Transcriptional Profiling of the Adult Hair Follicle Mesenchyme Reveals R-spondin as a Novel Regulator of Dermal Progenitor Function
The adult hair follicle (HF) undergoes successive regeneration driven by resident epithelial stem cells and neighboring mesenchyme. Recent work described the existence of HF dermal stem cells (hfDSCs), but the genetic regulation of hfDSCs and their daughter cell lineages in HF regeneration remains u...
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| Published in | iScience Vol. 23; no. 4; p. 101019 |
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| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier Inc
24.04.2020
Elsevier |
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| Abstract | The adult hair follicle (HF) undergoes successive regeneration driven by resident epithelial stem cells and neighboring mesenchyme. Recent work described the existence of HF dermal stem cells (hfDSCs), but the genetic regulation of hfDSCs and their daughter cell lineages in HF regeneration remains unknown. Here we prospectively isolate functionally distinct mesenchymal compartment in the HF (dermal cup [DC; includes hfDSCs] and dermal papilla) and define the transcriptional programs involved in hfDSC function and acquisition of divergent mesenchymal fates. From this, we demonstrate cross-compartment mesenchymal signaling within the HF niche, whereby DP-derived R-spondins act to stimulate proliferation of both hfDSCs and epithelial progenitors during HF regeneration. Our findings describe unique transcriptional programs that underlie the functional heterogeneity among specialized fibroblasts within the adult HF and identify a novel regulator of mesenchymal progenitor function during tissue regeneration.
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•Transcriptional compartmentalization of the hair follicle mesenchyme•Hair follicle dermal stem cells (hfDSCs) exhibit a unique gene expression profile•DP-derived R-spondins coordinately activate hfDSCs and epithelial progenitors•Gene expression profiling of hair follicle dermal stem cells
Biological Sciences; Developmental Biology; Stem Cells Research |
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| AbstractList | The adult hair follicle (HF) undergoes successive regeneration driven by resident epithelial stem cells and neighboring mesenchyme. Recent work described the existence of HF dermal stem cells (hfDSCs), but the genetic regulation of hfDSCs and their daughter cell lineages in HF regeneration remains unknown. Here we prospectively isolate functionally distinct mesenchymal compartment in the HF (dermal cup [DC; includes hfDSCs] and dermal papilla) and define the transcriptional programs involved in hfDSC function and acquisition of divergent mesenchymal fates. From this, we demonstrate cross-compartment mesenchymal signaling within the HF niche, whereby DP-derived R-spondins act to stimulate proliferation of both hfDSCs and epithelial progenitors during HF regeneration. Our findings describe unique transcriptional programs that underlie the functional heterogeneity among specialized fibroblasts within the adult HF and identify a novel regulator of mesenchymal progenitor function during tissue regeneration.
[Display omitted]
•Transcriptional compartmentalization of the hair follicle mesenchyme•Hair follicle dermal stem cells (hfDSCs) exhibit a unique gene expression profile•DP-derived R-spondins coordinately activate hfDSCs and epithelial progenitors•Gene expression profiling of hair follicle dermal stem cells
Biological Sciences; Developmental Biology; Stem Cells Research The adult hair follicle (HF) undergoes successive regeneration driven by resident epithelial stem cells and neighboring mesenchyme. Recent work described the existence of HF dermal stem cells (hfDSCs), but the genetic regulation of hfDSCs and their daughter cell lineages in HF regeneration remains unknown. Here we prospectively isolate functionally distinct mesenchymal compartment in the HF (dermal cup [DC; includes hfDSCs] and dermal papilla) and define the transcriptional programs involved in hfDSC function and acquisition of divergent mesenchymal fates. From this, we demonstrate cross-compartment mesenchymal signaling within the HF niche, whereby DP-derived R-spondins act to stimulate proliferation of both hfDSCs and epithelial progenitors during HF regeneration. Our findings describe unique transcriptional programs that underlie the functional heterogeneity among specialized fibroblasts within the adult HF and identify a novel regulator of