Transcriptional Profiling of the Adult Hair Follicle Mesenchyme Reveals R-spondin as a Novel Regulator of Dermal Progenitor Function

• Published in: iScience Vol. 23; no. 4; p. 101019
• Main Authors: Hagner, Andrew, Shin, Wisoo, Sinha, Sarthak, Alpaugh, Whitney, Workentine, Matthew, Abbasi, Sepideh, Rahmani, Waleed, Agabalyan, Natacha, Sharma, Nilesh, Sparks, Holly, Yoon, Jessica, Labit, Elodie, Cobb, John, Dobrinski, Ina, Biernaskie, Jeff
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 24.04.2020; Elsevier
• Subjects: Biological Sciences; Developmental Biology; Stem Cells Research; Developmental Biology; Biological Sciences; Stem Cells Research

The adult hair follicle (HF) undergoes successive regeneration driven by resident epithelial stem cells and neighboring mesenchyme. Recent work described the existence of HF dermal stem cells (hfDSCs), but the genetic regulation of hfDSCs and their daughter cell lineages in HF regeneration remains u...