Research progress of in-situ gelling ophthalmic drug delivery system
Blindness and vision impairment are the most devastating global health problems resulting in a substantial economic and social burden. Delivery of drug to particular parts of the anterior or posterior segment has been a major challenge due to various protective barriers and elimination mechanisms as...
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| Published in | Asian journal of pharmceutical sciences Vol. 14; no. 1; pp. 1 - 15 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.01.2019
Shenyang Pharmaceutical University Elsevier |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Blindness and vision impairment are the most devastating global health problems resulting in a substantial economic and social burden. Delivery of drug to particular parts of the anterior or posterior segment has been a major challenge due to various protective barriers and elimination mechanisms associated with the unique anatomical and physiological nature of the ocular system. Drug administration to the eye by conventional delivery systems results in poor ocular bioavailability (<5%). The designing of a novel approach for a safe, simple, and effective ocular drug delivery is a major concern and requires innovative strategies to combat the problem. Over the past decades, several novel approaches involving different strategies have been developed to improve the ocular delivery system. Among these, the ophthalmic in-situ gel has attained a great attention over the past few years. This review discussed and summarized the recent and the promising research progress of in-situ gelling in ocular drug delivery system.
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| AbstractList | Blindness and vision impairment are the most devastating global health problems resulting in a substantial economic and social burden. Delivery of drug to particular parts of the anterior or posterior segment has been a major challenge due to various protective barriers and elimination mechanisms associated with the unique anatomical and physiological nature of the ocular system. Drug administration to the eye by conventional delivery systems results in poor ocular bioavailability (<5%). The designing of a novel approach for a safe, simple, and effective ocular drug delivery is a major concern and requires innovative strategies to combat the problem. Over the past decades, several novel approaches involving different strategies have been developed to improve the ocular delivery system. Among these, the ophthalmic in-situ gel has attained a great attention over the past few years. This review discussed and summarized the recent and the promising research progress of in-situ gelling in ocular drug delivery system.Blindness and vision impairment are the most devastating global health problems resulting in a substantial economic and social burden. Delivery of drug to particular parts of the anterior or posterior segment has been a major challenge due to various protective barriers and elimination mechanisms associated with the unique anatomical and physiological nature of the ocular system. Drug administration to the eye by conventional delivery systems results in poor ocular bioavailability (<5%). The designing of a novel approach for a safe, simple, and effective ocular drug delivery is a major concern and requires innovative strategies to combat the problem. Over the past decades, several novel approaches involving different strategies have been developed to improve the ocular delivery system. Among these, the ophthalmic in-situ gel has attained a great attention over the past few years. This review discussed and summarized the recent and the promising research progress of in-situ gelling in ocular drug delivery system. Blindness and vision impairment are the most devastating global health problems resulting in a substantial economic and social burden. Delivery of drug to particular parts of the anterior or posterior segment has been a major challenge due to various protective barriers and elimination mechanisms associated with the unique anatomical and physiological nature of the ocular system. Drug administration to the eye by conventional delivery systems results in poor ocular bioavailability (<5%). The designing of a novel approach for a safe, simple, and effective ocular drug delivery is a major concern and requires innovative strategies to combat the problem. Over the past decades, several novel approaches involving different strategies have been developed to improve the ocular delivery system. Among these, the ophthalmic in-situ gel has attained a great attention over the past few years. This review discussed and summarized the recent and the promising research progress of in-situ gelling in ocular drug delivery system. Image, graphical abstract Blindness and vision impairment are the most devastating global health problems resulting in a substantial economic and social burden. Delivery of drug to particular parts of the anterior or posterior segment has been a major challenge due to various protective barriers and elimination mechanisms associated with the unique anatomical and physiological nature of the ocular system. Drug administration to the eye by conventional delivery systems results in poor ocular bioavailability (<5%). The designing of a novel approach for a safe, simple, and effective ocular drug delivery is a major concern and requires innovative strategies to combat the problem. Over the past decades, several novel approaches involving different strategies have been developed to improve the ocular