mesenchymal progenitor function during tissue regeneration. : Biological Sciences; Developmental Biology; Stem Cells Research Subject Areas: Biological Sciences, Developmental Biology, Stem Cells Research The adult hair follicle (HF) undergoes successive regeneration driven by resident epithelial stem cells and neighboring mesenchyme. Recent work described the existence of HF dermal stem cells (hfDSCs), but the genetic regulation of hfDSCs and their daughter cell lineages in HF regeneration remains unknown. Here we prospectively isolate functionally distinct mesenchymal compartment in the HF (dermal cup [DC; includes hfDSCs] and dermal papilla) and define the transcriptional programs involved in hfDSC function and acquisition of divergent mesenchymal fates. From this, we demonstrate cross-compartment mesenchymal signaling within the HF niche, whereby DP-derived R-spondins act to stimulate proliferation of both hfDSCs and epithelial progenitors during HF regeneration. Our findings describe unique transcriptional programs that underlie the functional heterogeneity among specialized fibroblasts within the adult HF and identify a novel regulator of mesenchymal progenitor function during tissue regeneration. The adult hair follicle (HF) undergoes successive regeneration driven by resident epithelial stem cells and neighboring mesenchyme. Recent work described the existence of HF dermal stem cells (hfDSCs), but the genetic regulation of hfDSCs and their daughter cell lineages in HF regeneration remains unknown. Here we prospectively isolate functionally distinct mesenchymal compartment in the HF (dermal cup [DC; includes hfDSCs] and dermal papilla) and define the transcriptional programs involved in hfDSC function and acquisition of divergent mesenchymal fates. From this, we demonstrate cross-compartment mesenchymal signaling within the HF niche, whereby DP-derived R-spondins act to stimulate proliferation of both hfDSCs and epithelial progenitors during HF regeneration. Our findings describe unique transcriptional programs that underlie the functional heterogeneity among specialized fibroblasts within the adult HF and identify a novel regulator of mesenchymal progenitor function during tissue regeneration.The adult hair follicle (HF) undergoes successive regeneration driven by resident epithelial stem cells and neighboring mesenchyme. Recent work described the existence of HF dermal stem cells (hfDSCs), but the genetic regulation of hfDSCs and their daughter cell lineages in HF regeneration remains unknown. Here we prospectively isolate functionally distinct mesenchymal compartment in the HF (dermal cup [DC; includes hfDSCs] and dermal papilla) and define the transcriptional programs involved in hfDSC function and acquisition of divergent mesenchymal fates. From this, we demonstrate cross-compartment mesenchymal signaling within the HF niche, whereby DP-derived R-spondins act to stimulate proliferation of both hfDSCs and epithelial progenitors during HF regeneration. Our findings describe unique transcriptional programs that underlie the functional heterogeneity among specialized fibroblasts within the adult HF and identify a novel regulator of mesenchymal progenitor function during tissue regeneration. The adult hair follicle (HF) undergoes successive regeneration driven by resident epithelial stem cells and neighboring mesenchyme. Recent work described the existence of HF dermal stem cells (hfDSCs), but the genetic regulation of hfDSCs and their daughter cell lineages in HF regeneration remains unknown. Here we prospectively isolate functionally distinct mesenchymal compartment in the HF (dermal cup [DC; includes hfDSCs] and dermal papilla) and define the transcriptional programs involved in hfDSC function and acquisition of divergent mesenchymal fates. From this, we demonstrate cross-compartment mesenchymal signaling within the HF niche, whereby DP-derived R-spondins act to stimulate proliferation of both hfDSCs and epithelial progenitors during HF regeneration. Our findings describe unique transcriptional programs that underlie the functional heterogeneity among specialized fibroblasts within the adult HF and identify a novel regulator of mesenchymal progenitor function during tissue regeneration. • Transcriptional compartmentalization of the hair follicle mesenchyme • Hair follicle dermal stem cells (hfDSCs) exhibit a unique gene expression profile • DP-derived R-spondins coordinately activate hfDSCs and epithelial progenitors • Gene expression profiling of hair follicle dermal stem cells Biological Sciences; Developmental Biology; Stem Cells Research |
