Alleviation of Hyperuricemia by Strictinin in AML12 Mouse Hepatocytes Treated with Xanthine and in Mice Treated with Potassium Oxonate

• Published in: Biology (Basel, Switzerland) Vol. 12; no. 2; p. 329
• Main Authors: Huang, Kuo-Ching, Chang, Yu-Ting, Pranata, Rosita, Cheng, Yung-Hsuan, Chen, Yu-Chi, Kuo, Ping-Chung, Huang, Yi-Hsuan, Tzen, Jason T. C., Chen, Rong-Jane
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.02.2023; MDPI
• Subjects: Acid production; Animal models; Antibodies; Blood; Enzymes; Gout; Health aspects; Hepatocytes; Hyperuricemia; Inflammasomes; Inflammation; ingredients; Intestinal microflora; intestinal microorganisms; Iron compounds; Kidneys; Laboratory animals; Liver; Metabolic disorders; mice; Microbiota; Microbiota (Symbiotic organisms); NLRP3 inflammasome; Oxidases; Pathogens; polyphenols; Potassium; Rheumatism; Risk factors; Side effects; Signal transduction; strictinin; Supplements; Tea; Uric acid; xanthine; Xanthine oxidase; Taiwan; Ann Arbor Michigan; United States > US; hyperuricemia; strictinin; NLRP3 inflammasome; xanthine; uric acid

Hyperuricemia, an abnormally high level of blood uric acid, is a major risk factor for gout. Although xanthine oxidase inhibitors were clinically used to lower blood uric acid level, the concerned side effects restricted their utilization. In this study, strictinin, an abundant polyphenol in Pu’er t...