Barriers and Strategies of Cationic Liposomes for Cancer Gene Therapy

• Published in: Molecular therapy. Methods & clinical development Vol. 18; pp. 751 - 764
• Main Authors: Liu, Chunyan, Zhang, Ligang, Zhu, Wenhui, Guo, Raoqing, Sun, Huamin, Chen, Xi, Deng, Ning
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 11.09.2020; American Society of Gene & Cell Therapy; Elsevier
• Subjects: cancer gene therapy; cationic liposomes; extracellular barriers; gene transfer; intracellular barriers; lipid compositions; lipoplexes; cancer gene therapy; gene transfer; cationic liposomes; lipid compositions; lipoplexes; extracellular barriers; intracellular barriers

Cationic liposomes (CLs) have been regarded as the most promising gene delivery vectors for decades with the advantages of excellent biodegradability, biocompatibility, and high nucleic acid encapsulation efficiency. However, the clinical use of CLs in cancer gene therapy is limited because of many...