| ArticleNumber | 101019 |
| Author | Abbasi, Sepideh Sparks, Holly Shin, Wisoo Yoon, Jessica Labit, Elodie Workentine, Matthew Rahmani, Waleed Hagner, Andrew Dobrinski, Ina Sinha, Sarthak Alpaugh, Whitney Sharma, Nilesh Agabalyan, Natacha Cobb, John Biernaskie, Jeff |
| AuthorAffiliation | 1 Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada 2 Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada 3 Alberta Children's Hospital Research Institute, Calgary, AB, Canada 4 Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada 5 Department of Biological Sciences, University of Calgary, Calgary, AB, Canada |
| AuthorAffiliation_xml | – name: 3 Alberta Children's Hospital Research Institute, Calgary, AB, Canada – name: 5 Department of Biological Sciences, University of Calgary, Calgary, AB, Canada – name: 4 Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada – name: 2 Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada – name: 1 Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada |
| Author_xml | – sequence: 1 givenname: Andrew surname: Hagner fullname: Hagner, Andrew organization: Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada – sequence: 2 givenname: Wisoo orcidid: 0000-0001-9727-7089 surname: Shin fullname: Shin, Wisoo organization: Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada – sequence: 3 givenname: Sarthak surname: Sinha fullname: Sinha, Sarthak organization: Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada – sequence: 4 givenname: Whitney surname: Alpaugh fullname: Alpaugh, Whitney organization: Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada – sequence: 5 givenname: Matthew surname: Workentine fullname: Workentine, Matthew organization: Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada – sequence: 6 givenname: Sepideh surname: Abbasi fullname: Abbasi, Sepideh organization: Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada – sequence: 7 givenname: Waleed surname: Rahmani fullname: Rahmani, Waleed organization: Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada – sequence: 8 givenname: Natacha surname: Agabalyan fullname: Agabalyan, Natacha organization: Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada – sequence: 9 givenname: Nilesh surname: Sharma fullname: Sharma, Nilesh organization: Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada – sequence: 10 givenname: Holly surname: Sparks fullname: Sparks, Holly organization: Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada – sequence: 11 givenname: Jessica surname: Yoon fullname: Yoon, Jessica organization: Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada – sequence: 12 givenname: Elodie surname: Labit fullname: Labit, Elodie organization: Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada – sequence: 13 givenname: John surname: Cobb fullname: Cobb, John organization: Department of Biological Sciences, University of Calgary, Calgary, AB, Canada – sequence: 14 givenname: Ina surname: Dobrinski fullname: Dobrinski, Ina organization: Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada – sequence: 15 givenname: Jeff surname: Biernaskie fullname: Biernaskie, Jeff email: jeff.biernaskie@ucalgary.ca organization: Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32289736$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/nbt.2361 10.1111/j.1523-1747.2003.12568.x 10.1172/JCI26043 10.1128/MCB.00272-12 10.1016/j.cell.2010.11.049 10.1101/gad.1614408 10.1111/exd.12608 10.1038/sj.onc.1207892 10.1038/emboj.2012.149 10.1242/dev.038620 10.1038/nature07935 10.1371/journal.pone.0160425 10.1038/311560a0 10.1016/j.stem.2011.11.005 10.1016/S0092-8674(00)00050-7 10.1016/j.stem.2009.10.019 10.1038/nchembio.137 10.1073/pnas.1106083108 10.1016/j.devcel.2014.10.022 10.1016/j.devcel.2015.06.023 10.1016/j.celrep.2016.02.078 10.1371/journal.pone.0078144 10.1073/pnas.1309970110 10.1016/j.stem.2008.12.009 10.1146/annurev.physiol.010908.163145 10.1038/nature11218 10.1371/journal.pone.0040976 10.1016/j.devcel.2012.10.013 10.1016/j.cell.2014.02.057 10.1242/jcs.105700 10.1083/jcb.200309042 10.1002/dvg.22040 10.1371/journal.pbio.0030331 10.1038/jid.2008.361 10.1046/j.1523-1747.2000.00951.x 10.1101/gad.235473.113 10.1126/science.1092436 10.1016/j.stem.2009.11.013 10.1038/nature06196 10.1016/j.jid.2016.01.041 10.1038/ng.239 10.1016/j.cels.2016.08.010 |
