exposure. The effect is similar to that of 0.2 U/ml of heparin. Heparin infusion, well known to inhibit thrombin generation by fostering antithrombin activity, inhibits the formation of platelet-derived procoagulant microparticles, probably by decreasing the formation of free thrombin, which, under our circumstances, is the main platelet activator. |
| Author | de Zwaan, C Hemker, H C Keularts, I M Béguin, S |
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| SubjectTerms | Angina, Unstable - blood Angina, Unstable - drug therapy Heparin - pharmacology Heparin - therapeutic use Humans Injections, Intravenous Myocardial Infarction - blood Myocardial Infarction - drug therapy Platelet Aggregation Inhibitors - pharmacology Platelet Aggregation Inhibitors - therapeutic use Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors Thrombin - antagonists & inhibitors Thrombin - biosynthesis Tyrosine - analogs & derivatives Tyrosine - pharmacology Tyrosine - therapeutic use |
| Title | Treatment with a GPIIb/IIIa antagonist inhibits thrombin generation in platelet rich plasma from patients |
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