Multi-drug carbapenem-resistant Klebsiella pneumoniae infection carrying the OXA-48 gene and showing variations in outer membrane protein 36 causing an outbreak in a tertiary care hospital in Riyadh, Saudi Arabia

• Published in: International journal of infectious diseases Vol. 28; no. C; pp. 186 - 192
• Main Authors: uz Zaman, Taher, Aldrees, Mohammed, Al Johani, Sameera M, Alrodayyan, Maha, Aldughashem, Faizah A, Balkhy, Hanan H
• Format: Journal Article
• Language: English
• Published: Canada Elsevier Ltd 01.11.2014; Elsevier
• Subjects: Anti-Bacterial Agents - pharmacology; Bacterial Outer Membrane Proteins - chemistry; beta-Lactamases - genetics; Carbapenem resistance; Carbapenems - pharmacology; Disease Outbreaks; Drug Resistance, Multiple, Bacterial - genetics; Extended-spectrum beta-lactamases; Genes, Bacterial; Genetic Variation; Humans; Infectious Disease; Klebsiella Infections - epidemiology; Klebsiella Infections - microbiology; Klebsiella pneumoniae; Klebsiella pneumoniae - drug effects; Klebsiella pneumoniae - genetics; Klebsiella pneumoniae - isolation & purification; Outer membrane protein; Pulmonary/Respiratory; Saudi Arabia; Tertiary Care Centers; Saudi Arabia; Saudi Arabia; Extended-spectrum beta-lactamases; Carbapenem resistance; Klebsiella pneumoniae; Outer membrane protein

Summary Objectives To investigate the genes of antibiotic resistance among isolates from the first reported carbapenem-resistant Klebsiella pneumoniae (CRKP) outbreak in a tertiary care hospital, Riyadh, Saudi Arabia. Methods Antimicrobial susceptibility testing was performed on bacterial isolates u...