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| References | Barker, van Es, Kuipers, Kujala, van den Born, Cozijnsen, Haegebarth, Korving, Begthel, Peters (bib3) 2007; 449 Neufeld, Rosin, Ambasta, Hui, Shaneman, Crowder, Vickerman, Cobb (bib20) 2012; 50 Jaks, Barker, Kasper, van Es, Snippert, Clevers, Toftgard (bib17) 2008; 40 Chen, Dodge, Tang, Lu, Ma, Fan, Wei, Hao, Kilgore, WIlliams, Roth, Amatruda, Chen, Lum (bib8) 2009; 5 Carmon, Lin, Gong, Thomas, Liu (bib7) 2012; 32 Higgins, Chen, Cerise, Jahoda, Christiano (bib14) 2013; 110 Rendl, Lewis, Fuchs (bib25) 2005; 3 Carmon, Gong, Lin, Thomas, Liu (bib6) 2011; 108 Driskell, Giangreco, Jensen, Mulder, Watt (bib12) 2009; 136 de Lau, Peng, Gros, Clevers (bib11) 2014; 28 Barker, Huch, Kujala, van de Wetering, Snippert, van Es, Sato, Stange, Begthel, van den Born (bib2) 2010; 6 Ohyama, Kobayashi, Sasaki, Shimizu, Amagai (bib21) 2012; 125 Smith, Li, Liu, Hunter, Pyles, Gillette, Dhamdhere, Abo, Oro, Helms (bib32) 2016; 136 Hsu, Li, Fuchs (bib15) 2014; 157 Rompolas, Deschene, Zito, Gonzalez, Saotome, Haberman, Greco (bib27) 2012; 487 Clavel, Grisanti, Zemla, Rezza, Barros, Sennett, Mazloom, Chung, Cai, Cai (bib10) 2012; 23 Niida, Hiroko, Kasai, Furukawa, Nakamura, Suzuki, Sugano, Akiyama (bib40) 2004; 23 Rezza, Wang, Sennett, Qiao, Wang, Heitman, Mok, Clavel, Yi, Zandstra (bib26) 2016; 14 Wang, Liu, Gambardella, Delacour, Shapiro, Yang, Sizing, Rayhorn, Garber, Benjamin (bib36) 2000; 114 Biernaskie, Paris, Morozova, Fagan, Marra, Pevny, Miller (bib4) 2009; 5 Ohyama, Terunuma, Tock, Radonovich, Pise-Masison, Hopping, Brady, Udey, Vogel (bib22) 2006; 116 Oshimori, Fuchs (bib23) 2012; 10 van der Flier, Clevers (bib35) 2009; 71 Greco, Chen, Rendl, Schober, Pasolli, Stokes, Dela Cruz-Racelis, Fuchs (bib13) 2009; 4 Rahmani, Abbasi, Hagner, Raharjo, Kumar, Hotta, Magness, Metzger, Biernaskie (bib24) 2014; 31 Zhou, Xu, Yang, Yang, Wickett, Andl, Millar, Zhang (bib38) 2016; 11 Chi, Wu, Morgan (bib9) 2015; 24 Bodo, Kromminga, Biro, Borbiro, Gaspar, Zmijewski, van Beek, Langbein, Slominski, Paus (bib5) 2009; 129 McElwee, Kissling, Wenzel, Huth, Hoffmann (bib19) 2003; 121 Schuijers, Clevers (bib30) 2012; 31 Hsu, Pasolli, Fuchs (bib16) 2011; 144 Sato, Vries, Snippert, van de Wetering, Barker, Stange, van Es, Abo, Kujala, Peters (bib29) 2009; 459 Tumbar, Guasch, Greco, Blanpain, Lowry, Rendl, Fuchs (bib34) 2004; 303 Abo, Clevers (bib1) 2012; 30 Jahoda, Horne, Oliver (bib39) 1984 Taylor, Lehrer, Jensen, Sun, Lavker (bib33) 2000; 102 Ruffner, Sprunger, Charlat, Leighton-Davies, Grosshans, Salathe, Zietzling, Beck, Therier, Isken (bib28) 2012; 7 Joost, Zeisel, Jacob, Sun, La Manno, Lonnerberg, Linnarsson, Kasper (bib18) 2016; 3 Kobielak, Pasolli, Alonso, Polak, Fuchs (bib41) 2003; 163 Sennett, Wang, Rezza, Grisanti, Roitershtein, Sicchio, Mok, Heitman, Clavel, Ma'ayan (bib31) 2015; 34 Rendl, Polak, Fuchs (bib42) 2008; 22 Yi, Xiong, Gong, Bellister, Ellis, Liu (bib37) 2013; 8 Clavel (10.1016/j.isci.2020.101019_bib10) 2012; 23 Oshimori (10.1016/j.isci.2020.101019_bib23) 2012; 10 Carmon (10.1016/j.isci.2020.101019_bib7) 2012; 32 Hsu (10.1016/j.isci.2020.101019_bib16) 2011; 144 van der Flier (10.1016/j.isci.2020.101019_bib35) 2009; 71 Rompolas (10.1016/j.isci.2020.101019_bib27) 2012; 487 Ohyama (10.1016/j.isci.2020.101019_bib21) 2012; 125 Neufeld (10.1016/j.isci.2020.101019_bib20) 2012; 50 Rezza (10.1016/j.isci.2020.101019_bib26) 2016; 14 Schuijers (10.1016/j.isci.2020.101019_bib30) 2012; 31 Higgins (10.1016/j.isci.2020.101019_bib14) 2013; 110 Sato (10.1016/j.isci.2020.101019_bib29) 2009; 459 Zhou (10.1016/j.isci.2020.101019_bib38) 2016; 11 Tumbar (10.1016/j.isci.2020.101019_bib34) 2004; 303 Rahmani (10.1016/j.isci.2020.101019_bib24) 2014; 31 Yi (10.1016/j.isci.2020.101019_bib37) 2013; 8 Barker (10.1016/j.isci.2020.101019_bib3) 2007; 449 Smith (10.1016/j.isci.2020.101019_bib32) 2016; 136 Hsu (10.1016/j.isci.2020.101019_bib15) 2014; 157 Rendl (10.1016/j.isci.2020.101019_bib42) 2008; 22 Taylor (10.1016/j.isci.2020.101019_bib33) 2000; 102 Abo (10.1016/j.isci.2020.101019_bib1) 2012; 30 Biernaskie (10.1016/j.isci.2020.101019_bib4) 2009; 5 Driskell (10.1016/j.isci.2020.101019_bib12) 2009; 136 Ohyama (10.1016/j.isci.2020.101019_bib22) 2006; 116 Wang (10.1016/j.isci.2020.101019_bib36) 2000; 114 Jaks (10.1016/j.isci.2020.101019_bib17) 2008; 40 de Lau (10.1016/j.isci.2020.101019_bib11) 2014; 28 Barker (10.1016/j.isci.2020.101019_bib2) 2010; 6 Carmon (10.1016/j.isci.2020.101019_bib6) 2011; 108 Chi (10.1016/j.isci.2020.101019_bib9) 2015; 24 Jahoda (10.1016/j.isci.2020.101019_bib39) 1984 Kobielak (10.1016/j.isci.2020.101019_bib41) 2003; 163 Rendl (10.1016/j.isci.2020.101019_bib25) 2005; 3 Chen (10.1016/j.isci.2020.101019_bib8) 2009; 5 Niida (10.1016/j.isci.2020.101019_bib40) 2004; 23 Sennett (10.1016/j.isci.2020.101019_bib31) 2015; 34 Bodo (10.1016/j.isci.2020.101019_bib5) 2009; 129 McElwee (10.1016/j.isci.2020.101019_bib19) 2003; 121 Ruffner (10.1016/j.isci.2020.101019_bib28) 2012; 7 Greco (10.1016/j.isci.2020.101019_bib13) 2009; 4 Joost (10.1016/j.isci.2020.101019_bib18) 2016; 3 |
