Non-muscle Myosin-II Is Required for the Generation of a Constriction Site for Subsequent Abscission

• Published in: iScience Vol. 13; pp. 69 - 81
• Main Authors: Wang, Kangji, Wloka, Carsten, Bi, Erfei
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 29.03.2019; Elsevier
• Subjects: Cell Biology; Functional Aspects of Cell Biology; Molecular Biology; Molecular Biology; Functional Aspects of Cell Biology; Cell Biology

It remains unknown when, where, and how the site of abscission is generated during cytokinesis. Here, we show that the sites of constriction, i.e., the sites of future abscission, are initially formed at the ends of the intercellular bridge during early midbody stage, and that these sites are associ...