Infection with carcinogenic helminth parasites and its production of metabolites induces the formation of DNA-adducts

• Published in: Infectious agents and cancer Vol. 14; no. 1; pp. 41 - 9
• Main Authors: Gouveia, Maria João, Brindley, Paul J, Rinaldi, Gabriel, Gärtner, Fátima, da Costa, José M C, Vale, Nuno
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 29.11.2019; BioMed Central; BMC
• Subjects: (max. 10): Helminth infection; Analysis; Cancer; Carcinogenesis; Carcinogens; Catechol; Chromatography; Cytochrome P-450; Cytochrome P450; Deoxyribonucleic acid; DNA; DNA adducts; Enzymes; Estrogens; Fluke infections; Genes; Genetic research; Health aspects; Infection; Infections; Inflammation; Isoforms; Liquid chromatography; Malignancy; Mass spectrometry; Mass spectroscopy; Medical prognosis; Metabolism; Metabolites; Opisthorchiasis; Oxysterol; Parasites; Phenols (Class of compounds); Physiological aspects; Schistosomiasis; Scientific imaging; Sex hormones; Sodium; Spectroscopy; Germany; Schistosomiasis; (max. 10): Helminth infection; Malignancy; Cytochrome P450; Opisthorchiasis; Oxysterol

Infections classified as group 1 biological carcinogens include the helminthiases caused by and . The molecular mediators underlying the infection with these parasites and cancer remain unclear. Although carcinogenesis is a multistep process, we have postulated that these parasites release metabolit...