| References_xml | – volume: 129 start-page: 1126 year: 2009 end-page: 1139 ident: bib5 article-title: Human female hair follicles are a direct, nonclassical target for thyroid-stimulating hormone publication-title: J. Invest. Dermatol. – volume: 23 start-page: 8520 year: 2004 end-page: 8526 ident: bib40 article-title: DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway publication-title: Oncogene – volume: 10 start-page: 63 year: 2012 end-page: 75 ident: bib23 article-title: Paracrine TGF-beta signaling counterbalances BMPmediated repression in hair follicle stem cell activation publication-title: Cell Stem Cell – volume: 108 start-page: 11452 year: 2011 end-page: 11457 ident: bib6 article-title: R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling publication-title: Proc. Natl. Acad. Sci. U S A – volume: 487 start-page: 496 year: 2012 end-page: 499 ident: bib27 article-title: Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration publication-title: Nature – volume: 71 start-page: 241 year: 2009 end-page: 260 ident: bib35 article-title: Stem cells, self-renewal, and differentiation in the intestinal epithelium publication-title: Annu. Rev. Physiol. – start-page: 560 year: 1984 end-page: 562 ident: bib39 article-title: Induction of hair growth by implantation of cultured dermal papilla cells publication-title: Nature – volume: 40 start-page: 1291 year: 2008 end-page: 1299 ident: bib17 article-title: Lgr5 marks cycling, yet long-lived, hair follicle stem cells publication-title: Nat. Genet. – volume: 8 start-page: e78144 year: 2013 ident: bib37 article-title: Analysis of LGR4 receptor distribution in human and mouse tissues publication-title: PLoS One – volume: 11 start-page: e0160425 year: 2016 ident: bib38 article-title: Activation of beta-catenin signaling in CD133-positive dermal papilla cells drives postnatal hair growth publication-title: PLoS One – volume: 34 start-page: 577 year: 2015 end-page: 591 ident: bib31 article-title: An integrated transcriptome atlas of embryonic hair follicle progenitors, their niche, and the developing skin publication-title: Dev. Cell – volume: 163 start-page: 609 year: 2003 end-page: 623 ident: bib41 article-title: Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA publication-title: J. Cell Biol. – volume: 6 start-page: 25 year: 2010 end-page: 36 ident: bib2 article-title: Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro publication-title: Cell Stem Cell – volume: 31 start-page: 2685 year: 2012 end-page: 2696 ident: bib30 article-title: Adult mammalian stem cells: the role of Wnt, Lgr5 and Rspondins publication-title: EMBO J. – volume: 303 start-page: 359 year: 2004 end-page: 363 ident: bib34 article-title: Defining the epithelial stem cell niche in skin publication-title: Science – volume: 24 start-page: 265 year: 2015 end-page: 268 ident: bib9 article-title: Earlier-born secondary hair follicles exhibit phenotypic plasticity publication-title: Exp. Dermatol. – volume: 157 start-page: 935 year: 2014 end-page: 949 ident: bib15 article-title: Transit-amplifying cells orchestrate stem cell activity and tissue regeneration publication-title: Cell – volume: 3 start-page: 221 year: 2016 end-page: 237 e229 ident: bib18 article-title: Single-cell transcriptomics reveals that differentiation and spatial signatures shape epidermal and hair follicle heterogeneity publication-title: Cell Syst. – volume: 28 start-page: 305 year: 2014 end-page: 316 ident: bib11 article-title: The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength publication-title: Genes Dev. – volume: 30 start-page: 835 year: 2012 end-page: 836 ident: bib1 article-title: Modulating WNT receptor turnover for tissue repair publication-title: Nat. Biotechnol. – volume: 136 start-page: 28152823 year: 2009 ident: bib12 article-title: Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis publication-title: Development – volume: 144 start-page: 92 year: 2011 end-page: 105 ident: bib16 article-title: Dynamics between stem cells, niche, and progeny in the hair follicle publication-title: Cell – volume: 22 start-page: 543 year: 2008 end-page: 557 ident: bib42 article-title: BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties publication-title: Genes Dev. – volume: 449 start-page: 