delivery system. Among these, the ophthalmic in-situ gel has attained a great attention over the past few years. This review discussed and summarized the recent and the promising research progress of in-situ gelling in ocular drug delivery system. Keywords: In-situ gel, Ocular, Drug delivery, Bioavailability, Polymer, Corneal retention Blindness and vision impairment are the most devastating global health problems resulting in a substantial economic and social burden. Delivery of drug to particular parts of the anterior or posterior segment has been a major challenge due to various protective barriers and elimination mechanisms associated with the unique anatomical and physiological nature of the ocular system. Drug administration to the eye by conventional delivery systems results in poor ocular bioavailability (<5%). The designing of a novel approach for a safe, simple, and effective ocular drug delivery is a major concern and requires innovative strategies to combat the problem. Over the past decades, several novel approaches involving different strategies have been developed to improve the ocular delivery system. Among these, the ophthalmic in-situ gel has attained a great attention over the past few years. This review discussed and summarized the recent and the promising research progress of in-situ gelling in ocular drug delivery system. Blindness and vision impairment are the most devastating global health problems resulting in a substantial economic and social burden. Delivery of drug to particular parts of the anterior or posterior segment has been a major challenge due to various protective barriers and elimination mechanisms associated with the unique anatomical and physiological nature of the ocular system. Drug administration to the eye by conventional delivery systems results in poor ocular bioavailability (<5%). The designing of a novel approach for a safe, simple, and effective ocular drug delivery is a major concern and requires innovative strategies to combat the problem. Over the past decades, several novel approaches involving different strategies have been developed to improve the ocular delivery system. Among these, the ophthalmic in-situ gel has attained a great attention over the past few years. This review discussed and summarized the recent and the promising research progress of in-situ gelling in ocular drug delivery system. [Display omitted] |
| Author | Liu, Zhidong Zhang, Bing Wu, Yumei Du, Shouying Liu, Yuanyuan Lu, Jun Ren, Jing Li, Jiawei Li, Xinyue Kebebe, Dereje |
| AuthorAffiliation | e School of Pharmacy, Institute of Health Sciences, Jimma University, Jimma, Ethiopia b Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China c Department of Experimental Department, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China a Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China d School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China f School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300193, China |
| AuthorAffiliation_xml | – name: e School of Pharmacy, Institute of Health Sciences, Jimma University, Jimma, Ethiopia – name: a Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China – name: d School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China – name: f School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300193, China – name: b Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China – name: c Department of Experimental Department, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
| Author_xml | – sequence: 1 givenname: Yumei orcidid: 0000-0001-5409-1794 surname: Wu fullname: Wu, Yumei organization: Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China – sequence: 2 givenname: Yuanyuan surname: Liu fullname: Liu, Yuanyuan organization: Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China – sequence: 3 givenname: Xinyue surname: Li fullname: Li, Xinyue organization: Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China – sequence: 4 givenname: Dereje surname: Kebebe fullname: Kebebe, Dereje organization: Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China – sequence: 5 givenname: Bing surname: Zhang fullname: Zhang, Bing organization: Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China – sequence: 6 givenname: Jing surname: Ren fullname: Ren, Jing organization: Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China – sequence: 7 givenname: Jun surname: Lu fullname: Lu, Jun organization: School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300193, China – sequence: 8 givenname: Jiawei surname: Li fullname: Li, Jiawei organization: Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China – sequence: 9 givenname: Shouying surname: Du fullname: Du, Shouying email: dushouying@263.net organization: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China – sequence: 10 givenname: Zhidong orcidid: 0000-0003-4449-6725 surname: Liu fullname: Liu, Zhidong email: lonerliuzd@163.com organization: Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Copyright | 2018 Shenyang Pharmaceutical University 2018 Shenyang Pharmaceutical University. Published by Elsevier B.V. 2018 Shenyang Pharmaceutical University. Published by Elsevier B.V. 2018 Shenyang Pharmaceutical University |
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| PublicationDate | 2019-01-01 |
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| PublicationTitle | Asian journal of pharmceutical sciences |
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| Publisher | Elsevier B.V Shenyang Pharmaceutical University Elsevier |
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