The Proangiogenic Phenotype of Natural Killer Cells in Patients with Non-Small Cell Lung Cancer

• Published in: Neoplasia (New York, N.Y.) Vol. 15; no. 2; pp. 133,IN7 - 142,IN7
• Main Authors: Bruno, Antonino, Focaccetti, Chiara, Pagani, Arianna, Imperatori, Andrea S., Spagnoletti, Marco, Rotolo, Nicola, Cantelmo, Anna Rita, Franzi, Francesca, Capella, Carlo, Ferlazzo, Guido, Mortara, Lorenzo, Albini, Adriana, Noonan, Douglas M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2013; Neoplasia Press Inc; Elsevier
• Subjects: Aged; Carcinoma, Non-Small-Cell Lung - immunology; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - pathology; Female; Humans; Immunity, Innate - genetics; Killer Cells, Natural - cytology; Killer Cells, Natural - immunology; Lung Neoplasms - immunology; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Male; Middle Aged; Neoplasm Staging; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - immunology; Oncology; Transforming Growth Factor beta1 - immunology; Transforming Growth Factor beta1 - metabolism; Tumor Microenvironment - immunology; AdC; SCC; NSCLC; NK; non-small cell lung cancer; natural killer; adenocarcinoma; squamous cell carcinoma

The tumor microenvironment can polarize innate immune cells to a proangiogenic phenotype. Decidual natural killer (dNK) cells show an angiogenic phenotype, yet the role for NK innate lymphoid cells in tumor angiogenesis remains to be defined. We investigated NK cells from patients with surgically re...