1003 year: 2007 end-page: 1007 ident: bib3 article-title: Identification of stem cells in small intestine and colon by marker gene Lgr5 publication-title: Nature – volume: 3 start-page: e331 year: 2005 ident: bib25 article-title: Molecular dissection of mesenchymal-epithelial interactions in the hair follicle publication-title: PLoS Biol. – volume: 5 start-page: 610 year: 2009 end-page: 623 ident: bib4 article-title: SKPs derive from hair follicle precursors and exhibit properties of adult dermal stem cells publication-title: Cell Stem Cell – volume: 110 start-page: 19679 year: 2013 end-page: 19688 ident: bib14 article-title: Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth publication-title: Proc. Natl. Acad. Sci. U S A – volume: 114 start-page: 901 year: 2000 end-page: 908 ident: bib36 article-title: Regular articles: conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration publication-title: J. Invest. Dermatol. – volume: 102 start-page: 451 year: 2000 end-page: 461 ident: bib33 article-title: Involvement of follicular stem cells in forming not only the follicle but also the epidermis publication-title: Cell – volume: 31 start-page: 543 year: 2014 end-page: 558 ident: bib24 article-title: Hair follicle dermal stem cells regenerate the dermal sheath, repopulate the dermal papilla, and modulate hair type publication-title: Dev. Cell – volume: 14 start-page: 3001 year: 2016 end-page: 3018 ident: bib26 article-title: Signaling networks among stem cell precursors, transit-amplifying progenitors, and their niche in developing hair follicles publication-title: Cell Rep. – volume: 116 start-page: 249 year: 2006 end-page: 260 ident: bib22 article-title: Characterization and isolation of stem cell enriched human hair follicle bulge cells publication-title: J. Clin. Invest. – volume: 4 start-page: 155 year: 2009 end-page: 169 ident: bib13 article-title: A two-step mechanism for stem cell activation during hair regeneration publication-title: Cell Stem Cell – volume: 121 start-page: 1267 year: 2003 end-page: 1275 ident: bib19 article-title: Cultured peribulbar dermal sheath cells can induce hair follicle development and contribute to the dermal sheath and dermal papilla publication-title: J. Invest. Dermatol. – volume: 459 start-page: 262 year: 2009 end-page: 265 ident: bib29 article-title: Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche publication-title: Nature – volume: 32 start-page: 2054 year: 2012 end-page: 2064 ident: bib7 article-title: LGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/beta-catenin signaling publication-title: Mol Cell Biol – volume: 136 start-page: 1549 year: 2016 end-page: 1558 ident: bib32 article-title: Activating hair follicle stem cells via R-spondin2 to stimulate hair growth publication-title: J. Invest. Dermatol. – volume: 23 start-page: 981 year: 2012 end-page: 994 ident: bib10 article-title: Sox2 in the dermal papilla niche controls hair growth by finetuning BMP signaling in differentiating hair shaft progenitors publication-title: Dev. Cell – volume: 7 start-page: e40976 year: 2012 ident: bib28 article-title: R-Spondin potentiates Wnt/beta-catenin signaling through orphan receptors LGR4 and LGR5 publication-title: PLoS One – volume: 50 start-page: 741 year: 2012 end-page: 749 ident: bib20 article-title: A conditional allele of Rspo3 reveals redundant function of R-spondins during mouse limb development publication-title: Genesis – volume: 5 start-page: 100 year: 2009 end-page: 107 ident: bib8 article-title: Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer publication-title: Nat. Chem. Biol. – volume: 125 start-page: 4114 year: 2012 end-page: 4125 ident: bib21 article-title: Restoration of the intrinsic properties of human dermal papilla in vitro publication-title: J. Cell Sci. – volume: 30 start-page: 835 year: 2012 ident: 10.1016/j.isci.2020.101019_bib1 article-title: Modulating WNT receptor turnover for tissue repair publication-title: Nat. Biotechnol. doi: 10.1038/nbt.2361 – volume: 121 start-page: 1267 year: 2003 ident: 10.1016/j.isci.2020.101019_bib19 article-title: Cultured peribulbar dermal sheath cells can induce hair follicle development and contribute to the dermal sheath and dermal papilla publication-title: J. Invest. Dermatol. doi: 10.1111/j.1523-1747.2003.12568.x – volume: 116 start-page: 249 year: 2006 ident: 10.1016/j.isci.2020.101019_bib22 article-title: Characterization and isolation of stem cell enriched human hair follicle bulge cells publication-title: J. Clin. Invest. doi: 10.1172/JCI26043 – volume: 32 start-page: 2054 year: 2012 ident: 10.1016/j.isci.2020.101019_bib7 article-title: LGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/beta-catenin signaling publication-title: Mol Cell Biol doi: 10.1128/MCB.00272-12 – volume: 144 start-page: 92 year: 2011 ident: 10.1016/j.isci.2020.101019_bib16 article-title: Dynamics between stem cells, niche, and progeny in the hair follicle publication-title: Cell doi: 10.1016/j.cell.2010.11.049 – volume: 22 start-page: 543 year: 2008 ident: 10.1016/j.isci.2020.101019_bib42 article-title: BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties publication-title: Genes Dev. doi: 10.1101/gad.1614408 – volume: 24 start-page: 265 year: 2015 ident: 10.1016/j.isci.2020.101019_bib9 article-title: Earlier-born secondary hair follicles exhibit phenotypic plasticity publication-title: Exp. Dermatol. doi: 10.1111/exd.12608 – volume: 23 start-page: 8520 year: 2004 ident: 10.1016/j.isci.2020.101019_bib40 article-title: DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway publication-title: Oncogene doi: 10.1038/sj.onc.1207892 – volume: 31 start-page: 2685 year: 2012 ident: 10.1016/j.isci.2020.101019_bib30 article-title: Adult mammalian stem cells: the role of Wnt, Lgr5 and Rspondins publication-title: EMBO J. doi: 10.1038/emboj.2012.149 – volume: 136 start-page: 28152823 year: 2009 ident: 10.1016/j.isci.2020.101019_bib12 article-title: Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis publication-title: Development doi: 10.1242/dev.038620 – volume: 459 start-page: 262 year: 2009 ident: 10.1016/j.isci.2020.101019_bib29 article-title: Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche publication-title: Nature doi: 10.1038/nature07935 – volume: 11 start-page: e0160425 year: 2016 ident: 10.1016/j.isci.2020.101019_bib38 article-title: Activation of beta-catenin signaling in CD133-positive dermal papilla cells drives postnatal hair growth publication-title: PLoS One doi: 10.1371/journal.pone.0160425 – start-page: 560 issue: 311 year: 1984 ident: 10.1016/j.isci.2020.101019_bib39 article-title: Induction of hair growth by implantation of cultured dermal papilla cells publication-title: Nature doi: 10.1038/311560a0 – volume: 10 start-page: 63 year: 2012 ident: 10.1016/j.isci.2020.101019_bib23 article-title: Paracrine TGF-beta signaling counterbalances BMPmediated repression in hair follicle stem cell activation publication-title: Cell Stem Cell doi: 10.1016/j.stem.2011.11.005 – volume: 102 start-page: 451 year: 2000 ident: 10.1016/j.isci.2020.101019_bib33 article-title: Involvement of follicular stem cells in forming not only the follicle but also the epidermis publication-title: Cell doi: 10.1016/S0092-8674(00)00050-7 – volume: 5 start-page: 610 year: 2009 ident: 10.1016/j.isci.2020.101019_bib4 article-title: SKPs derive from hair follicle precursors and exhibit properties of adult dermal stem cells publication-title: Cell Stem Cell doi: 10.1016/j.stem.2009.10.019 – volume: 5 start-page: 100 year: 2009 ident: 10.1016/j.isci.2020.101019_bib8 article-title: Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.137 – volume: 108 start-page: 11452 year: 2011 ident: 10.1016/j.isci.2020.101019_bib6 article-title: R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.1106083108 – volume: 31 start-page: 543 year: 2014 ident: 10.1016/j.isci.2020.101019_bib24 article-title: Hair follicle dermal stem cells regenerate the dermal sheath, repopulate the dermal papilla, and modulate hair type publication-title: Dev. Cell doi: 10.1016/j.devcel.2014.10.022 – volume: 34 start-page: 577 year: 2015 ident: 10.1016/j.isci.2020.101019_bib31 article-title: An integrated transcriptome atlas of embryonic hair follicle progenitors, their niche, and the developing skin publication-title: Dev. Cell doi: 10.1016/j.devcel.2015.06.023 – volume: 14 start-page: 3001 year: 2016 ident: 10.1016/j.isci.2020.101019_bib26 article-title: Signaling networks among stem cell precursors, transit-amplifying progenitors, and their niche in developing hair follicles publication-title: Cell Rep. doi: 10.1016/j.celrep.2016.02.078 – volume: 8 start-page: e78144 year: 2013 ident: 10.1016/j.isci.2020.101019_bib37 article-title: Analysis of LGR4 receptor distribution in human and mouse tissues publication-title: PLoS One doi: 10.1371/journal.pone.0078144 – volume: 110 start-page: 19679 year: 2013 ident: 10.1016/j.isci.2020.101019_bib14 article-title: Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.1309970110 – volume: 4 start-page: 155 year: 2009 ident: 10.1016/j.isci.2020.101019_bib13 article-title: A two-step mechanism for stem cell activation during hair regeneration publication-title: Cell Stem Cell doi: 10.1016/j.stem.2008.12.009 – volume: 71 start-page: 241 year: 2009 ident: 10.1016/j.isci.2020.101019_bib35 article-title: Stem cells, self-renewal, and differentiation in the intestinal epithelium publication-title: Annu. Rev. Physiol. doi: 10.1146/annurev.physiol.010908.163145 – volume: 487 start-page: 496 year: 2012 ident: 10.1016/j.isci.2020.101019_bib27 article-title: Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration publication-title: Nature doi: 10.1038/nature11218 – volume: 7 start-page: e40976 year: 2012 ident: 10.1016/j.isci.2020.101019_bib28 article-title: R-Spondin potentiates Wnt/beta-catenin signaling through orphan receptors LGR4 and LGR5 publication-title: PLoS One doi: 10.1371/journal.pone.0040976 – volume: 23 start-page: 981 year: 2012 ident: 10.1016/j.isci.2020.101019_bib10 article-title: Sox2 in the dermal papilla niche controls hair growth by finetuning BMP signaling in differentiating hair shaft progenitors publication-title: Dev. Cell doi: 10.1016/j.devcel.2012.10.013 – volume: 157 start-page: 935 year: 2014 ident: 10.1016/j.isci.2020.101019_bib15 article-title: Transit-amplifying cells orchestrate stem cell activity and tissue regeneration publication-title: Cell doi: 10.1016/j.cell.2014.02.057 – volume: 125 start-page: 4114 year: 2012 ident: 10.1016/j.isci.2020.101019_bib21 article-title: Restoration of the intrinsic properties of human dermal papilla in vitro publication-title: J. Cell Sci. doi: 10.1242/jcs.105700 – volume: 163 start-page: 609 year: 2003 ident: 10.1016/j.isci.2020.101019_bib41 article-title: Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA publication-title: J. Cell Biol. doi: 10.1083/jcb.200309042 – volume: 50 start-page: 741 year: 2012 ident: 10.1016/j.isci.2020.101019_bib20 article-title: A conditional allele of Rspo3 reveals redundant function of R-spondins during mouse limb development publication-title: Genesis doi: 10.1002/dvg.22040 – volume: 3 start-page: e331 year: 2005 ident: 10.1016/j.isci.2020.101019_bib25 article-title: Molecular dissection of mesenchymal-epithelial interactions in the hair follicle publication-title: PLoS Biol. doi: 10.1371/journal.pbio.0030331 – volume: 129 start-page: 1126 year: 2009 ident: 10.1016/j.isci.2020.101019_bib5 article-title: Human female hair follicles are a direct, nonclassical target for thyroid-stimulating hormone publication-title: J. Invest. Dermatol. doi: 10.1038/jid.2008.361 – volume: 114 start-page: 901 year: 2000 ident: 10.1016/j.isci.2020.101019_bib36 article-title: Regular articles: conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration publication-title: J. Invest. Dermatol. doi: 10.1046/j.1523-1747.2000.00951.x – volume: 28 start-page: 305 year: 2014 ident: 10.1016/j.isci.2020.101019_bib11 article-title: The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength publication-title: Genes Dev. doi: 10.1101/gad.235473.113 – volume: 303 start-page: 359 year: 2004 ident: 10.1016/j.isci.2020.101019_bib34 article-title: Defining the epithelial stem cell niche in skin publication-title: Science doi: 10.1126/science.1092436 – volume: 6 start-page: 25 year: 2010 ident: 10.1016/j.isci.2020.101019_bib2 article-title: Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro publication-title: Cell Stem Cell doi: 10.1016/j.stem.2009.11.013 – volume: 449 start-page: 1003 year: 2007 ident: 10.1016/j.isci.2020.101019_bib3 article-title: Identification of stem cells in small intestine and colon by marker gene Lgr5 publication-title: Nature doi: 10.1038/nature06196 – volume: 136 start-page: 1549 year: 2016 ident: 10.1016/j.isci.2020.101019_bib32 article-title: Activating hair follicle stem cells via R-spondin2 to stimulate hair growth publication-title: J. Invest. Dermatol. doi: 10.1016/j.jid.2016.01.041 – volume: 40 start-page: 1291 year: 2008 ident: 10.1016/j.isci.2020.101019_bib17 article-title: Lgr5 marks cycling, yet long-lived, hair follicle stem cells publication-title: Nat. Genet. doi: 10.1038/ng.239 – volume: 3 start-page: 221 year: 2016 ident: 10.1016/j.isci.2020.101019_bib18 article-title: Single-cell transcriptomics reveals that differentiation and spatial signatures shape epidermal and hair follicle heterogeneity publication-title: Cell Syst. doi: 10.1016/j.cels.2016.08.010 |
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| Title | Transcriptional Profiling of the Adult Hair Follicle Mesenchyme Reveals R-spondin as a Novel Regulator of Dermal Progenitor Function |
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